San Diego Padres vs Philadelphia Phillies Prediction, Preview and Odds - 06/04/2026

Game Time: 1:05 pm ET, Thursday, June 4, 2026

Venue:  Citizens Bank Park, Philadelphia, PA

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Padres +153, Phillies -186; Over/Under:  8 runs

Bet365:  Moneyline odds:  Padres +155, Phillies -185; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Padres +155, Phillies -185; Over/Under:  8 runs

San Diego Padres:  32-27 (2nd place, NL West)

Philadelphia Phillies:  31-29 (2nd place, NL East)

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San Diego Padres:  3-7 last 10

Philadelphia Phillies:  6-4 last 10

The Padres are entering this series off a loss and lost their 3-game series against the Washington Nationals 2-1 in their last series. They enter this game with a 32-27 record overall and have a road record of 16-11. This is the series finale of a 3-game series with the Phillies on Thursday with the 2nd game still to be played on Wednesday. The Padres lost the series opener on Tuesday. Their offense ranks 29th in the MLB with a .656 OPS. Walker Buehler is their starting pitcher on Wednesday while Lucas Giolito is making his start in this game on Thursday. He is 2-0 with a 4.97 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 2 HR, and 4 BB with 1 SO on 5 hits through 2.2 IP against the Washington Nationals.

The Phillies are entering this series off a loss and lost their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with a 31-29 record overall and have a home record of 15-16. This is the 3rd game of a 3-game series with the Padres on Thursday with the 2nd game of this series still to be played on Wednesday. The Phillies won the 1st game of this series on Tuesday. Their offense ranks 28th in the MLB with a .675 OPS. Cristopher Sánchez is their starting pitcher on Wednesday while Zack Wheeler is making his start in this game on Thursday. He is 4-1 with a 2.27 ERA this season. His team won 6 of their last 7 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 4 homers, and 1 walk with 4 strikeouts on 5 hits through 6 innings pitched against the Los Angeles Dodgers.

The current betting odds have the Phillies listed as a favorite in this game according to Draftkings Sportsbook. The Padres have looked good in their games this season with their 32-27 record overall which has them right near the top of the NL West. They have been a better road team too with their 16-11 road record this year. Meanwhile, the Phillies have looked good in their games this season with their 31-29 record overall which has them right in the middle of the NL East. They haven't looked great in their own ballpark though with their 15-16 home record this season. The Phillies are 6-4 in their last 10 games and they have looked good lately while the Padres are 3-7 in their last 10 games and have been slipping into a slump. The Phillies already swept the Padres on the road last week and have taken the 1st game of this series too, now they are going to have the better pitching matchup to close out this series too. The Padres are going with Giolito in this one and he hasn't looked great this season. He is 2-0 with a 4.97 ERA and he has been giving up quite a few runs this year. His team has had success with him lately, winning 3 games in a row now with him as the starter, but he did give up 4 earned runs in his last start and that has been a common theme for him. The Phillies are going with Wheeler in this one and he has been a stud for the Phillies all year. He is 4-1 with a 2.27 ERA and he hasn't been giving up many runs all season. He did give up 4 earned runs in his last start, but that hasn't been a common theme for him this year, so he will be looking to bounce back with a better start and the team has also had a ton of success with him lately, winning 6 of their last 7 games with him starting. Neither offense has been great this season, but the Phillies can take advantage of this pitching matchup at home. The best way to place a bet here is on the Phillies to win this game. 

Padres Phillies Prediction:  Our MLB Pick for Thursday, June 4, 2026 (1:05 pm ET start time) is Phillies 6 Padres 2.

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San Diego Padres: 41-33 (+7.5 units) on the moneyline against NL East opponents. 221-173 (+25.7 units) on the moneyline in all games. 105-91 (+19.1 units) on the moneyline in road games. 24-12 UNDER as an underdog of +150 or more.

Philadelphia Phillies: 31-29 (-5.2 units) on the moneyline in all games. 15-16 (-7.6 units) on the moneyline in home games. 103-100 (-14.4 units) on the moneyline when playing against a team with a winning record. 15-7 UNDER against NL West opponents.

San Diego Padres:  R. Laureano (LF) Ten Day IL - Hip. L. Campusano (C) Ten Day IL - Toe. M. Waldron (SP) Fifteen Day IL - Arm. J. Cronenworth (2B) Seven Day IL - Concussion. G. Marquez (SP) Fifteen Day IL - Forearm. B. Hoeing (RP) Sixty Day IL - Elbow. N. Pivetta (SP) Sixty Day IL - Elbow. J. Musgrove (SP) Sixty Day IL - Elbow. J. Brito (RP) Sixty Day IL - Elbow.

Philadelphia Phillies:  J. Realmuto (C) Day To Day - Wrist. K. Backhus (RP) Fifteen Day IL - Elbow.

“We’ve seen him do things like that and get away with it so many times that you don’t want to take that out of him. You don’t want to take that aggressiveness out of him.” - Craig Stammen on Fernando Tatis Jr after his team’s loss against the Phillies in their game on Tuesday.

“It’s always good when you have a guy with speed who can divide the pitcher’s attention a little bit. You’re trying to hold a guy and make pitches. I think that puts more pressure on the pitcher to make pitches.” - Don Mattingly after his team’s win against the Padres in their game on Tuesday.

Fernando Tatis Jr. (R) RF

Gavin Sheets (L) 1B

Manny Machado (R) 3B

Miguel Andujar (R) DH

Jackson Merrill (L) CF

Xander Bogaerts (R) SS

Jase Bowen (R) LF

Sung-Mun Song (L) 2B

Freddy Fermin (R) C

Kyle Schwarber (L) DH

Trea Turner (R) SS

Bryce Harper (L) 1B

Brandon Marsh (L) LF

Alec Bohm (R) 3B

Bryson Stott (L) 2B

Justin Crawford (L) CF

Adolis García (R) RF

Garrett Stubbs (L) C

Batting Average:  Luis Campusano (.288)

Hits:  Fernando Tatis (60)

Home Runs:  Manny Machado (10)

RBI:  Manny Machado (30)

Stolen Bases:  Fernando Tatis (14)

Wins:  Randy Vásquez (5)

Saves:  Mason Miller (17)

ERA:  Yuki Matsui (0.57)

Batting Average:  Brandon Marsh (.332)

Hits:  Brandon Marsh (64)

Home Runs:  Kyle Schwarber (22)

RBI:  Kyle Schwarber (39)

Stolen Bases:  Trea Turner (11)

Wins:  Cristopher Sánchez (6)

Saves:  Jhoan Duran (13)

ERA:  Jhoan Duran (1.45)

Managers:

San Diego Padres: Craig Stammen (1st season)

Philadelphia Phillies: Don Mattingly (Interim)