San Diego Padres vs Philadelphia Phillies Prediction, Preview and Odds - 06/02/2026

Game Time: 6:40 pm ET, Tuesday, June 2, 2026

Venue:  Citizens Bank Park, Philadelphia, PA

Where to Watch:  MLB TV, TBS

DraftKings:  Moneyline odds:  Padres +109, Phillies -131; Over/Under:  8 runs

Bet365:  Moneyline odds:  Padres +110, Phillies -130; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Padres +110, Phillies -130; Over/Under:  8 runs

San Diego Padres:  32-26 (2nd place, NL West)

Philadelphia Phillies:  30-29 (3rd place, NL East)

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San Diego Padres:  3-7 last 10

Philadelphia Phillies:  5-5 last 10

The Padres are entering this series off a loss and lost their 3-game series against the Washington Nationals 2-1 in their last series. They enter this game with a 32-26 record overall and have a road record of 16-10. This is the series opener of a 3-game series with the Phillies on Tuesday and they have Monday off as a day of rest. Their offense ranks 29th in the MLB with a .656 OPS. Griffin Canning was their starting pitcher on Sunday while Randy Vásquez is making his start in this game on Tuesday. He is 5-3 with a 3.28 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 3 HR, and 1 BB with 2 SO on 8 hits through 5.2 IP against the Philadelphia Phillies.

The Phillies are entering this series off a loss and lost their 3-game series against the Los Angeles Dodgers 2-1 in their last series. They enter this game with a 30-29 record overall and have a home record of 14-16. This is the 1st game of a 3-game series with the Padres on Tuesday and they have Monday off as a day of rest. Their offense ranks 28th in the MLB with a .673 OPS. Rookie pitcher Andrew Painter was their starting pitcher on Sunday while Aaron Nola is making his start in this game on Tuesday. He is 3-4 with a 5.72 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 0 walks with 5 strikeouts on 3 hits through 6 innings pitched against the San Diego Padres.

The current betting odds have the Padres listed as a slight underdog in this game according to Draftkings Sportsbook. The Padres have looked good in their games this season with their 32-26 record overall which has them right near the top of the NL West. They have been a better road team too with their 16-10 road record this year. Meanwhile, the Phillies have looked good in their games this season with their 30-29 record overall which has them right in the middle of the NL East. They haven't looked great in their own ballpark though with their 14-16 home record this season. The Phillies have looked a lot better lately since their terrible start to the season, but they are still only 5-5 in their last 10 games. The Padres haven't looked any better lately, going 3-7 in their last 10, but they have looked better in road games this year and have the better pitching matchup to take advantage of in this one. The Padres are going with Vasquez in this one and he has been a solid starter for them this year. He is 5-3 with a 3.28 ERA and he hasn't been giving up many runs this year. He did give up 4 earned runs in his last start and the team has now lost 2 of their last 3 games with him starting, but that hasn't been a common theme for him and he is due to bounce back with a better start. The Phillies are going with Nola in this one and he hasn't looked great this season. He is 3-4 with a 5.72 ERA and he has been giving up quite a few runs this year. The team has been having a lot of success lately, winning 4 of their last 5 games with him starting, and he only gave up 2 earned runs in his last start too, but that hasn't really been a common theme for him this year and the Phillies haven't looked as good in their home games either. Neither team has had a great offense this season either, so look for the Padres to take advantage of this pitching matchup and bounce back. The best way to place a bet here is on the Padres to win this game. 

Padres Phillies Prediction:  Our MLB Pick for Tuesday, June 2, 2026 (6:40 pm ET start time) is Padres 5 Phillies 2.

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San Diego Padres: 41-32 (+8.6 units) on the moneyline against NL East opponents. 221-172 (+26.7 units) on the moneyline in all games. 105-90 (+20.1 units) on the moneyline in road games. 13-7 UNDER when the total is 8 to 8.5.

Philadelphia Phillies: 80-78 (-18.8 units) on the moneyline when the money line is -100 to -150. 102-100 (-15.4 units) on the moneyline when playing against a team with a winning record. 48-49 (-9.8 units) on the moneyline vs. an NL starting pitcher whose WHIP is 1.250 or better. 54-31 UNDER vs. a team with a good bullpen whose ERA is 3.45 or better.

San Diego Padres:  L. Campusano (C) Ten Day IL - Toe. M. Waldron (SP) Fifteen Day IL - Arm. J. Cronenworth (2B) Seven Day IL - Concussion. G. Marquez (SP) Fifteen Day IL - Forearm. B. Hoeing (RP) Sixty Day IL - Elbow. N. Pivetta (SP) Fifteen Day IL - Elbow. J. Musgrove (SP) Sixty Day IL - Elbow. J. Brito (RP) Sixty Day IL - Elbow.

Philadelphia Phillies:  J. Realmuto (C) Day To Day - Wrist. K. Backhus (RP) Fifteen Day IL - Elbow.

"We had Morejon kind of going. It’s just a tough spot. We can’t overuse our bullpen. They are the strength of our team and we need that strength the entire season. If you’ve got a starting pitcher on a low pitch count, you’ve got to kind of trust him.” - Craig Stammen after his team’s loss against the Nationals in their game on Sunday. 

“But I think the runs have been a little bit of a theme. We pitched really well. We haven’t really gotten on track offensively.” - Don Mattingly on his team’s offense this season. 

Fernando Tatis Jr. (R) RF

Gavin Sheets (L) DH

Manny Machado (R) 3B

Xander Bogaerts (R) SS

Jackson Merrill (L) CF

Ty France (R) 1B

Nick Castellanos (R) LF

Sung-Mun Song (L) 2B

Freddy Fermin (R) C

Kyle Schwarber (L) DH

Trea Turner (R) SS

Bryce Harper (L) 1B

Brandon Marsh (L) LF

Alec Bohm (R) 3B

Bryson Stott (L) 2B

J.T. Realmuto (R) C

Adolis García (R) RF

Justin Crawford (L) CF

Batting Average:  Luis Campusano (.288)

Hits:  Fernando Tatis (57)

Home Runs:  Manny Machado (10)

RBI:  Manny Machado (30)

Stolen Bases:  Fernando Tatis (14)

Wins:  Randy Vásquez (5)

Saves:  Mason Miller (17)

ERA:  Yuki Matsui (0.60)

Batting Average:  Brandon Marsh (.317)

Hits:  Brandon Marsh (60)

Home Runs:  Kyle Schwarber (22)

RBI:  Kyle Schwarber (39)

Stolen Bases:  Trea Turner (11)

Wins:  Cristopher Sánchez (6)

Saves:  Jhoan Duran (12)

ERA:  Cristopher Sánchez (1.47)

Managers:

San Diego Padres: Craig Stammen (1st season)

Philadelphia Phillies: Don Mattingly (Interim)