by Rod Pearson
Tuesday, Sep 22, 2026
Game Time: 10:10 pm ET, Wednesday, September 23, 2026
Venue: Dodger Stadium, Los Angeles, CA
Where to Watch: MLB TV
Opening Odds at USA Sportsbooks
DraftKings: Moneyline odds: Padres +170, Dodgers -200; Over/Under: 7.5 runs
Bet365: Moneyline odds: Padres +170, Dodgers -200; Over/Under: 7.5 runs
BetMGM: Moneyline odds: Padres +170, Dodgers -200; Over/Under: 7.5 runs
Season Record
San Diego Padres: 87-69 (2nd place, NL West)
Los Angeles Dodgers: 96-60 (1st place, NL West)
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Recent Form
San Diego Padres: 9-1 last 10
Los Angeles Dodgers: 7-3 last 10
San Diego Padres vs Los Angeles Dodgers Preview and Analysis
The Padres are entering this series off a win and completed the sweep in their 3-game series against the Miami Marlins 3-0 in their last series. They enter this game with an 87-69 record overall and have a road record of 38-40. This is the 2nd game of a 3-game series with the Dodgers on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 15th in the MLB with a .719 OPS. Michael King is their starting pitcher on Tuesday while Robbie Ray is making his start in this game on Wednesday. He is 13-8 with a 3.60 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 1 HR, and 2 BB with 6 SO on 3 hits through 6 IP against the Colorado Rockies.
The Dodgers are entering this series off a win and completed the sweep in their 3-game series against the San Francisco Giants 3-0 in their last series. They enter this game with a 96-60 record overall and have a home record of 50-28. This is the 2nd game of a 3-game series with the Padres on Wednesday with the 1st game of this series still to be played on Tuesday. Their offense ranks 2nd in the MLB with a .766 OPS. Justin Wrobleski is their starting pitcher on Tuesday while Yoshinobu Yamamoto is making his start in this game on Wednesday. He is 14-8 with a 2.51 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 2 walks with 7 strikeouts on 1 hit through 7 innings pitched against the Cincinnati Reds.
Padres vs Dodgers Prediction
The current betting odds have the Dodgers listed as a favorite in this game according to Draftkings Sportsbook. The Dodgers have looked great in their games this season with their 96-60 record overall which has them right at the top of the NL West with one of the best records in MLB. They have looked great in their own ballpark too with their 50-28 home record this season. Meanwhile, the Padres have looked good in their games this season with their 87-69 record overall which has them right near the top of the NL West. They haven't been a great road team though with their 38-40 road record this year. The Padres have been rolling lately as they are 9-1 in their last 10 games, but the Dodgers have also been hot lately. The Dodgers are 7-3 in their last 10 games and they are going to have the better pitching matchup in this one. Yamamoto is on the mound for the Dodgers in this one and he has looked great this season. He is 14-8 with a 2.51 ERA and he hasn't been giving up many runs all year. He is coming off another great start giving up no runs which has been a common theme for him all season and the team has won 2 games in a row now with him starting too. The Padres are going with Ray in this one and he has looked good this year. He is 13-8 with a 3.60 ERA, but lately he has been giving up more runs. The team has won 2 games in a row now with him starting, but he did give up 3 earned runs in his last start which has been more of an issue lately. The Dodgers also have one of the best offenses in MLB to give them the edge, so look for the Dodgers to take advantage of this pitching matchup against a team that has had a lot of trouble in road games this year. The best way to place a bet here is on the Dodgers to win this game.
Padres Dodgers Prediction: Our MLB Pick for Wednesday, September 23, 2026 (10:10 pm ET start time) is Dodgers 4 Padres 1.
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MLB Betting Trends
San Diego Padres: 276-215 (+36.8 units) on the moneyline in all games. 127-120 (+11.8 units) on the moneyline in road games. 202-151 (+34.2 units) on the moneyline against right-handed starters. 45-25 UNDER vs. an NL starting pitcher whose ERA is 3.20 or better.
Los Angeles Dodgers: 311-202 (-18.8 units) on the moneyline in all games. 166-91 (-11.4 units) on the moneyline in home games. 137-108 (-13.1 units) on the moneyline when playing against a team with a winning record. 28-18 UNDER against division opponents.
Key Injuries
San Diego Padres: L. Rengifo (LF) Sixty Day IL - Knee. G. Sheets (1B) Ten Day IL - Foot. J. Estrada (RP) Fifteen Day IL - Shoulder. M. Andujar (DH) Ten Day IL - Wrist. J. Adam (RP) Sixty Day IL - Shoulder. L. Giolito (SP) Sixty Day IL - Elbow. R. Laureano (LF) Sixty Day IL - Hip. B. Hoeing (RP) Sixty Day IL - Elbow. J. Musgrove (SP) Sixty Day IL - Elbow.
Los Angeles Dodgers: B. Snell (SP) Day To Day - Groin. E. Henriquez (RP) Fifteen Day IL - Back. S. Ohtani (DH) Fifteen Day IL - Biceps. D. Rushing (C) Ten Day IL - Elbow. E. Lauer (SP) Sixty Day IL - Elbow. R. Sasaki (SP) Fifteen Day IL - Finger. A. Pages (CF) Ten Day IL - Hand. W. Klein (RP) Sixty Day IL - Elbow. B. Graterol (RP) Sixty Day IL - Shoulder. B. Casparius (RP) Sixty Day IL - Shoulder. J. Cousins (RP) Sixty Day IL - Elbow. G. Stone (SP) Sixty Day IL - Shoulder.
Notable Quotes
“When he’s hitting in the seven hole, and he can pop two homers, that’s a big deal. That just makes our lineup as strong as we can possibly be.” - Craig Stammen after his team’s win against the Marlins in their game on Sunday.
"I feel like everyone's grinding at this point in the season." - Kyle Tucker after their win against the Giants in their game on Sunday.
Starting Lineups
San Diego Padres
Fernando Tatis Jr. (R) 2B
Dustin Harris (L) RF
Manny Machado (R) DH
Ty France (R) 1B
Jackson Merrill (L) CF
Xander Bogaerts (R) SS
Jake Cronenworth (L) 3B
Samad Taylor (R) LF
Ethan Salas (L) C
Los Angeles Dodgers
Mookie Betts (R) SS
Tommy Edman (S) CF
Teoscar Hernández (R) RF
Freddie Freeman (L) 1B
Miguel Rojas (R) 2B
Max Muncy (L) 3B
Josue De Paula (L) DH
Enrique Hernández (R) LF
Hunter Feduccia (L) C
Statistical Leaders
San Diego Padres
Batting Average: Dustin Harris (.353)
Hits: Fernando Tatis (173)
Home Runs: Manny Machado (28)
RBI: Jackson Merrill (86)
Stolen Bases: Fernando Tatis (36)
Wins: Michael King (12)
Saves: Mason Miller (37)
ERA: Mason Miller (1.21)
Los Angeles Dodgers
Batting Average: Freddie Freeman (.292)
Hits: Freddie Freeman (163)
Home Runs: Shohei Ohtani (30)
RBI: Andy Pages (80)
Stolen Bases: Andy Pages (12)
Wins: Yoshinobu Yamamoto (14)
Saves: Tanner Scott (23)
ERA: Kris Bubic (0.00)
Managers:
San Diego Padres: Craig Stammen (1st season)
Los Angeles Dodgers: Dave Roberts (11th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
