San Diego Padres vs Arizona Diamondbacks Prediction, Preview and Odds - 08/05/2026

Game Time: 9:40 pm ET, Wednesday, August 5, 2026

Venue:  Chase Field, Phoenix, AZ

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Padres -105, Diamondbacks -115; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Padres -105, Diamondbacks -115; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Padres -105, Diamondbacks -115; Over/Under:  8.5 runs

San Diego Padres:  58-55 (3rd place, NL West)

Arizona Diamondbacks:  60-53 (2nd place, NL West)

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San Diego Padres:  8-2 last 10

Arizona Diamondbacks:  6-4 last 10

The Padres are entering this series off a win and won their 4-game series against the San Francisco Giants 3-1 in their last series. They enter this game with a 58-55 record overall and have a road record of 26-30. This is the 3rd game of a 4-game series with the Diamondbacks on Wednesday with the 2nd game still to be played on Tuesday. The Padres lost the series opener on Monday. Their offense ranks 26th in the MLB with a .694 OPS. Randy Vásquez is their starting pitcher on Tuesday while Robbie Ray is making his start in this game on Wednesday. He is 10-6 with a 3.08 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 0 HR, and 1 BB with 6 SO on 4 hits through 6 IP against the San Diego Padres.

The Diamondbacks are entering this series off a loss and won their 3-game series against the Cleveland Guardians 2-1 in their last series. They enter this game with a 60-53 record overall and have a home record of 32-22. This is the 3rd game of a 4-game series with the Padres on Wednesday with the 2nd game of this series still to be played on Tuesday. The Diamondbacks won the 1st game of this series on Monday. Their offense ranks 22nd in the MLB with a .706 OPS. Eduardo Rodríguez is their starting pitcher on Tuesday while rookie pitcher Mitch Bratt is making his start in this game on Wednesday. He is 0-1 with a 5.23 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 4 walks with 2 strikeouts on 3 hits through 5 innings pitched against the Cleveland Guardians.

The current betting odds have the Padres listed as a slight underdog in this game according to Draftkings Sportsbook. The Diamondbacks have looked good in their games this season with their 60-53 record overall which has them right near the top of the NL West. They have looked good in their own ballpark too with their 32-22 home record this season. Meanwhile, the Padres have looked good in their games this season with their 58-55 record overall which has them right in the middle of the NL West. They haven't been a great road team though with their 26-30 road record this year. The Diamondbacks are 6-4 in their last 10 games and they have looked good lately, but the Padres have been rolling. The Padres are 8-2 in their last 10 games and they made a lot of moves at the trade deadline to stay competitive in this playoff race. Their offense hasn't been great this year, but neither has the Diamondbacks offense, and the Padres have a great pitching staff to lean on. They only got better with their pitching at the deadline and they are going to have the better pitching matchup in this one. The Diamondbacks are going with Bratt in this one and he hasn't looked great this season. He is 0-1 with a 5.23 ERA and he has been having a lot of trouble in his rookie year. He is coming off a good start in which he gave up 1 earned run, but that hasn't been a common theme for him and the team has lost 2 of their last 3 games with him starting. He isn't very experienced either and even with one of the worst offenses in MLB, the Padres will be able to put up runs here as they have been scoring more runs lately too. Look for the Padres to stay hot here and take advantage of this pitching matchup. The best way to place a bet here is on the Padres to win this game. 

Padres Diamondbacks Prediction:  Our MLB Pick for Wednesday, August 5, 2026 (9:40 pm ET start time) is Padres 6 Diamondbacks 5.

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San Diego Padres: 20-24 (-5.1 units) on the moneyline vs. an NL team with a slugging percentage .400 or worse on the season. 20-29 (-7.4 units) on the moneyline when playing against a team with a winning record. 19-20 (-5.2 units) on the moneyline vs. a team with a poor bullpen whose ERA is 4.20 or worse. 26-18 UNDER vs. an NL team with a slugging percentage .400 or worse on the season.

Arizona Diamondbacks: 228-209 (+8.6 units) on the moneyline in all games. 76-62 (+13.4 units) on the moneyline against division opponents. 114-110 (+17.2 units) on the moneyline when playing against a team with a winning record. 32-22 UNDER vs. an NL team with a team batting average of .255 or worse.

San Diego Padres:  G. Sheets (1B) Day To Day - Plantar Fasciitis. M. Andujar (DH) Ten Day IL - Wrist. S. Taylor (LF) Ten Day IL - Oblique. J. Adam (RP) Fifteen Day IL - Shoulder. D. Morgan (RP) Fifteen Day IL - Knee. L. Giolito (SP) Fifteen Day IL - Elbow. R. Laureano (LF) Sixty Day IL - Hip. N. Pivetta (SP) Sixty Day IL - Elbow. B. Hoeing (RP) Sixty Day IL - Elbow. J. Musgrove (SP) Sixty Day IL - Elbow.

Arizona Diamondbacks:  D. Jameson (RP) Fifteen Day IL - Hip. L. Gurriel Jr. (LF) Ten Day IL - Adductor. T. Troy (LF) Ten Day IL - Shoulder. Z. Gallen (SP) Sixty Day IL - Elbow. J. Lawlar (LF) Ten Day IL - Hamstring. M. Soroka (SP) Fifteen Day IL - Lower-Body. R. Nelson (SP) Sixty Day IL - Elbow. B. Walston (SP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. A. Puk (RP) Sixty Day IL - Elbow. C. Burnes (SP) Sixty Day IL - Elbow. J. Martinez (RP) Sixty Day IL - Elbow. A. Saalfrank (RP) Sixty Day IL - Shoulder.

“We have a tough time against his pitch mix. He’s been pitching us really well, keeping us off-balance, mixing things up. We just had a tough time with him tonight.” - Craig Stammen after his team’s loss against the Diamondbacks in their game on Monday. 

"I actually like it. I believe in the 26 guys, and I know that we're going to get a new addition in here, so it's 26 plus one. Our guys are a good baseball team, and I'm super excited about knowing what direction these guys will go in, and I don't have to pull two or three different guys from other organizations and put them on our page." - Torey Lovullo on the trade deadline. 

Fernando Tatis Jr. (R) RF

Jake Cronenworth (L) 2B

Manny Machado (R) DH

Ty France (R) 1B

Jackson Merrill (L) CF

Luis Rengifo (S) LF

Luis Campusano (R) C

Xander Bogaerts (R) SS

Sung-Mun Song (L) 3B

Corbin Carroll (L) RF

Geraldo Perdomo (S) SS

Max Kepler (L) LF

Ketel Marte (S) 2B

Nolan Arenado (R) 3B

Adrian Del Castillo (L) DH

Tim Tawa (R) 1B

James McCann (R) C

Ryan Waldschmidt (R) CF

Batting Average:  Luis Rengifo (.353)

Hits:  Fernando Tatis (122)

Home Runs:  Manny Machado (23)

RBI:  Manny Machado (65)

Stolen Bases:  Fernando Tatis (26)

Wins:  Adrian Morejon (8)

Saves:  Mason Miller (28)

ERA:  Mason Miller (0.76)

Batting Average:  James McCann (.319)

Hits:  Ketel Marte (109)

Home Runs:  Ketel Marte (19)

RBI:  Ketel Marte (62)

Stolen Bases:  Geraldo Perdomo (17)

Wins:  Eduardo Rodriguez (10)

Saves:  Paul Sewald (24)

ERA:  Gerardo Carrillo (1.13)

Managers:

San Diego Padres: Craig Stammen (1st season)

Arizona Diamondbacks: Torey Lovullo (10th season)