San Diego Padres vs Arizona Diamondbacks Prediction, Preview and Odds - 08/04/2026

Game Time: 9:40 pm ET, Tuesday, August 4, 2026

Venue:  Chase Field, Phoenix, AZ

Where to Watch:  ESPN Unlimited, MLB TV

DraftKings:  Moneyline odds:  Padres +113, Diamondbacks -136; Over/Under:  9 runs

Bet365:  Moneyline odds:  Padres +115, Diamondbacks -135; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Padres +115, Diamondbacks -135; Over/Under:  9 runs

San Diego Padres:  58-54 (3rd place, NL West)

Arizona Diamondbacks:  59-53 (2nd place, NL West)

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San Diego Padres:  8-2 last 10

Arizona Diamondbacks:  6-4 last 10

The Padres are entering this series off a win and won their 4-game series against the San Francisco Giants 3-1 in their last series. They enter this game with a 58-54 record overall and have a road record of 26-29. This is the 2nd game of a 4-game series with the Diamondbacks on Tuesday with the series opener still to be played on Monday. Their offense ranks 24th in the MLB with a .696 OPS. Michael King is their starting pitcher on Monday while Robbie Ray is making his start in this game on Tuesday. He is 10-6 with a 3.08 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 0 HR, and 1 BB with 6 SO on 4 hits through 6 IP against the San Diego Padres.

The Diamondbacks are entering this series off a loss and won their 3-game series against the Cleveland Guardians 2-1 in their last series. They enter this game with a 59-53 record overall and have a home record of 31-22. This is the 2nd game of a 4-game series with the Padres on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 22nd in the MLB with a .705 OPS. Brandon Pfaadt is their starting pitcher on Monday while Eduardo Rodríguez is making his start in this game on Tuesday. He is 10-3 with a 2.48 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 1 walk with 2 strikeouts on 5 hits through 8 innings pitched against the Pittsburgh Pirates.

The current betting odds have the Diamondbacks listed as a favorite in this game according to Draftkings Sportsbook. The Diamondbacks have looked good in their games this season with their 59-53 record overall which has them right near the top of the NL West. They have looked good in their own ballpark too with their 31-22 home record this season. Meanwhile, the Padres have looked good in their games this season with their 58-54 record overall which has them right in the middle of the NL West. They haven't been a great road team though with their 26-29 road record this year. The Padres have been rolling lately, now 8-2 in their last 10 games and just won their 4-game series against the Giants. The Diamondbacks have also been hot lately though, now 6-4 in their last 10 games, and they are going to have the better pitching matchup here. The Padres won't have one of their best options on the mound here and as hot as they have been lately, pitching has been their strength this season with one of the worst offenses in the league. The Diamondbacks are going with Rodriguez in this one and he has looked great this season. He is 10-3 with a 2.48 ERA and he has been their ace this year. He is coming off another great start giving up no runs which has been a common theme for him and the team has had a ton of success with him lately too, winning 4 games in a row now with him starting. Look for the Diamondbacks to take advantage of this better pitching matchup at home where they have looked so much better this season. The best way to place a bet here is on the Diamondbacks to win this game. 

Padres Diamondbacks Prediction:  Our MLB Pick for Tuesday, August 4, 2026 (9:40 pm ET start time) is Diamondbacks 3 Padres 1.

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San Diego Padres: 74-62 (-7.1 units) on the moneyline vs. NL teams allowing 4.5 or more runs/game on the season. 27-38 (-6.2 units) on the moneyline vs. an NL starting pitcher whose ERA is 3.20 or better. 20-28 (-6.3 units) on the moneyline when playing against a team with a winning record. 25-18 UNDER vs. an NL team with a slugging percentage .400 or worse on the season.

Arizona Diamondbacks: 227-209 (+7.6 units) on the moneyline in all games. 75-62 (+12.4 units) on the moneyline against division opponents. 113-110 (+16.2 units) on the moneyline when playing against a team with a winning record. 31-22 UNDER vs. an NL team with a team batting average of .255 or worse.

San Diego Padres:  M. Andujar (DH) Ten Day IL - Wrist. S. Taylor (LF) Ten Day IL - Oblique. J. Adam (RP) Fifteen Day IL - Shoulder. D. Morgan (RP) Fifteen Day IL - Knee. L. Giolito (SP) Fifteen Day IL - Elbow. R. Laureano (LF) Sixty Day IL - Hip. N. Pivetta (SP) Sixty Day IL - Elbow. B. Hoeing (RP) Sixty Day IL - Elbow. J. Musgrove (SP) Sixty Day IL - Elbow.

Arizona Diamondbacks:  D. Jameson (RP) Fifteen Day IL - Hip. L. Gurriel Jr. (LF) Ten Day IL - Adductor. T. Troy (LF) Ten Day IL - Shoulder. Z. Gallen (SP) Fifteen Day IL - Elbow. J. Lawlar (LF) Ten Day IL - Hamstring. M. Soroka (SP) Fifteen Day IL - Lower-Body. R. Nelson (SP) Sixty Day IL - Elbow. B. Walston (SP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. A. Puk (RP) Sixty Day IL - Elbow. C. Burnes (SP) Sixty Day IL - Elbow. J. Martinez (RP) Sixty Day IL - Elbow. A. Saalfrank (RP) Sixty Day IL - Shoulder.

“The pitching staff has continued to pick each other up throughout the whole course of the week. And the hitters have done their job, too, being able to score early and give us a little bit of a cushion to use guys how we would like to use them. It’s been complete baseball.” - Craig Stammen after his team’s win against the Giants in their game on Sunday. 

“At one point, I just signaled over to him and said, ‘Come on, let's talk about this, you and I.’ And I heard him saying to the umpire, ‘I just want to go talk to Torey,’ so I appreciated that. Like I said, through some hard lessons and suspensions and fines, I've learned the hard way to de-escalate instead of amplify it, and in that case, I felt like that was my job. Vogt and I got together and talked about it. And he saw it the same way I did. He had no problem with what Tawa did based on the conversation there at home plate.” - Torey Lovullo after his team’s loss against the Guardians in their game on Sunday. 

Luis Rengifo (S) LF

Jake Cronenworth (L) 2B

Manny Machado (R) DH

Ty France (R) 1B

Jackson Merrill (L) CF

Luis Campusano (R) C

Gavin Sheets (L) RF

Xander Bogaerts (R) SS

Sung-Mun Song (L) 3B

Corbin Carroll (L) RF

Geraldo Perdomo (S) SS

Gabriel Moreno (R) C

Ketel Marte (S) DH

Max Kepler (L) LF

Nolan Arenado (R) 3B

Tim Tawa (R) CF

Ildemaro Vargas (S) 2B

Tyler Locklear (R) 1B

Batting Average:  Luis Rengifo (.362)

Hits:  Fernando Tatis (122)

Home Runs:  Manny Machado (23)

RBI:  Manny Machado (65)

Stolen Bases:  Fernando Tatis (26)

Wins:  Adrian Morejon (8)

Saves:  Mason Miller (28)

ERA:  Mason Miller (0.76)

Batting Average:  Jordan Lawlar (.316)

Hits:  Ketel Marte (109)

Home Runs:  Ketel Marte (19)

RBI:  Ketel Marte (62)

Stolen Bases:  Geraldo Perdomo (17)

Wins:  Eduardo Rodriguez (10)

Saves:  Paul Sewald (24)

ERA:  Gerardo Carrillo (1.13)

Managers:

San Diego Padres: Craig Stammen (1st season)

Arizona Diamondbacks: Torey Lovullo (10th season)