by Rod Pearson
Wednesday, Sep 17, 2025
Game Time: 3:30 pm ET, Saturday, September 20, 2025
Venue: Notre Dame Stadium, Notre Dame, IN
Where to Watch: NBC, Peacock
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Purdue +24.5, Notre Dame -24.5; Over/Under: 54.5 points
Bet365: Point Spread: Purdue +24.5, Notre Dame -24.5; Over/Under: 54.5 points
BetMGM: Point Spread: Purdue +24.5, Notre Dame -24.5; Over/Under: 54.5 points
Season Record
Purdue Boilermakers: 2-1 (0-1) (15th place, Big Ten)
Notre Dame Fighting Irish: 0-2 (0-0) (FBS Independent)
Do not miss out on our expert handicapper analysis! Big Al McMordie is on a HOT STREAK in college football on an 11-4 CFB RUN for +$6,600 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.
Recent Form
Purdue Boilermakers: lost their last game at home against the USC Trojans 33-17.
Notre Dame Fighting Irish: lost their last game at home against the Texas A&M Aggies 41-40.
Purdue Boilermakers vs Notre Dame Fighting Irish Preview and Analysis
Purdue is entering this game with a 2-1 record overall and they have a 0-1 record in their conference games too. They are 2-1 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against USC 33-17. Ryan Browne was the starting QB and he completed 24/39 passes for 305 passing yards, 1 touchdown, and 3 interceptions. Devin Mockobee led the team in rushing yards with 45. Michael Jackson III led the receivers with 70 receiving yards on 7 receptions. Myles Slusher led the defense in that game with 9 solo tackles and 3 assisted tackles while Demeco Kennedy led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Notre Dame is entering this game with a 0-2 record overall and they have a 0-0 record in their conference games too. They are 0-1 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Texas A&M 41-40. CJ Carr was the starting QB and he completed 20/32 passes for 293 passing yards, 1 touchdown, and 1 interception. Jeremiyah Love led the team in rushing yards with 94 and 1 TD. Eli Raridon led the receivers with 85 receiving yards on 4 receptions. Tae Johnson led the defense in that game with 6 solo tackles and 0 assisted tackles while no one on the defense recorded a sack for them. Leonard Moore came away with the only interception for them in that one.
Purdue vs Notre Dame Prediction
The current betting odds have Notre Dame listed as a 24.5 point favorite in this game according to Draftkings Sportsbook. Notre Dame hasn't looked good in their games this season with their 0-2 record overall which has put them behind the ball in the playoff race. They will have to run the table if they want to make a playoff appearance this year, but their 2 losses were against 2 teams that look to be really good this season. Notre Dame is in much need of a weaker opponent to get their first win of the season and that is exactly what they will be getting here. Purdue has looked good in their games this season with their 2-1 record overall, but they have been one of the worst teams in the Big Ten the last few seasons and that isn't going to change this year. They have a new head coach who is going to need some time to turn things around. They got their first test of the season last week with a 33-17 loss to USC, but all 3 of their games have also been at home this season so this is going to be their first road game and it is also their toughest opponent so far. Notre Dame's defense hasn't looked great in their 2 games, but they will look a lot better against this Purdue offense, and Notre Dame's offense has also looked really good. This is a great situation for Notre Dame to bounce back and pick up their first win of the year. The best way to place a bet here is on Notre Dame to cover the spread in this game.
Purdue Notre Dame Prediction: Our NCAAF Pick for Saturday, September 20, 2025 (3:30 pm ET start time) is Notre Dame 42 Purdue 13.
Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Purdue Boilermakers Notre Dame Fighting Irish prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.
NCAAF Betting Trends
Purdue Boilermakers: 9-18 ATS in all lined games. 6-13 ATS as an underdog. 5-9 ATS off a loss against a conference rival. 1-5 ATS after a game with a turnover margin of -2 or worse. 9-5 OVER off a loss against a conference rival. 6-1 OVER off a home loss by 14 or more points.
Notre Dame Fighting Irish: 20-8 ATS in all lined games. 18-7 ATS as a favorite. 20-8 ATS in non-conference games. 9-2 ATS vs. good teams - outscoring opponents by 10+ PPG on the season. 20-11 OVER in all lined games. 18-9 OVER as a favorite.
Key Injuries
Purdue Boilermakers: I. Needam (CB) Questionable - Undisclosed. J. Grimmett (TE) Questionable - Foot. D. Morrissette (WR) Questionable - Undisclosed. C. Magwood (WR) Questionable - Undisclosed. C. Wakley (CB) Questionable - Undisclosed. J. Hall (WR) Out - Leg.
Notre Dame Fighting Irish: D. Smith (CB) Questionable - Undisclosed. N. Burnette (K) Questionable - Undisclosed. C. Flanagan (TE) Questionable - Achilles. C. Jagusah (OG) Questionable - Undisclosed. P. Jones (OG) Questionable - Ankle. J. Fisher (TE) Questionable - Knee. D. Houstan (OG) Questionable - Knee. K. Young (RB) Out - Knee. K. Bauman (TE) Out - Knee. B. Logan (S) Out - Shoulder. D. Devezin (RB) Out - Shoulder.
Notable Quotes
“A good team and you've got to step into the ring and into the arena and be ready for them to swing. And we kept swinging, so we'll learn from today in a lot of different ways.” - Barry Odom after his team’s loss against USC in their last game.
“You’ve got to go to work and practice and get better. We’re 0-2. So what do you control? You control getting better and getting ready for the next one. I can’t sit here and dwell on being 0-2 as much as I need to dwell on how do we find ways to improve.” - Marcus Freeman after his team’s loss against Texas A&M in their last game.
Starting Lineups
Purdue Boilermakers
WR Tuggle, Nitro
WR Branch, Arhmad
WR Jackson III, Michael
TE Walker, Rico
QB Browne, Ryan
RB Mockobee, Devin
Notre Dame Fighting Irish
WR Fields, Malachi
WR Faison, Jordan
WR Greathouse, Jaden
TE Raridon, Eli
QB Carr, CJ
RB Love, Jeremiyah
Statistical Leaders
Purdue Boilermakers
Passing: R. Browne (786)
Rushing: D. Mockobee (230)
Receiving: A. Branch (167)
Touchdowns: D. Mockobee (3)
Notre Dame Fighting Irish
Passing: C. Carr (514)
Rushing: J. Love (127)
Receiving: E. Raridon (182)
Touchdowns: J. Love (2)
Coaches:
Purdue Boilermakers: Barry Odom (1st season)
Notre Dame Fighting Irish: Marcus Freeman (5th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
