Portland Trail Blazers vs San Antonio Spurs Prediction, Preview and Odds - 04/21/2026

Game Time: 8:00 pm ET, Tuesday, April 21, 2026

Venue:  Frost Bank Center, San Antonio, TX

Where to Watch:  NBC, Peacock

DraftKings:  Point Spread:  Trail Blazers +11.5, Spurs -11.5; Over/Under:  219.5 points

Bet365:  Point Spread:  Trail Blazers +11.5, Spurs -11.5; Over/Under:  220.5 points

BetMGM:  Point Spread:  Trail Blazers +11.5, Spurs -11.5; Over/Under:  220.5 points

Portland Trail Blazers:  42-40 (4th place, Northwest Division)

San Antonio Spurs:  62-20 (1st place, Southwest Division)

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Portland Trail Blazers:  6-4 last 10

San Antonio Spurs:  8-2 last 10

The Trail Blazers are entering the playoffs with a 42-40 record overall this season and they were 18-23 in their road games where they will be in this game. They are entering this game off a loss against the San Antonio Spurs. Deni Avdija led the team in points in that game with 30 while Scoot Henderson was next on the team with 18 points. Jrue Holiday led the team in assists in that game with 11 while Deni Avdija led the team in rebounds with 10. They were 42.9% from the field, 26.3% from 3-point range, and 83.3% from the free throw line with their shots in that game. Their offense is averaging 115.5 PPG and their defense is allowing their opponents to average 115.8 PPG against them. The Trail Blazers have an ATS record of 45-39 this season and their O/U record is 43-41.

The Spurs are entering the playoffs with a 62-20 record overall this season and they were 32-8 in their home games where they will be in this game. They are entering this game off a win against the Portland Trail Blazers. Victor Wembanyama led the team in points in that game with 35 while Stephon Castle and De'Aaron Fox each were next on the team with 17 points. De'Aaron Fox led the team in assists in that game with 8 while Stephon Castle and Keldon Johnson each led the team in rebounds with 7. They were 47.6% from the field, 45.5% from 3-point range, and 84.2% from the free throw line with their shots in that game. Their offense is averaging 119.8 PPG and their defense is allowing their opponents to average 111.5 PPG against them. The Spurs have an ATS record of 47-35-2 this season and their O/U record is 37-47.

The current betting odds have the Spurs listed as an 11.5 point favorite in this game according to Draftkings Sportsbook. The Spurs have looked great in their games this season with their 62-20 record overall which had them right near the top of the West with one of the best records in the entire NBA. They have looked great on their home court too with their 32-8 home record this season. Meanwhile, the Trail Blazers have looked good in their games this season with their 42-40 record overall which had them right in the middle of the West. They haven't been a great road team though with their 18-23 road record this year. This is game 2 of a 7-game series between the 2 seeded Spurs and the 7 seeded Trail Blazers in the West for the 1st round of the NBA playoffs. The Spurs are entering this game with a 1-0 series lead after winning game 1 by a score of 111-98. The Trail Blazers are 6-4 in their last 10 games and they really had to earn their spot in the playoffs. They have looked great over the last 2 weeks and even went on the road in the play-in tournament to beat the Suns, but they have also been beating up on a lot of the bad teams in the NBA lately and the Spurs reminded them of their place in the league. The Trail Blazers had a great season as they really came out of nowhere to make the playoffs, but this isn't a true playoff team and they aren't going to last long in this series. The Spurs have been one of the best teams in the NBA all season and they have been rolling lately too. They are 8-2 in their last 10 games with one of the best defenses in the NBA too and they didn't even give up 100 points in game 1. The Trail Blazers are just happy to be here and even though the Spurs haven't been in the playoffs in years, they have looked like a true contender all season, so look for them to roll over the Trail Blazers again on their home court. The best way to place a bet here is on the Spurs to cover the spread in this game. 

Trail Blazers Spurs Prediction:  Our NBA Pick for Tuesday, April 21, 2026 (8:00 pm ET start time) is Spurs 114 Trail Blazers 94.

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Portland Trail Blazers: 17-10 ATS revenging a same season loss vs opponent. 17-8 ATS in a road game where the total is 210 to 219.5. 16-9 UNDER as a road underdog. 13-4 UNDER versus good rebounding teams - outrebounding opponents by 3+ per game. 6-3 UNDER versus poor pressure defensive teams - forcing 13 turnovers/game or less.

San Antonio Spurs: 7-11 ATS as a home favorite of 6.5 to 12 points. 3-6 ATS at home against Northwest division opponents. 8-4 UNDER after allowing 100 points or less. 13-5 UNDER when playing against a marginal winning team (Win Pct. 51% to 60%). 9-5 UNDER as a home favorite of 6.5 to 12 points.

Portland Trail Blazers:  D. Lillard (PG) Out For Season - Achilles.

San Antonio Spurs:  J. McLaughlin (PG) Day To Day - Ankle. D. Jones Garcia (SF) Out For Season - Ankle.

“The Spurs put you in tough positions. Against them, you've got to shoot the ball well from 3s. We didn't. We've got to shoot the ball better.” - Tiago Splitter after his team’s loss against the Spurs in the 1st game of this series on Sunday. 

“It is obviously different, but we’ve been really good in the regular season. So, we have no reason to act differently or do anything different.” - Victor Wembanyama after their win against the Trail Blazers in game 1 of this series on Sunday. 

PG Scoot Henderson

SG Jrue Holiday

SF Toumani Camara

PF Deni Avdija

C Donovan Clingan

PG De'Aaron Fox

SG Stephon Castle

SF Devin Vassell

PF Julian Champagnie

C Victor Wembanyama

PPG: Deni Avdija (24.2)

APG: Deni Avdija (6.7)

Reb/G: Donovan Clingan (11.6)

PPG: Victor Wembanyama (25)

APG: Stephon Castle (7.4)

Reb/G: Victor Wembanyama (11.5)

Coaches:

Portland Trail Blazers: Tiago Splitter (1st season)

San Antonio Spurs: Mitch Johnson (2nd season)