Pittsburgh Pirates vs Milwaukee Brewers Prediction, Preview and Odds - 08/04/2026

Game Time: 7:40 pm ET, Tuesday, August 4, 2026

Venue:  American Family Field, Milwaukee, WI 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Pirates +136, Brewers -164; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Pirates +135, Brewers -165; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Pirates +140, Brewers -165; Over/Under:  7.5 runs

Pittsburgh Pirates:  56-57 (3rd place, NL Central)

Milwaukee Brewers:  69-42 (1st place, NL Central)

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Pittsburgh Pirates:  3-7 last 10

Milwaukee Brewers:  6-4 last 10

The Pirates are entering this series off a loss and lost their 4-game series against the Cincinnati Reds 3-1 in their last series. They enter this game with a 56-57 record overall and have a road record of 27-29. This is the 2nd game of a 4-game series with the Brewers on Tuesday with the series opener still to be played on Monday. Their offense ranks 3rd in the MLB with a .751 OPS. Bubba Chandler is their starting pitcher on Monday while Jared Jones is making his start in this game on Tuesday. He is 2-2 with a 3.81 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 1 HR, and 2 BB with 5 SO on 4 hits through 6 IP against the Arizona Diamondbacks.

The Brewers are entering this series off a loss and won their 3-game series against the Los Angeles Angels 2-1 in their last series. They enter this game with a 69-42 record overall and have a home record of 36-20. This is the 2nd game of a 4-game series with the Pirates on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 7th in the MLB with a .736 OPS. Brandon Sproat is their starting pitcher on Monday while Logan Henderson is making his start in this game on Tuesday. He is 5-1 with a 2.66 ERA this season. His team won their last 7 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 2 walks with 7 strikeouts on 2 hits through 5.2 innings pitched against the San Francisco Giants.

The current betting odds have the Brewers listed as a favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 69-42 record overall which has them right at the top of the NL Central with one of the best records in MLB. They have looked great in their own ballpark too with their 36-20 home record this season. Meanwhile, the Pirates haven't looked great in their games this season with their 56-57 record overall which has them right in the middle of the NL Central. They haven't been a great road team either with their 27-29 road record this year. The Pirates have been hovering right around .500 all season and they have been firmly in the playoff race, but lately they haven't looked that great and are 3-7 in their last 10 games. The Brewers have steadily been one of the best teams in the league all season though and lately they have looked good too, now 6-4 in their last 10 games. The Pirates are going with Jones in this one and he hasn't looked great this season. He is 2-2 with a 3.81 ERA and he hasn't been giving up a ton of runs, but the team hasn't had a lot of success with him lately. They have lost 2 games in a row now with him starting and he did give up 3 earned runs in his last start which has been a common theme for him all year. The Brewers are going with Henderson in this one and he has looked good this year. He is 5-1 with a 2.66 ERA and he hasn't been giving up many runs at all. He is coming off another great start giving up no runs which has been a common theme for him and the team has had a ton of success with him lately too, winning 7 games in a row now with him starting. The Brewers definitely have the better pitching matchup here along with the better bullpen too and even though the Pirates do have one of the best offenses in the league, the Brewers also have a really good offense too. The best way to place a bet here is on the Brewers to win this game. 

Pirates Brewers Prediction:  Our MLB Pick for Tuesday, August 4, 2026 (7:40 pm ET start time) is Brewers 4 Pirates 2.

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Pittsburgh Pirates: 204-233 (-21.7 units) on the moneyline in all games. 91-126 (-18.2 units) on the moneyline in road games. 64-77 (-13.1 units) on the moneyline against division opponents. 31-16 OVER when the total is 8 to 8.5.

Milwaukee Brewers: 263-185 (+49.5 units) on the moneyline in all games. 138-87 (+21.3 units) on the moneyline in home games. 166-99 (+22.7 units) on the moneyline as a favorite of -110 or higher. 33-17 OVER as a home favorite of -150 to -200.

Pittsburgh Pirates:  R. O'Hearn (RF) Ten Day IL - Quad. O. Cruz (CF) Sixty Day IL - Hand. K. Griffin (SS) Sixty Day IL - Finger. E. Sisk (RP) Fifteen Day IL - Elbow. C. Devenski (RP) Sixty Day IL - Illness.

Milwaukee Brewers:  S. Frelick (RF) Ten Day IL - Shoulder. R. Zastryzny (RP) Sixty Day IL - Shoulder. B. Woodruff (SP) Sixty Day IL - Shoulder. K. Harrison (SP) Fifteen Day IL - Forearm. J. Kuhnel (RP) Fifteen Day IL - Shoulder. Q. Priester (SP) Sixty Day IL - Wrist. B. Fitzpatrick (RP) Sixty Day IL - Elbow. A. Zerpa (RP) Sixty Day IL - Forearm.

“Good stuff. First time coming out, I know Stephenson got him there, but I thought the stuff looked good, and we're excited to have him in the back of the ‘pen.” - Don Kelly on Camilo Doval after his team’s loss against the Reds in their game on Sunday. 

“I’m looking at the guys that we have. I think we have a shot with this team.” - Jacob Misiorowski on the team being a World Series contender.

Jake Mangum (S) LF

Brandon Lowe (L) 2B

Bryan Reynolds (S) DH

Esmerlyn Valdez (R) RF

Spencer Horwitz (L) 1B

Nick Gonzales (R) 3B

Endy Rodríguez (S) C

Jacob Gonzalez (L) SS

Jhostynxon Garcia (R) CF

Brice Turang (L) 2B

Jackson Chourio (R) LF

Garrett Mitchell (L) CF

William Contreras (R) C

Jake Bauers (L) DH

Andrew Vaughn (R) 1B

Luis Lara (S) RF

Cooper Pratt (R) SS

David Hamilton (L) 3B

Batting Average:  Nick Gonzales (.312)

Hits:  Nick Gonzales (127)

Home Runs:  Brandon Lowe (23)

RBI:  Brandon Lowe (71)

Stolen Bases:  Oneil Cruz (21)

Wins:  Braxton Ashcraft (11)

Saves:  Gregory Soto (14)

ERA:  Khristian Curtis (0.00)

Batting Average:  Tyler Black (.333)

Hits:  Brice Turang (111)

Home Runs:  Jake Bauers (20)

RBI:  Brice Turang (69)

Stolen Bases:  David Hamilton (20)

Wins:  Aaron Ashby (12)

Saves:  Trevor Megill (18)

ERA:  Easton McGee (0.00)

Managers:

Pittsburgh Pirates: Don Kelly (2nd season)

Milwaukee Brewers: Pat Murphy (3rd season)