Philadelphia Phillies vs Cincinnati Reds Prediction, Preview and Odds - 08/13/2025

Game Time: 5:10 pm ET, Wednesday, August 13, 2025

Venue:  Great American Ball Park, Cincinnati, OH

Where to Watch:  NBCS-P, FDSOH

DraftKings:  Moneyline odds:  Phillies -144, Reds +118; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Phillies -140, Reds +120; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Phillies -140, Reds +120; Over/Under:  8.5 runs

Philadelphia Phillies:  69-49 (1st place, NL East)

Cincinnati Reds:  62-58 (3rd place, NL Central)

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Philadelphia Phillies:  8-2 last 10

Cincinnati Reds:  5-5 last 10

The Phillies are entering this series off a win and completed the sweep in their 3-game series against the Texas Rangers 3-0 in their last series. They enter this game with a 69-49 record overall and have a road record of 32-28. This is the series finale of a 3-game series with the Reds on Wednesday with the 2nd game still to be played on Tuesday. The Phillies won the series opener on Monday. Their offense ranks 8th in the MLB with a .744 OPS. Ranger Suárez is their starting pitcher on Tuesday while Cristopher Sánchez is making his start in this game on Wednesday. He is 11-3 with a 2.36 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 ER, 0 HR, and 1 BB with 6 SO on 6 hits through 6 IP against the Texas Rangers.

The Reds are entering this series off a win and split their 4-game series against the Pittsburgh Pirates 2-2 in their last series. They enter this game with a 62-58 record overall and have a home record of 33-27. This is the 3rd game of a 3-game series with the Phillies on Wednesday with the 2nd game of this series still to be played on Tuesday. The Reds lost the 1st game of this series on Monday. Their offense ranks 20th in the MLB with a .708 OPS. Brady Singer is their starting pitcher on Tuesday while Hunter Greene is making his start in this game on Wednesday. He is 4-3 with a 2.72 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 3 walks with 7 strikeouts on 5 hits through 5 innings pitched against the Milwaukee Brewers.

The current betting odds have the Phillies listed as a favorite in this game according to Draftkings Sportsbook. The Phillies have looked great in their games this season with their 69-49 record overall which has them right at the top of the NL East with one of the best records in the entire MLB. They have also been a good road team this season with their 32-28 road record. Meanwhile, the Reds have looked good in their games this season with their 62-58 record overall which has them right in the middle of the NL Central. They have also looked better in their own ballpark this year with their 33-27 home record. The Reds already lost the 1st game of this series on Monday and they haven't looked great lately either. The Reds are only 5-5 in their last 10 games while the Phillies are 8-2 in their last 10 and seem to be surging at the right time. Sanchez is on the mound for the Phillies in this one and he has looked great this season. He is 11-3 with a 2.36 ERA and he has been one of their best starters all year. He is coming off another great start in which he gave up 1 earned run and the team has won 2 games in a row now with him starting too. The Reds are going with Greene in this one and he has also looked good this season. He is 4-3 with a 2.72 ERA and hasn't been giving up many runs in his starts, but he is also coming back from an injury. He only gave up 2 earned runs in his last start, but the team still lost 2 of their last 3 games with him starting and there is no guarantee he is going to pitch that way in his 1st start back from an injury. The Phillies have also been rolling lately so all signs point to them winning with Sanchez on the mound here. The best way to place a bet here is on the Phillies to win this game.

Phillies Reds Prediction:  Our MLB Pick for Wednesday, August 13, 2025 (5:10 pm ET start time) is Phillies 3 Reds 1.

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Philadelphia Phillies: 264-196 (+8.5 units) on the moneyline in all games. 212-127 (+16.2 units) on the moneyline as a favorite of -110 or higher. 183-127 (+17.4 units) on the moneyline against right-handed starters. 50-32 UNDER against NL Central opponents.

Cincinnati Reds: 42-49 (-6.8 units) on the moneyline against NL East opponents. 109-112 (-14.6 units) on the moneyline in home games. 56-71 (-14.4 units) on the moneyline against left-handed starters. 56-28 UNDER when playing against a good team (Win Pct. 54% to 62%).

Philadelphia Phillies:  D. Robert (RP) Fifteen Day IL - Blister. A. Bohm (3B) Ten Day IL - Ribcage. A. Nola (SP) Sixty Day IL - Ankle.

Cincinnati Reds:  N. Lodolo (SP) Fifteen Day IL - Finger. W. Miley (SP) Sixty Day IL - Flexor. I. Gibaut (RP) Fifteen Day IL - Shoulder. H. Greene (SP) Fifteen Day IL - Groin. R. Lowder (SP) Sixty Day IL - Forearm. C. Spiers (RP) Sixty Day IL - Shoulder. T. Callihan (LF) Sixty Day IL - Forearm. B. Williamson (SP) Sixty Day IL - Elbow. J. Aguiar (SP) Sixty Day IL - Elbow.

“Really valuable. You know one thing, he's going to compete -- and he's not afraid of anything. He's a really valuable person to have on this club.” - Rob Thomson on Taijuan Walker after his team’s win against the Reds in their game on Monday.

“We know our schedule is hard. We’re not making any excuses. We’ve just got to play better at the end of the day. There’s some certain facets -- like me backing up [the plate], me making pitches. Defense made some plays behind me. We just had a few things go our way, but we needed a few more." - Andrew Abbott after their loss against the Phillies in their game on Monday.

Trea Turner (R) SS

Kyle Schwarber (L) DH

Bryce Harper (L) 1B

J.T. Realmuto (R) C

Nick Castellanos (R) RF

Harrison Bader (R) CF

Otto Kemp (R) 3B

Edmundo Sosa (R) 2B

Weston Wilson (R) LF

TJ Friedl (L) CF

Spencer Steer (R) 1B

Elly De La Cruz (S) SS

Miguel Andujar (R) DH

Gavin Lux (L) LF

Noelvi Marte (R) RF

Tyler Stephenson (R) C

Matt McLain (R) 2B

Ke'Bryan Hayes (R) 3B

Batting Average:  Trea Turner (.282)

Hits:  Trea Turner (135)

Home Runs:  Kyle Schwarber (42)

RBI:  Kyle Schwarber (97)

Stolen Bases:  Trea Turner (26)

Wins:  Cristopher Sánchez (11)

Saves:  Jordan Romano (8)

ERA:  Jhoan Duran (0.00)

Batting Average:  Austin Wynns (.400)

Hits:  Elly De La Cruz (127)

Home Runs:  Elly De La Cruz (19)

RBI:  Elly De La Cruz (74)

Stolen Bases:  Elly De La Cruz (31)

Wins:  Nick Martinez (10)

Saves:  Emilio Pagán (25)

ERA:  Andrew Abbott (2.41)

Managers:

Philadelphia Phillies: Rob Thomson (4th season)

Cincinnati Reds: Terry Francona (1st season)