Philadelphia Phillies vs Arizona Diamondbacks Prediction, Preview and Odds - 09/01/2026

Game Time: 9:40 pm ET, Tuesday, September 1, 2026

Venue:  Chase Field, Phoenix, AZ

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Phillies -136, Diamondbacks +113; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Phillies -135, Diamondbacks +115; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Phillies -140, Diamondbacks +115; Over/Under:  7.5 runs

Philadelphia Phillies:  77-60 (2nd place, NL East)

Arizona Diamondbacks:  73-65 (2nd place, NL West)

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Philadelphia Phillies:  8-2 last 10

Arizona Diamondbacks:  6-4 last 10

The Phillies are entering this series off a win and completed the sweep in their 3-game series against the Los Angeles Angels 3-0 in their last series. They enter this game with a 77-60 record overall and have a road record of 39-30. This is the 2nd game of a 3-game series with the Diamondbacks on Tuesday with the series opener still to be played on Monday. Their offense ranks 17th in the MLB with a .716 OPS. Aaron Nola is their starting pitcher on Monday while Jesús Luzardo is making his start in this game on Tuesday. He is 12-5 with a 3.09 ERA this season. His team won their last 5 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 0 ER, 0 HR, and 3 BB with 9 SO on 1 hit through 7 IP against the Seattle Mariners.

The Diamondbacks are entering this series off a loss and split their 4-game series against the San Francisco Giants 2-2 in their last series. They enter this game with a 73-65 record overall and have a home record of 40-29. This is the 2nd game of a 3-game series with the Phillies on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 19th in the MLB with a .714 OPS. Brandon Pfaadt is their starting pitcher on Monday while Eduardo Rodríguez is making his start in this game on Tuesday. He is 14-4 with a 2.50 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 3 walks with 9 strikeouts on 2 hits through 7 innings pitched against the Chicago Cubs.

The current betting odds have the Diamondbacks listed as an underdog in this game according to Draftkings Sportsbook. The Diamondbacks have looked good in their games this season with their 73-65 record overall which has them right near the top of the NL West. They have looked great in their own ballpark too with their 40-29 home record this season. Meanwhile, the Phillies have looked really good in their games this season with their 77-60 record overall which has them right near the top of the NL East. They have been a good road team too with their 39-30 road record this year. The Phillies have been rolling lately as they are 8-2 in their last 10 games, but the Diamondbacks have also been really hot themselves. The Diamondbacks are 6-4 in their last 10 games and they need this series a lot more since they just passed the Padres for the last Wild Card spot in the NL. The Phillies are going with Luzardo in this one and he has looked great this season. He is 12-5 with a 3.09 ERA and he hasn't been giving up many runs lately. He is coming off another great start giving up no runs which has been a common theme for him and the team has been having a ton of success with him too, winning 5 games in a row now with him starting. The Diamondbacks are going with Rodriguez in this one though and he has been a stud for them all season. He is 14-4 with a 2.50 ERA and he has been their best starter. He is coming off another great start giving up no runs which has been a common theme for him all year and the team has been having a lot of success with him too, winning 4 games in a row now with him starting. Both offenses have been really similar this season too, so this game is going to come down to pitching and Rodriguez gives the Diamondbacks the edge here at home, playing with some desperation as they enter this final stretch of the regular season. The best way to place a bet here is on the Diamondbacks to win this game. 

Phillies Diamondbacks Prediction:  Our MLB Pick for Tuesday, September 1, 2026 (9:40 pm ET start time) is Diamondbacks 2 Phillies 1.

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Philadelphia Phillies: 122-113 (-10.9 units) on the moneyline in road games. 99-92 (-17.2 units) on the moneyline when the money line is -100 to -150. 83-74 (-13.1 units) on the moneyline against left-handed starters. 33-21 UNDER when the money line is -100 to -150.

Arizona Diamondbacks: 241-221 (+9.2 units) on the moneyline in all games. 98-112 (+15.9 units) on the moneyline as an underdog of +100 or higher. 73-65 (+8 units) on the moneyline against left-handed starters. 13-4 UNDER as a home underdog of +100 or higher.

Philadelphia Phillies:  F. Reyes (LF) Sixty Day IL - Wrist. C. Kilian (RP) Fifteen Day IL - Oblique. T. Banks (RP) Sixty Day IL - Forearm. R. Marchan (C) Ten Day IL - Knee. B. Keller (RP) Sixty Day IL - Elbow. J. Rojas (CF) Sixty Day IL - Elbow. A. Garcia (RF) Sixty Day IL - Lat.

Arizona Diamondbacks:  M. Soroka (SP) Fifteen Day IL - Arm. K. Marte (2B) Ten Day IL - Knee. R. Thompson (RP) Fifteen Day IL - Back. Z. Gallen (SP) Sixty Day IL - Elbow. L. Gurriel Jr. (LF) Ten Day IL - Adductor. T. Troy (LF) Ten Day IL - Shoulder. R. Nelson (SP) Sixty Day IL - Elbow. B. Walston (SP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. C. Burnes (SP) Sixty Day IL - Elbow. A. Puk (RP) Sixty Day IL - Elbow. A. Saalfrank (RP) Sixty Day IL - Shoulder.

“My glove was down two more inches than it has been all year last start, and it's been trending that way all season. They show you this graph, and it’s been down -- so what do we do? Just bring the front arm up a little bit and go from there.” - Zack Wheeler after their win against the LA Angels in their game on Sunday. 

"The way that we came out of the Chicago series, and last night we got beat, and to say that we're going to come in here and win four games in a row would be a very tough task. We knew that, but splitting [the series] is something that we don't want to do either. We want to win as many games as possible. So winning Game 2, which would equal our first win, would give us a chance to win the series, and we want to win another series." - Torey Lovullo after his team split their double-header against the Giants on Saturday.

Kyle Schwarber (L) DH

Trea Turner (R) SS

Bryce Harper (L) RF

Alec Bohm (R) 1B

Edmundo Sosa (R) 3B

Bryan De La Cruz (R) LF

Bryson Stott (L) 2B

J.T. Realmuto (R) C

Derek Hill (R) CF

Ildemaro Vargas (S) 2B

Corbin Carroll (L) RF

Gabriel Moreno (R) C

Geraldo Perdomo (S) SS

Nolan Arenado (R) DH

Tim Tawa (R) 1B

Jose Fernandez (R) 3B

Jordan Lawlar (R) CF

Ryan Waldschmidt (R) LF

Batting Average:  Bryan De La Cruz (.333)

Hits:  Trea Turner (132)

Home Runs:  Kyle Schwarber (40)

RBI:  Kyle Schwarber (82)

Stolen Bases:  Bryson Stott (23)

Wins:  Cristopher Sánchez (16)

Saves:  Jhoan Duran (28)

ERA:  Bryse Wilson (0.00)

Batting Average:  Gabriel Moreno (.302)

Hits:  Corbin Carroll (122)

Home Runs:  Ketel Marte (21)

RBI:  Ketel Marte (67)

Stolen Bases:  Corbin Carroll (20)

Wins:  Eduardo Rodriguez (14)

Saves:  Paul Sewald (24)

ERA:  Justin Martinez (0.00)

Managers:

Philadelphia Phillies: Don Mattingly (Interim)

Arizona Diamondbacks: Torey Lovullo (10th season)