by Rod Pearson
Tuesday, Sep 23, 2025
Game Time: 1:00 pm ET, Sunday, September 28, 2025
Venue: Raymond James Stadium, Tampa, FL
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Eagles -3, Buccaneers +3; Over/Under: 43.5 points
Bet365: Point Spread: Eagles -3.5, Buccaneers +3.5; Over/Under: 43.5 points
BetMGM: Point Spread: Eagles -3.5, Buccaneers +3.5; Over/Under: 44 points
Season Record
Philadelphia Eagles: 3-0 (1st place, NFC East)
Tampa Bay Buccaneers: 3-0 (1st place, NFC South)
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Recent Form
Philadelphia Eagles: won their last game at home against the Los Angeles Rams 33-26.
Tampa Bay Buccaneers: won their last game at home against the New York Jets 29-27.
Philadelphia Eagles vs Tampa Bay Buccaneers Preview and Analysis
The Eagles are entering this game with a 3-0 record overall and they have a 1-0 record in their divisional games too. They are 2-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Los Angeles Rams 33-26. Jalen Hurts was the starting QB and he completed 21/32 passes for 226 passing yards, 3 touchdowns, and 0 interceptions. Saquon Barkley led the team in rushing yards with 46. A. J. Brown led the receivers with 109 receiving yards on 6 receptions and 1 TD. Cooper DeJean led the defense in that game with 5 solo tackles and 4 assisted tackles while Jordan Davis led the defense in sacks with 1. Zack Baun came away with the only interception for them in that one.
The Buccaneers are entering this game with a 3-0 record overall and they have a 1-0 record in their divisional games too. They are 1-0 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the New York Jets 29-27. Baker Mayfield was the starting QB and he completed 19/29 passes for 233 passing yards, 1 touchdown, and 0 interceptions. Bucky Irving led the team in rushing yards with 66. Emeka Egbuka led the receivers with 85 receiving yards on 6 receptions. Zyon McCollum led the defense in that game with 9 solo tackles and 0 assisted tackles while Lavonte David, Jacob Parrish, YaYa Diaby, and Antoine Winfield Jr. each led the defense in sacks with 1. Jamel Dean came away with the only interception for them in that one.
Eagles vs Buccaneers Prediction
The current betting odds have the Eagles listed as a 3 point favorite in this game according to Draftkings Sportsbook. The Eagles have looked great in their games this season with their 3-0 record overall which has them right at the top of the NFC East again. They have some good wins to open up the season too, beating the Chiefs on the road in week 2 and now coming off a huge comeback win against the Rams last week. They were down big at halftime, but the offense finally found a spark and the Eagles once again showed why they are the defending Super Bowl champions. This is still an Eagles team that can win games in many different ways and they have a big injury advantage over their opponent this week. Meanwhile, the Buccaneers have looked great in their games this season with their 3-0 record overall which has them right at the top of the NFC South and looking like the team to beat in that division once again. They haven't had a strong schedule to open up the season though, beating the Falcons, Texans, and now the Jets. They were also very fortunate in their win over the Jets, going into that game with a ton of key players missing and almost losing the game at the end too. The Buccaneers have a really good team this year, but they are in a bad situation here with all of the injuries they have. The best way to place a bet here is on the Eagles to cover the spread in this game.
Eagles Buccaneers Prediction: Our NFL Pick for Sunday, September 28, 2025 (1:00 pm ET start time) is Eagles 27 Buccaneers 20.
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NFL Betting Trends
Philadelphia Eagles: 14-3 ATS in games where the line is +3 to -3. 12-4 ATS off a home win. 10-3 ATS vs. good offensive teams - scoring 24 or more points/game. 4-1 UNDER against NFC South division opponents. 9-5 UNDER in a road game where the total is between 42.5 and 49 points.
Tampa Bay Buccaneers: 17-26 ATS versus poor offensive teams - averaging 4.75 yards/play or less. 19-30 ATS at home versus poor rushing defenses - allowing 4.5 rushing yards/carry or more. 48-29 UNDER against NFC East division opponents. 19-9 UNDER at home when playing against a top-level team (Win Pct. > 75%).
Key Injuries
Philadelphia Eagles: Z. Baun (LB) Injured - Knee. J. Campbell (LB) Injured - Triceps. A. Jackson (CB) Injured - Groin. L. Johnson (OT) Injured - Stinger. T. McKee (QB) Injured - Right Thumb. W. Shipley (RB) Injured - Oblique.
Tampa Bay Buccaneers: M. Evans (WR) Injured - Hamstring. L. Hall (DL) Injured - Groin. C. Izien (S) Injured - Quadricep. L. David (LB) Injured - Knee. C. Heck (OT) Injured - Knee. B. Mayfield (QB) Injured - Biceps. T. Wirfs (OT) Injured - Knee. C. Godwin Jr. (WR) Injured - Ankle.
Notable Quotes
“We've got so many good players on this team. At times, you can feel we’re being conservative. I don’t think it should be like that. Let your killers do their thing. play fast and play aggressive. I’m not saying that we haven’t been, but me personally, that’s what I would like.” - A.J. Brown after their win against the LA Rams in their last game.
“Three-and-0 is important. It's important to win in this league. A lot of teams be crying because they lost close games. We lost some last year. We're winning them this year, so we're extremely happy about that.” - Todd Bowles after his team’s win against the Jets in their last game.
Starting Lineups
Philadelphia Eagles
WR Brown, A.J.
WR Dotson, Jahan
WR Smith, DeVonta
TE Goedert, Dallas
QB Hurts, Jalen
RB Barkley, Saquon
Tampa Bay Buccaneers
WR Miller, Ryan
WR Egbuka, Emeka
WR Shepard, Sterling
TE Otton, Cade
QB Mayfield, Baker
RB Irving, Bucky
Statistical Leaders
Philadelphia Eagles
Passing: Jalen Hurts (479)
Rushing: Saquon Barkley (194)
Receiving: A.J. Brown (144)
Touchdowns: Jalen Hurts (4)
Tampa Bay Buccaneers
Passing: Baker Mayfield (615)
Rushing: Bucky Irving (174)
Receiving: Emeka Egbuka (181)
Touchdowns: Emeka Egbuka (3)
Coaches:
Philadelphia Eagles: Nick Sirianni (5th season)
Tampa Bay Buccaneers: Todd Bowles (4th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
