Philadelphia Eagles vs Kansas City Chiefs Prediction, Preview and Odds - 09/14/2025

Game Time: 4:25 pm ET, Sunday, September 14, 2025

Venue:  GEHA Field at Arrowhead Stadium, Kansas City, MO 

Where to Watch:  FOX

DraftKings:  Point Spread:  Eagles -1.5, Chiefs +1.5; Over/Under:  46.5 points

Bet365:  Point Spread:  Eagles -1, Chiefs +1; Over/Under:  47 points

BetMGM:  Point Spread:  Eagles -1, Chiefs +1; Over/Under:  47 points

Philadelphia Eagles:  1-0 (1st place, NFC East)

Kansas City Chiefs:  0-1 (4th place, AFC West)

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Philadelphia Eagles:  won their last game at home against the Dallas Cowboys 24-20.

Kansas City Chiefs:  lost their last game at a neutral site against the Los Angeles Chargers 27-21.

The Eagles are entering this game with a 1-0 record overall and they have a 1-0 record in their divisional games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Dallas Cowboys 24-20. Jalen Hurts was the starting QB and he completed 19/23 passes for 152 passing yards, 0 touchdowns, and 0 interceptions. Jalen Hurts led the team in rushing yards with 62 and 2 TDs. Jahan Dotson led the receivers with 59 receiving yards on 3 receptions. Zack Baun led the defense in that game with 6 solo tackles and 3 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

 

 

 

The Chiefs are entering this game with a 0-1 record overall and they have a 0-1 record in their divisional games too. They are 0-0 in their home games, 0-0 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Los Angeles Chargers 27-21. Patrick Mahomes was the starting QB and he completed 24/39 passes for 258 passing yards, 1 touchdown, and 0 interceptions. Patrick Mahomes led the team in rushing yards with 57 and 1 TD. Hollywood Brown led the receivers with 99 receiving yards on 10 receptions. Chamarri Conner led the defense in that game with 7 solo tackles and 2 assisted tackles while Drue Tranquill led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.

The current betting odds have the Chiefs listed as a 1.5 point underdog in this game according to Draftkings Sportsbook. The Chiefs have a 0-1 record overall this season and they didn't look good in their season opener. They opened the year with a tough divisional game in Brazil and they lost to the Chargers 27-21. The defense wasn't great and Mahomes along with the Chiefs offense did not look right. That was their first game since losing the Super Bowl so that could have been hanging over them, but that loss should wake them up with the defending Super Bowl champion Eagles coming into town. Meanwhile, the Eagles have a 1-0 record overall and they looked good in their season opener. They beat the Cowboys at home 24-20 and their offense looked great as the Cowboys couldn't stop them to start the game. The defense didn't look great though as the Cowboys were able to have their way with the Eagles on offense. That is going to be a big issue here as the Chiefs still have plenty of talent in their offense and they are going to bring their best effort at home in this revenge game. The Chiefs are also in desperate need of a win after the way they looked in week 1 so couple that with the Super Bowl loss and the Chiefs are going to want this game at home more. The best way to place a bet here is on the Chiefs to cover the spread in this game. 

Eagles Chiefs Prediction:  Our NFL Pick for Sunday, September 14, 2025 (4:25 pm ET start time) is Chiefs 21 Eagles 17.

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Philadelphia Eagles: 15-23 ATS against AFC West division opponents. 28-40 1H ATS off a home win against a division rival. 12-6 UNDER in road games. 8-4 UNDER on the road after playing a game at home. 

Kansas City Chiefs: 12-5 ATS in games where the line is +3 to -3. 4-1 ATS off an upset loss as a favorite. 3-0 ATS after a loss by 6 or less points. 13-6 UNDER in home games. 9-3 UNDER after playing a division game.

Philadelphia Eagles:  C. Williams (OT) Injured - Shoulder. D. Goedert (TE) Injured - Knee. T. McKee (QB) Injured - Thumb. W. Shipley (RB) Injured - Obliques. L. Dickerson (OG) Injured - Back. J. Hunt (LB) Injured - Hip.

Kansas City Chiefs:  J. Royals (WR) Injured - Knee. X. Worthy (WR) Injured - Shoulder. T. Smith (OG) Injured - Knee. D. Tranquill (LB) Injured - Knee. N. Bolton (LB) Injured - Biceps. H. Brown (WR) Injured - Ankle. C. Conner (CB) Injured - Wrist. A. Gillotte (DL) Injured - Elbow. O. Norman-Lott (DL) Injured - Ankle. J. Taylor (OT) Injured - Knee.

“Some weird circumstances tonight.” - Nick Sirianni after his team’s win against the Cowboys in their last game. 

“This will be a big lesson for us. They definitely came out with more energy than we did. We got to get better from the start.” - Patrick Mahomes after their loss against the LA Chargers in their last game. 

WR Brown, A.J. 

WR Dotson, Jahan

WR Smith, DeVonta

TE Goedert, Dallas

QB Hurts, Jalen

RB Barkley, Saquon

WR Smith-Schuster, JuJu

WR Worthy, Xavier

WR Brown, Hollywood

TE Kelce, Travis

QB Mahomes, Patrick

RB Pacheco, Isiah

Passing: J. Hurts (152)

Rushing: J. Hurts (62)

Receiving: J. Dotson (59)

Touchdowns: J. Hurts (2)

Passing: P. Mahomes (258)

Rushing: P. Mahomes (57)

Receiving: H. Brown (99)

Touchdowns: T. Kelce (1)

Coaches:

Philadelphia Eagles: Nick Sirianni (5th season)

Kansas City Chiefs: Andy Reid (13th season)