Philadelphia 76ers vs Indiana Pacers Prediction, Preview and Odds - 10/28/2026

Game Time: 7:00 pm ET, Wednesday, October 28, 2026

Venue:  Gainbridge Fieldhouse, Indianapolis, IN 

Where to Watch:  ESPN

DraftKings:  Point Spread:  76ers -4.5, Pacers +4.5; Over/Under:  237.5 points

Bet365:  Point Spread:  76ers -4.5, Pacers +4.5; Over/Under:  237.5 points

BetMGM:  Point Spread:  76ers -4.5, Pacers +4.5; Over/Under:  238.5 points

Philadelphia 76ers:  3-1 (1st place, Atlantic Division)

Indiana Pacers:  2-2 (3rd place, Central Division)

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Philadelphia 76ers:  3-1 last 4

Indiana Pacers:  2-2 last 4

The 76ers are entering this game with a 3-1 record overall this season and they are 1-0 in their road games this season where they will be in this game. They are entering this game off a loss against the Detroit Pistons. Tyrese Maxey led the team in points in that game with 29 while LeBron James was next on the team with 18 points. LeBron James led the team in assists in that game with 5 while Adem Bona led the team in rebounds with 13. They were 40% from the field, 25.9% from 3-point range, and 60.9% from the free throw line with their shots in that game. Their offense is averaging 110 PPG and their defense is allowing their opponents to average 107 PPG against them. The 76ers have an ATS record of 2-2 this season and their O/U record is 1-3.

The Pacers are entering this game with a 2-2 record overall this season and they are 0-1 in their home games this season where they will be in this game. They are entering this game off a loss against the Milwaukee Bucks. Tyrese Haliburton led the team in points in that game with 22 while Pascal Siakam was next on the team with 20 points. Tyrese Haliburton led the team in assists in that game with 9 while Pascal Siakam led the team in rebounds with 13. They were 40.6% from the field, 27.1% from 3-point range, and 61.1% from the free throw line with their shots in that game. Their offense is averaging 116.5 PPG and their defense is allowing their opponents to average 115 PPG against them. The Pacers have an ATS record of 2-2 this season and their O/U record is 2-2.

The current betting odds have the 76ers listed as a 4.5 point favorite in this game according to Draftkings Sportsbook. The 76ers have looked good in their games this season with their 3-1 record overall which has them right near the top of the East. They have been a good road team too with their 1-0 road record this year. Meanwhile, the Pacers haven't looked great in their games this season with their 2-2 record overall which has them right in the middle of the East. They haven't looked great on their home court either with their 0-1 home record this season. The Pacers are coming off a terrible season in which their best player was injured all year. They are off to a better start this season with him back in the lineup, but he is still going to need some time to get back into a groove after having last season off. They are coming off a loss to a bad Bucks team too and their defense hasn't looked great in their 4 games so far, that being a big issue for them over the last few years. The 76ers have been rolling to start the season and they have looked like one of the best teams in the NBA with their new lineup. They are coming off a loss to the Pistons in their last one which was their 1st loss of the season, but they will be looking to bounce back here. The Pistons have been rolling to start the season too, so this is a great opportunity for the 76ers to bounce back against a weaker opponent who is still trying to put things back together from 2 seasons ago. The best way to place a bet here is on the 76ers to cover the spread in this game. 

76ers Pacers Prediction:  Our NBA Pick for Wednesday, October 28, 2026 (7:00 pm ET start time) is 76ers 122 Pacers 115.

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Philadelphia 76ers: 20-12 ATS as a road favorite. 22-11 ATS vs. poor rebounding teams - outrebounded by opponents by 3+ per game. 17-8 UNDER on the road when the line is +3 to -3. 10-5 UNDER after playing 3 consecutive home games.

Indiana Pacers: 16-22 ATS when the line is +3 to -3. 3-6 ATS versus poor 3 point shooting teams - making 33% of their attempts or less. 1-4 ATS versus poor shooting teams - making 43% of their shots or less. 23-17 UNDER against Atlantic division opponents.

Philadelphia 76ers:  J. Embiid (C) Day To Day - Heel. J. Walker (SF) Day To Day - Knee. V. Edgecombe (SG) Day To Day - Abdomen. T. Fall (C) Day To Day - Quadriceps. D. Barlow (SF) Out - Back. A. Hukporti (C) Out For Season - Achilles.

Indiana Pacers:  A. Nembhard (SG) Day To Day - Neck. I. Zubac (C) Day To Day - Ankle. B. Sheppard (SG) Out - Meniscus. T. McConnell (PG) Day To Day - Hamstring. J. Furphy (SG) Out For Season - ACL.

"We've got to do it by committee. I mean, I think if you're missing some of your size and all that kind of stuff, obviously it becomes a problem. And all five guys got to rebound.” - Nick Nurse after his team’s loss against the Pistons in their game on Sunday.

"Just getting my legs back is the biggest thing. It'll take a couple weeks." - Tyrese Haliburton after their loss against the Bucks in their game on Monday.

PG Tyrese Maxey

SG VJ Edgecombe

SF Jaylen Brown

PF LeBron James

C Joel Embiid

PG Tyrese Haliburton

SG Andrew Nembhard

SF Aaron Nesmith

PF Pascal Siakam

C Ivica Zubac

PPG: Tyrese Maxey (28.8)

APG: LeBron James (5.7)

Reb/G: Joel Embiid (9.7)

PPG: Pascal Siakam (23.5)

APG: Tyrese Haliburton (9.5)

Reb/G: Ivica Zubac (9)

Coaches:

Philadelphia 76ers: Nick Nurse (4th season)

Indiana Pacers: Rick Carlisle (6th season)