Philadelphia 76ers vs Detroit Pistons Prediction, Preview and Odds - 11/04/2026

Game Time: 7:00 pm ET, Wednesday, November 4, 2026

Venue:  Little Caesars Arena, Detroit, MI 

Where to Watch:  ESPN

DraftKings:  Point Spread:  76ers +2.5, Pistons -2.5; Over/Under:  217.5 points

Bet365:  Point Spread:  76ers +2.5, Pistons -2.5; Over/Under:  217.5 points

BetMGM:  Point Spread:  76ers +2.5, Pistons -2.5; Over/Under:  217.5 points

Philadelphia 76ers:  7-1 (1st place, Atlantic Division)

Detroit Pistons:  6-1 (1st place, Central Division)

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Philadelphia 76ers:  7-1 last 8

Detroit Pistons:  6-1 last 7

The 76ers are entering this game with a 7-1 record overall this season and they are 3-0 in their road games this season where they will be in this game. They are entering this game on a 4 game winning streak with wins coming against the Indiana Pacers, the New York Knicks, the Charlotte Hornets, and the Chicago Bulls. Tyrese Maxey led the team in points in that game with 26 while Jaylen Brown was next on the team with 25 points. Tyrese Maxey led the team in assists in that game with 11 while Jaylen Brown led the team in rebounds with 11. They were 52.7% from the field, 35.5% from 3-point range, and 70.4% from the free throw line with their shots in that game. Their offense is averaging 110.9 PPG and their defense is allowing their opponents to average 105.1 PPG against them. The 76ers have an ATS record of 5-3 this season and their O/U record is 2-6.

The Pistons are entering this game with a 6-1 record overall this season and they are 2-0 in their home games this season where they will be in this game. They are entering this game on a 3 game winning streak with wins coming against the Charlotte Hornets, the Brooklyn Nets, and the Hornets again. Cade Cunningham led the team in points in that game with 33 while Duncan Robinson was next on the team with 24 points. Cade Cunningham and Daniss Jenkins each led the team in assists in that game with 7 while Ausar Thompson led the team in rebounds with 6. They were 57.3% from the field, 48.6% from 3-point range, and 80% from the free throw line with their shots in that game. Their offense is averaging 111.9 PPG and their defense is allowing their opponents to average 100.3 PPG against them. The Pistons have an ATS record of 6-1 this season and their O/U record is 3-4.

The current betting odds have the 76ers listed as a 2.5 point underdog in this game according to Draftkings Sportsbook. The 76ers have looked great in their games this season with their 7-1 record overall which has them right at the top of the East. They have been a great road team too with their 3-0 road record this year. Meanwhile, the Pistons have looked great in their games this season with their 6-1 record overall which has them right near the top of the East. They have looked good on their home court too with their 2-0 home record this season. The Pistons have been rolling in their games lately and they have a ton of momentum on their side with 3 wins in a row now. They were the best team in the East in the regular season last year and they are off to a really hot start, but they aren't the team leading the way. The 76ers have also been rolling with a great start to the season and they have the best record in the NBA at the moment. They have already taken down some really good teams with their new lineup and they have looked like one of the best teams in the NBA. Adding Jaylen Brown and LeBron James has really made them a true championship contender and their defense has been a big part of their success so far. They have a ton of momentum on their side with 4 wins in a row now and they are definitely going to bring their best effort here. Their only loss this season was against the Pistons, so the 76ers will be looking to get their revenge here. The best way to place a bet here is on the 76ers to cover the spread in this game. 

76ers Pistons Prediction:  Our NBA Pick for Wednesday, November 4, 2026 (7:00 pm ET start time) is 76ers 109 Pistons 105.

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Philadelphia 76ers: 16-25 ATS when the total is 210 to 219.5. 20-33 ATS revenging a home loss vs opponent. 6-15 ATS when playing against a top-level team (Win Pct. > 70%). 33-20 UNDER when the line is +3 to -3. 

Detroit Pistons: 32-14 ATS against Atlantic division opponents. 18-12 ATS vs. poor rebounding teams - outrebounded by opponents by 3+ per game. 28-18 UNDER against Atlantic division opponents. 23-16 UNDER when the total is 210 to 219.5. 11-5 UNDER when playing against a top-level team (Win Pct. > 70%).

Philadelphia 76ers:  D. Barlow (SF) Out - Back. A. Hukporti (C) Out For Season - Achilles.

Detroit Pistons:  I. Joe (SG) Out - Hip. J. Duren (C) Out - Hamstring.

“I feel he’s so much more of a confident guy that he’s gonna move the ball, get those things started early and throughout the course of the game, and then it’s almost like you feel that coming from him right away. He comes and gets the first bucket or two of the fourth, and you know, like, here it comes, here it comes.” - Nick Nurse after his team’s win against the Bulls in their game on Monday. 

"When we are defending at the level that we are capable of defending, and the shots are going, we are going to be a tough out. Our guys have completely bought into what is most important to the team, and for us, it's our identity of being defensive-minded." - J.B. Bickerstaff after his team’s win against the Hornets in their game on Monday. 

PG Tyrese Maxey

SG VJ Edgecombe

SF Jaylen Brown

PF LeBron James

C Joel Embiid

PG Cade Cunningham

SG Duncan Robinson

SF Ausar Thompson

PF John Collins

C Paul Reed

PPG: Tyrese Maxey (29.1)

APG: LeBron James (7.3)

Reb/G: Joel Embiid (9.2)

PPG: Cade Cunningham (23.7)

APG: Cade Cunningham (7.1)

Reb/G: Ausar Thompson (7.2)

Coaches:

Philadelphia 76ers: Nick Nurse (4th season)

Detroit Pistons: J.B. Bickerstaff (3rd season)