Philadelphia 76ers vs Boston Celtics Prediction, Preview and Odds - 04/21/2026

Game Time: 7:00 pm ET, Tuesday, April 21, 2026

Venue:  TD Garden, Boston, MA

Where to Watch:  Peacock, NBCSN

DraftKings:  Point Spread:  76ers +13.5, Celtics -13.5; Over/Under:  216.5 points

Bet365:  Point Spread:  76ers +13.5, Celtics -13.5; Over/Under:  216.5 points

BetMGM:  Point Spread:  76ers +13.5, Celtics -13.5; Over/Under:  216.5 points

Philadelphia 76ers:  45-37 (4th place, Atlantic Division)

Boston Celtics:  56-26 (1st place, Atlantic Division)

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Philadelphia 76ers:  5-5 last 10

Boston Celtics:  8-2 last 10

The 76ers are entering the playoffs with a 45-37 record overall this season and they were 22-19 in their road games where they will be in this game. They are entering this game off a loss against the Boston Celtics. Tyrese Maxey led the team in points in that game with 21 while Paul George was next on the team with 17 points. Tyrese Maxey led the team in assists in that game with 8 while Kelly Oubre Jr. led the team in rebounds with 7. They were 38.9% from the field, 17.4% from 3-point range, and 73.9% from the free throw line with their shots in that game. Their offense is averaging 115.9 PPG and their defense is allowing their opponents to average 116.1 PPG against them. The 76ers have an ATS record of 44-40 this season and their O/U record is 40-44.

The Celtics are entering the playoffs with a 56-26 record overall this season and they were 30-11 in their home games where they will be in this game. They are entering this game on a 3 game winning streak with wins coming against the New Orleans Pelicans, the Orlando Magic, and the Philadelphia 76ers. Jaylen Brown led the team in points in that game with 26 while Jayson Tatum was next on the team with 25 points. Jayson Tatum led the team in assists in that game with 7 while Jayson Tatum led the team in rebounds with 11. They were 50% from the field, 36.4% from 3-point range, and 77.3% from the free throw line with their shots in that game. Their offense is averaging 114.9 PPG and their defense is allowing their opponents to average 107.2 PPG against them. The Celtics have an ATS record of 50-33 this season and their O/U record is 30-53.

The current betting odds have the Celtics listed as a 13.5 point favorite in this game according to Draftkings Sportsbook. The Celtics have looked great in their games this season with their 56-26 record overall which had them right near the top of the East with one of the best records in the entire NBA. They have looked great on their home court too with their 30-11 home record this season. Meanwhile, the 76ers have looked good in their games this season with their 45-37 record overall which had them right in the middle of the East. They have been a good road team too with their 22-19 road record this year. This is game 2 of a 7-game series between the 2 seeded Celtics and the 7 seeded 76ers in the East for the 1st round of the NBA playoffs. The Celtics are entering this game with a 1-0 series lead after winning game 1 by a score of 123-91. The 76ers had to earn their spot in the playoffs by playing in the play-in tournament and they beat an up and down Magic team to get here, but they showed no life in game 1. They were down right from the start of that game and the Celtics never looked back, taking a double digit lead in the 1st quarter. The Celtics have been rolling lately with 3 wins in a row now and they are 8-2 in their last 10 games too. They have looked like the best team in the East this season and the 76ers are playing the start of this series shorthanded. Embiid missed the 1st game of this series and he will likely miss the next game too which is a huge blow since the 76ers just haven't looked the same without him. The 76ers showed no reasons why they would keep this 2nd game close on the road without Embiid, so look for the Celtics to roll over them again on their way to a 2-0 series lead. The best way to place a bet here is on the Celtics to cover the spread in this game. 

76ers Celtics Prediction:  Our NBA Pick for Tuesday, April 21, 2026 (7:00 pm ET start time) is Celtics 119  76ers 103.

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Philadelphia 76ers: 1-5 ATS as an underdog of 10 or more points. 5-12 ATS when playing against a good team (Win Pct. 60% to 70%). 9-17 ATS versus good teams - outscoring their opponents by 3+ points/game. 17-9 UNDER revenging a same season loss vs opponent. 17-10 UNDER versus good teams - outscoring their opponents by 3+ points/game.

Boston Celtics: 15-7 ATS as a favorite of 10 or more points. 26-15 ATS after playing a home game. 15-4 ATS when playing against a marginal winning team (Win Pct. 51% to 60%). 23-12 UNDER as a home favorite. 29-13 UNDER when playing against a team with a winning record.

Philadelphia 76ers:  J. Embiid (C) Day To Day - Abdomen. 

Boston Celtics:  None.

“We just didn't do enough at either end to settle into the game.” - Nick Nurse after his team’s loss against the Celtics in the 1st game of this series on Sunday. 

“That was Celtics basketball. We’ve been the harder-playing team all year. That can’t change now that the playoffs have started.” - Jaylen Brown after their win against the 76ers in game 1 of this series on Sunday. 

PG Tyrese Maxey

SG VJ Edgecombe

SF Kelly Oubre Jr.

PF Paul George

C Adem Bona

PG Derrick White 

SG Jaylen Brown 

SF Sam Hauser

PF Jayson Tatum

C Neemias Queta

PPG: Tyrese Maxey (28.3)

APG: Tyrese Maxey (6.6)

Reb/G: Andre Drummond (8.4)

PPG: Jaylen Brown (28.7)

APG: Derrick White (5.4)

Reb/G: Jayson Tatum (10)

Coaches:

Philadelphia 76ers: Nick Nurse (3rd season)

Boston Celtics: Joe Mazzulla (4th season)