Ottawa Senators vs Buffalo Sabres Prediction, Preview and Odds - 11/04/2026

Game Time: 7:30 pm ET, Wednesday, November 4, 2026

Venue:  KeyBank Center, Buffalo, NY 

Where to Watch:  ESPN+

DraftKings:  Moneyline:  Senators +110, Sabres -130; Over/Under:  6.5 goals

Bet365:  Moneyline:  Senators +110, Sabres -130; Over/Under:  6.5 goals

BetMGM:  Moneyline:  Senators +110, Sabres -130; Over/Under:  6.5 goals

Ottawa Senators:  9-6-1 (3rd place, Atlantic Division)

Buffalo Sabres:  7-4-3 (7th place, Atlantic Division)

Do not miss out on our expert handicapper analysis! ASA, Inc. is on a HOT STREAK in the NHL on a 7-2 NHL RUN for +$5,050 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Ottawa Senators:  4-5-1 last 10

Buffalo Sabres:  5-2-3 last 10

The Senators are entering this game with 19 points, a 9-6-1 record overall, and they are 4-4-1 in their road games this season where they will be in this game. They are entering this game off a loss against the Anaheim Ducks in their last game, losing that one on the road 6-3. Claude Giroux, Michael Amadio, and Philip Tomasino each scored 1 goal for them in that one. Jake Sanderson led the team in assists with 2 while Claude Giroux and Fabian Zetterlund each led the team in shots on net in that game with 3. Jonas Johansson was the starting goalie in that game and he allowed 6 goals on 33 shots with 27 saves and a .818 save percentage. Their offense has scored 52 goals this season averaging 3.3 goals per game and their defense has allowed their opponents to score 51 goals against them allowing 3.2 goals per game.

The Sabres are entering this game with 17 points, a 7-4-3 record overall, and they are 3-3-0 in their home games this season where they will be in this game. They are entering this game off a win against the Los Angeles Kings in their last game, winning that one on the road 3-2. Tage Thompson led the team in goals scored with 2 while Jack Quinn scored 1 goal for them in that one. Rasmus Dahlin and Zach Benson each led the team in assists with 2 while Tage Thompson led the team in shots on net in that game with 8. Ukko-Pekka Luukkonen was the starting goalie in that game and he allowed 2 goals on 29 shots with 27 saves and a .931 sv percentage. Their offense has scored 43 goals this season averaging 3.1 goals per game and their defense has allowed their opponents to score 49 goals against them allowing 3.5 goals per game.

The current betting odds have the Senators listed as a slight underdog in this game according to Draftkings Sportsbook. The Senators have looked good in their games this season with their 9-6-1 record overall which has them in the top half of their division in the East. They haven't been a great road team though with their 4-4-1 road record this year. Meanwhile, the Sabres haven't looked good in their games this season with their 7-4-3 record overall which has them right near the bottom of their division in the East. They haven't looked great on home ice either with their 3-3-0 home record this season. The Sabres are 5-3-2 in their last 10 games and they haven't looked good this season. They were one of the best teams in the East last season, but they haven't had a good start this year. They are coming off a 3-2 win over the Kings in their last one, but they haven't been scoring a ton of goals this season and their defense is still a big issue too, giving up more goals this year than they have been scoring. The Senators are 4-5-1 in their last 10 games and they haven't looked any better lately, but they did get off to a hot start this season. They are still near the top of the division too and their offense has looked a lot better this year. They also have some issues on defense, but they have been scoring a lot of goals. They are coming off a 6-3 loss to the Ducks in their last one, but they will be looking to bounce back here. Look for the Senators to bounce back in this one with a much better offense while the Sabres defense once again lets them down. The best way to place a bet here is on the Senators to win this game. 

Senators Sabres Prediction:  Our NHL Pick for Wednesday, November 4, 2026 (7:30 pm ET start time) is Senators 4 Sabres 3.

Don't miss our champion handicappers free picks and expert hockey picks today. And if you enjoyed this Ottawa Senators Buffalo Sabres prediction, be sure to drop by every day for our weekly NHL predictions and previews.

Ottawa Senators: 100-90 (-6.5 units) on the moneyline in all games. 17-30 (-8.6 units) on the moneyline as a road underdog. 52-55 (-9.3 units) on the moneyline against explosive offensive teams - scoring 3+ goals/game. 6-3 OVER when playing their 4th road game in 7 days.

Buffalo Sabres: 100-91 (+12.2 units) on the moneyline in all games. 46-29 (+9.1 units) on the moneyline as a favorite of -200 or less. 55-54 (+8.1 units) on the moneyline against explosive offensive teams - scoring 3+ goals/game. 30-16 OVER as a home favorite of -200 or less.

Ottawa Senators:  A. Burakovsky (LW) Out - Lower Body. W. Foegele (LW) Out - Knee. L. Ullmark (G) Out - Lower Body. W. Eklund (LW) Out - Ankle.

Buffalo Sabres:  Z. Benson (LW) Day To Day - Undisclosed. K. Helenius (C) Out - Upper-body. J. Danforth (RW) Out - Upper-Body. A. Lyon (G) Out - Upper-body. M. Grzelcyk (D) Out - Lower-Body. C. Timmins (D) Out - Lower-body. J. Rathbone (D) Out - Undisclosed.

"I liked a lot of our game. If you took the special teams out, I'd be really happy with the game." - Travis Green after his team’s loss against the Ducks in their game on Sunday. 

“You know, we’ve tried to run it out. We missed ‘Dahls’ for a couple games and got him back. You look at the power plays, the zone time, our entries. You put the work in, and we’re starting to see results.” - Lindy Ruff after his team’s win against the LA Kings in their game on Saturday. 

LW Fabian Zetterlund

C Tim Stutzle

RW Dylan Cozens

LD Jake Sanderson

RD Artyom Zub

G Jonas Johansson

LW Zach Benson

C Peyton Krebs

RW Tage Thompson

LD Rasmus Dahlin

RD Mattias Samuelsson

G Colten Ellis

Points: Tim Stutzle (21)

Goals: Tim Stutzle (9)

Assists: Tim Stutzle (12)

GAA: Linus Ullmark (1.33)

Points: Tage Thompson (17)

Goals: Tage Thompson (10)

Assists: Zach Benson (11)

GAA: Colten Ellis (3.11)

Coaches:

Ottawa Senators: Travis Green (3rd season)

Buffalo Sabres: Lindy Ruff (3rd season)