Oregon Ducks vs Penn State Nittany Lions Prediction, Picks and Game Preview - 09/27/2025

Game Time: 7:30 pm ET, Saturday, September 27, 2025

Venue:  Beaver Stadium, University Park, PA

Where to Watch:  NBC, Peacock

DraftKings:  Point Spread:  Oregon +3.5, PSU -3.5; Over/Under:  51.5 points

Bet365:  Point Spread:  Oregon +3.5, PSU -3.5; Over/Under:  52 points

BetMGM:  Point Spread:  Oregon +3.5, PSU -3.5; Over/Under:  51.5 points

Oregon Ducks:  4-0 (1-0) (2nd place, Big Ten)

Penn State Nittany Lions:  3-0 (0-0) (8th place, Big Ten)

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Oregon Ducks:  won their last game at home against the Oregon State Beavers 41-7.

Penn State Nittany Lions:  won their last game at home against the Villanova Wildcats 52-6.

Oregon is entering this game with a 4-0 record overall and they have a 1-0 record in their conference games too. They are 3-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Oregon State 41-7. Dante Moore was the starting QB and he completed 21/31 passes for 305 passing yards, 4 touchdowns, and 0 interceptions. Jayden Limar led the team in rushing yards with 70. Gary Bryant Jr. led the receivers with 65 receiving yards on 3 receptions and 1 TD. Bryce Boettcher led the defense in that game with 2 solo tackles and 8 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

 

 

 

Penn State is entering this game with a 3-0 record overall and they have a 0-0 record in their conference games too. They are 3-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Villanova 52-6. Drew Allar was the starting QB and he completed 16/29 passes for 209 passing yards, 1 touchdown, and 1 interception. Kaytron Allen led the team in rushing yards with 86 and 1 TD. Luke Reynolds led the receivers with 73 receiving yards on 4 receptions. Amare Campbell led the defense in that game with 7 solo tackles and 0 assisted tackles while Tony Rojas led the defense in sacks with 2. Jahmir Joseph came away with the only interception for them in that one.

The current betting odds have Penn State listed as a 3.5 point favorite in this game according to Draftkings Sportsbook. Penn State has looked good in their games this season with their 3-0 record overall. They haven't really played anyone of note yet, but they made a deep run in the playoffs last season and they are returning a lot of that talent this year. Penn State should be a lot more improved from last season and they are one of the teams to beat in the Big Ten this year. Meanwhile, Oregon has looked great in their games this season with their 4-0 record overall and they have been crushing a lot of their opponents to start the season. They haven't really played any good opponents yet either, but they do have a solid road win in the conference under their belt. That win was against Northwestern though and they are one of the worst teams in the Big Ten. Oregon has been one of the best teams in the nation over the last few years, but they lost a lot of talent from last season and beating up on bad teams hasn't really shown anything yet. Both of these teams have had bad schedules to start the season so this is going to be the first real test for both teams, but Penn State definitely has the advantage at home with the talent they brought back from last year. The best way to place a bet here is on Penn State to cover the spread in this game. 

Oregon Penn State Prediction:  Our NCAAF Pick for Saturday, September 27, 2025 (7:30 pm ET start time) is Penn State 24 Oregon 20.

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Oregon Ducks: 20-11 ATS in all lined games. 7-3 ATS in road lined games. 11-5 ATS after allowing 14 points or less last game. 6-2 ATS when playing against a top-level team (Win Pct. > 75%). 13-6 UNDER after a win by 17 or more points. 11-6 UNDER after scoring 37 points or more last game.

Penn State Nittany Lions: 3-6 ATS vs. good passing teams averaging 8 or more passing yards/att. 3-7 ATS when playing against a top-level team (Win Pct. > 75%). 1-6 ATS vs. good defensive teams who give up 17 or less points/game. 5-0 UNDER vs. good passing defenses - allowing 5.75 or less passing yards/att.

Oregon Ducks:  J. Lowe (WR) Questionable - Undisclosed. J. Ressler (WR) Questionable - Undisclosed. D. Gresham (WR) Questionable - Undisclosed. B. Boulton (OG) Questionable - Undisclosed. D. Brew (CB) Questionable - Undisclosed. B. Platt (LB) Questionable - Undisclosed. N. Whittington (RB) Questionable - Undisclosed. E. Stewart (WR) Out - Knee. T. McNutt (CB) Out - Leg.

Penn State Nittany Lions:  L. Samuel (WR) Questionable - Undisclosed. A. Olesh (TE) Questionable - Undisclosed. M. Outten (WR) Questionable - Undisclosed. B. Kritza (QB) Questionable - Undisclosed. R. Adirika (DL) Questionable - Undisclosed. L. Horan (OG) Questionable - Undisclosed. M. Granville (DL) Questionable - Undisclosed. L. Cunningham (WR) Questionable - Undisclosed. D. Cook (DL) Questionable - Undisclosed. P. Gonzalez (WR) Questionable - Undisclosed. K. Jackson (LB) Questionable - Undisclosed. B. O'Hara (OG) Questionable - Undisclosed. M. Williams (DL) Questionable - Undisclosed. J. Brown (WR) Questionable - Undisclosed. D. Nastasi (CB) Questionable - Undisclosed. M. Robinson (DL) Questionable - Undisclosed. J. Mayer (DL) Questionable - Undisclosed. A. Davis (RB) Questionable - Undisclosed. K. Artis (DL) Questionable - Undisclosed. K. Saunders (WR) Questionable - Undisclosed.

“Personally it was me remembering my 18-year-old self when I played at Oregon State, I was mentally depressed the way things were going. Everybody knows the struggles I was having, and I kind of just used that as fuel to make sure I never get that feeling again." - Dante Moore after their win against Oregon State in their last game. 

“I think we make it harder than it needs to be at times.” - James Franklin after his team’s win against Villanova in their last game. 

WR Benson, Malik

WR Moore, Dakorien

WR Bryant Jr., Gary

TE Sadiq, Kenyon

QB Moore, Dante

RB Whittington, Noah

WR Hudson, Kyron 

WR Clifford, Liam

WR Peña, Trebor 

TE Dinkins, Khalil 

QB Allar, Drew

RB Singleton, Nicholas

Passing: Dante Moore (962)

Rushing: Jayden Limar (215)

Receiving: Dakorien Moore (207)

Touchdowns: Jordon Davison (6)

Passing: Drew Allar (626)

Rushing: Kaytron Allen (273)

Receiving: Trebor Pena (166)

Touchdowns: Nicholas Singleton (5)

Coaches:

Oregon Ducks: Dan Lanning (4th season)

Penn State Nittany Lions: James Franklin (12th season)