by Rod Pearson
Monday, Sep 08, 2025
Game Time: 12:00 pm ET, Saturday, September 13, 2025
Venue: Northwestern Medicine Field at Martin Stadium, Evanston, IL
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Oregon -27.5, Northwestern +27.5; Over/Under: 51.5 points
Bet365: Point Spread: Oregon -27.5, Northwestern +27.5; Over/Under: 51 points
BetMGM: Point Spread: Oregon -28, Northwestern +28; Over/Under: 51.5 points
Season Record
Oregon Ducks: 2-0 (0-0) (2nd place, Big Ten)
Northwestern Wildcats: 1-1 (0-0) (17th place, Big Ten)
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Oregon Ducks: won their last game at home against the Oklahoma State Cowboys 69-3.
Northwestern Wildcats: won their last game at home against the Western Illinois Leathernecks 42-7.
Oregon Ducks vs Northwestern Wildcats Preview and Analysis
Oregon is entering this game with a 2-0 record overall and they have a 0-0 record in their conference games too. They are 2-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Oklahoma State 69-3. Dante Moore was the starting QB and he completed 16/21 passes for 266 passing yards, 3 touchdowns, and 0 interceptions. Noah Whittington led the team in rushing yards with 91 and 1 TD. Jeremiah McClellan led the receivers with 76 receiving yards on 2 receptions. Peyton Woodyard led the defense in that game with 3 solo tackles and 2 assisted tackles while Teitum Tuioti led the defense in sacks with 1. Peyton Woodyard and Jerry Mixon each came away with 1 interception for them in that one.
Northwestern is entering this game with a 1-1 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Western Illinois 42-7. Preston Stone was the starting QB and he completed 21/29 passes for 245 passing yards, 3 touchdowns, and 0 interceptions. Cam Porter led the team in rushing yards with 91 and 1 TD. Griffin Wilde led the receivers with 94 receiving yards on 5 receptions. Carmine Bastone, Robert Fitzgerald, and Dillon Tatum each led the defense in that game with 3 solo tackles and 1 assisted tackle while Carmine Bastone led the defense in sacks with 1.5. Mac Uihlein came away with the only interception for them in that one.
Oregon vs Northwestern Prediction
The current betting odds have Oregon listed as a 27.5 point favorite in this game according to Draftkings Sportsbook. Oregon has looked great in their games this season with their 2-0 record overall. They have blown out both opponents they have played so far and they look like they are once again a top team in the nation. They did open the season with a team from the FCS, but they played the team that went to the FCS Championship last year and blew them out of the water. They just beat Oklahoma State 69-3 in their last game now and even though this is their first road game of the season, it isn't going to be much of a test for them. Meanwhile, Northwestern hasn't looked great in their games this season with their 1-1 record overall. They just beat Western Illinois at home 42-7, but they got embarrassed in week 1 with a 23-3 loss on the road to Tulane. They are one of the worst teams in the Big Ten this season and couldn't even move the ball in week 1 against one of the best group of 5 teams in the nation. Now they have to play one of the best teams in the nation and a true contender to win the Big Ten. Northwestern isn't going to put up much of a fight against Oregon, even being at home, and Oregon is playing this season with something to prove. The best way to place a bet here is on Oregon to cover the spread in this game.
Oregon Northwestern Prediction: Our NCAAF Pick for Saturday, September 13, 2025 (12:00 pm ET start time) is Oregon 49 Northwestern 10.
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NCAAF Betting Trends
Oregon Ducks: 19-10 ATS in all lined games. 7-2 ATS as a road favorite. 6-1 ATS off a home blowout win by 28 points or more. 10-5 ATS after scoring 37 points or more last game. 6-3 UNDER as a road favorite. 11-6 UNDER after a win by 17 or more points.
Northwestern Wildcats: 0-3 ATS after a win by 17 or more points. 4-7 ATS after playing a game at home. 3-6 ATS in September games. 7-4 UNDER after 1 or more consecutive straight up wins. 8-4 1H UNDER in home lined games.
Key Injuries
Oregon Ducks: K. Rogers (OG) Questionable - Undisclosed. J. Ressler (WR) Questionable - Undisclosed. D. Gresham (WR) Questionable - Undisclosed. B. Boulton (OG) Questionable - Undisclosed. D. Brew (CB) Questionable - Undisclosed. B. Platt (LB) Questionable - Undisclosed. D. Williams (LB) Questionable - Undisclosed. A. Novosad (QB) Questionable - Undisclosed. E. Stewart (WR) Out - Knee. C. Johnson II (CB) Questionable - Undisclosed. J. Dickey (WR) Out - Suspension. T. McNutt (CB) Out - Leg.
Northwestern Wildcats: N. Glover (LB) Questionable - Undisclosed. C. Porter (RB) Questionable - Lower Body. J. Bailey (OG) Questionable - Undisclosed. D. Walters (CB) Questionable - Undisclosed. J. Borcherding (OG) Questionable - Undisclosed. M. Jackson (DL) Questionable - Undisclosed. F. Covey IV (WR) Questionable - Undisclosed. T. Kielmeyer (TE) Questionable - Undisclosed. N. Campbell (LB) Questionable - Undisclosed. C. O'Rourke (DL) Questionable - Undisclosed.
Notable Quotes
“I get excited when we play to the level we're capable of playing. And you may not realize it looking at it, but there's still some moments that I certainly want back. We had five penalties in the first half. In the second half we had one — that's our standard. But it's fun to win, right?” - Dan Lanning after his team’s win against Oklahoma State in their last game.
“He showed up at Sunday's practice flying around. I mean buzzing around on Monday, confident, resilient, excited to bounce back for this team.” - David Braun after his team’s win against Western Illinois in their last game.
Starting Lineups
Oregon Ducks
WR Benson, Malik
WR Moore, Dakorien
WR Bryant Jr., Gary
TE Sadiq, Kenyon
QB Moore, Dante
RB Whittington, Noah
Northwestern Wildcats
WR Ahumaraeze, Ricky
WR Covey IV, Frank
WR Wilde, Griffin
TE Albright, Lawson
QB Stone, Preston
RB Porter, Cam
Statistical Leaders
Oregon Ducks
Passing: D. Moore (479)
Rushing: N. Whittington (159)
Receiving: M. Benson (99)
Touchdowns: J. Davison (4)
Northwestern Wildcats
Passing: P. Stone (406)
Rushing: C. Porter (137)
Receiving: G. Wilde (158)
Touchdowns: C. Porter (1)
Coaches:
Oregon Ducks: Dan Lanning (4th season)
Northwestern Wildcats: David Braun (3rd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
