Oklahoma State Cowboys vs Oregon Ducks Prediction, Picks and Game Preview - 09/06/2025

Game Time: 3:30 pm ET, Saturday, September 6, 2025

Venue:  Autzen Stadium, Eugene, OR 

Where to Watch:  CBS, Paramount+

DraftKings:  Point Spread:  OK State +27.5, Oregon -27.5; Over/Under:  58.5 points

Bet365:  Point Spread:  OK State +27.5, Oregon -27.5; Over/Under:  57.5 points

BetMGM:  Point Spread:  OK State +28.5, Oregon -28.5; Over/Under:  57.5 points

Oklahoma State Cowboys:  1-0 (0-0) (10th place, SEC)

Oregon Ducks:  1-0 (0-0) (2nd place, Big Ten)

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Oklahoma State Cowboys:  won their last game at home against the Tennessee-Martin Skyhawks 27-7.

Oregon Ducks:  won their last game at home against the Montana State Bobcats 59-13.

Oklahoma State is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against UT-Martin 27-7. Hauss Hejny was the starting QB and he completed 5/10 passes for 96 passing yards, 1 touchdown, and 0 interceptions. Kalib Hicks led the team in rushing yards with 56. Terrill Davis led the receivers with 75 receiving yards on 2 receptions. Bryan McCoy led the defense in that game with 6 solo tackles and 8 assisted tackles while Wendell Gregory led the defense in sacks with 3. Kale Smith came away with the only interception for them in that one.

 

 

 

Oregon is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Montana State 59-13. Dante Moore was the starting QB and he completed 18/23 passes for 213 passing yards, 3 touchdowns, and 0 interceptions. Noah Whittington led the team in rushing yards with 68 and 1 TD. Malik Benson led the receivers with 51 receiving yards on 5 receptions and 1 TD. Dillon Thieneman led the defense in that game with 4 solo tackles and 0 assisted tackles while Matayo Uiagalelei led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.

The current betting odds have Oregon listed as a 27.5 point favorite in this game according to Draftkings Sportsbook. Oregon is 1-0 overall and they looked really good in their season opener. They did play a team from the FCS, but they played a really good FCS team that went to the FCS National Championship last year. Oregon looked really good in that game too, winning 59-13, and they look to be a force in the Big Ten this season once again. Meanwhile, Oklahoma State is 1-0 overall after winning at home in their season opener, but they weren't really tested in that game. They also played a team from the FCS, but they played a much weaker UT-Martin team and their offense still struggled to put up points. They beat them 27-7 and the defense looked good as they only gave up 7 points, but the offense wasn't nearly as dominant as it should have been. They didn't need to do much to win that game, but they weren't really tested at all and now they have to go on the road in their 2nd game, first road game of the season too, and play a ranked Oregon team that is one of the best in the nation. Oregon is still sour over the way their playoff campaign ended last season after being the number 1 team for most of the year so they aren't going to hold anything back in this game as they continue to play with a chip on their shoulder, trying to prove they are the best. Oklahoma State doesn't have the talent that Oregon has on their team and their offense just won't be able to compete on the road here. The best way to place a bet here is on Oregon to cover the spread in this game. 

Oklahoma State Oregon Prediction:  Our NCAAF Pick for Saturday, September 6, 2025 (3:30 pm ET start time) is Oregon 49 OK State 17.

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Oklahoma State Cowboys: 10-18 ATS in a road game where the total is between 56.5 and 63. 2-5 ATS as a road underdog. 6-2 UNDER in non-conference games. 3-0 UNDER after allowing 14 points or less last game.

Oregon Ducks: 18-10 ATS in all lined games. 17-9 ATS as a favorite. 10-4 ATS off a home win. 16-10 UNDER as a favorite. 11-5 UNDER after a win by 17 or more points.

Oklahoma State Cowboys:  D. Brown (DL) Questionable - Undisclosed. W. Gregory (LB) Questionable - Personal. R. Fields Jr. (RB) Questionable - Undisclosed. H. Hejny (QB) Out - Foot. T. Shettron (WR) Out - Knee.

Oregon Ducks:  D. Gresham (WR) Out - Undisclosed. E. Pregnon (OG) Questionable - Leg. D. Williams (LB) Questionable - Undisclosed. E. Stewart (WR) Out - Knee. J. Ressler (WR) Questionable - Undisclosed. B. Platt (LB) Questionable - Undisclosed. C. Johnson II (CB) Questionable - Undisclosed. D. Brew (CB) Questionable - Undisclosed. B. Boulton (OG) Questionable - Undisclosed. J. Dickey (WR) Out - Suspension. T. McNutt (CB) Out - Leg.

“Well, same thing as you. They’re a good football team. Oregon is playing really well. I think they’re well coached, they’re spending a lot of money, and they’ve put a lot into that organization. You can see they’re a good football team.” - Mike Gundy on his team’s upcoming game against Oregon this week.

“He was sharp. He knew where to go with the ball, was decisive with reads, was able to make some checks. I thought we had a simple plan and a plan we could execute at a high level. He went out there and executed it really well.” - Dan Lanning on Dante Moore after his team’s win against Montana State in their last game. 

WR Fitzpatrick, Christian

WR Davis, Terrill

WR Jackson V, Sam

TE Hammond, Oscar

QB Flores, Zane

RB Hicks, Kalib

WR Benson, Malik

WR Moore, Dakorien

WR Bryant Jr., Gary

TE Sadiq, Kenyon

QB Moore, Dante

RB Whittington, Noah

Passing: Z. Flores (136)

Rushing: K. Hicks (56)

Receiving: T. Davis (75)

Touchdowns: G. Freeman (1)

Passing: D. Moore (213)

Rushing: N. Whittington (68)

Receiving: M. Benson (51)

Touchdowns: J. Davison (3)

Coaches:

Oklahoma State Cowboys: Mike Gundy (21st season)

Oregon Ducks: Dan Lanning (4th season)