Oklahoma Sooners vs South Carolina Gamecocks Prediction, Picks and Game Preview - 10/18/2025

Game Time: 12:45 pm ET, Saturday, October 18, 2025

Venue:  Williams-Brice Stadium, Columbia, SC

Where to Watch:  SEC Network

DraftKings:  Point Spread:  Oklahoma -4.5, South Carolina +4.5; Over/Under:  43.5 points

Bet365:  Point Spread:  Oklahoma -4.5, South Carolina +4.5; Over/Under:  43 points

BetMGM:  Point Spread:  Oklahoma -4.5, South Carolina +4.5; Over/Under:  43.5 points

Oklahoma Sooners:  5-1 (1-1) (9th place, SEC)

South Carolina Gamecocks:  3-3 (1-3) (12th place, SEC)

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Oklahoma Sooners:  lost their last game at a neutral site against the Texas Longhorns 23-6.

South Carolina Gamecocks:  lost their last game on the road against the LSU Tigers 20-10.

Oklahoma is entering this game with a 5-1 record overall and they have a 1-1 record in their conference games too. They are 4-0 in their home games, 1-0 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Texas 23-6. John Mateer was the starting QB and he completed 20/38 passes for 202 passing yards, 0 touchdowns, and 3 interceptions. Tory Blaylock led the team in rushing yards with 33. Deion Burks led the receivers with 64 receiving yards on 5 receptions. Kendall Daniels Jr. led the defense in that game with 4 solo tackles and 2 assisted tackles while R Mason Thomas led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

South Carolina is entering this game with a 3-3 record overall and they have a 1-3 record in their conference games too. They are 2-1 in their home games, 0-2 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against LSU 20-10. LaNorris Sellers was the starting QB and he completed 15/27 passes for 124 passing yards, 0 touchdowns, and 1 interception. Matthew Fuller led the team in rushing yards with 83 and 1 TD. Nyck Harbor led the receivers with 36 receiving yards on 2 receptions. DQ Smith led the defense in that game with 3 solo tackles and 5 assisted tackles while no one on the defense recorded a sack for them. DQ Smith and Peyton Williams each came away with 1 interception for them in that one.

The current betting odds have Oklahoma listed as a 4.5 point favorite in this game according to Draftkings Sportsbook. Oklahoma has looked really good in their games this season with their 5-1 record overall, but their 1-1 conference record has them lower in the SEC. They were ranked inside the top 5 going into their last game, but they lost to Texas in the Red River Rivalry and they were never really in that game, losing 23-6. Their offense couldn't do much with Mateer back in the lineup, but the defense still looked great as they didn't give up many points. Mateer is still battling an injury too, but he will look better with another week of healing and they will be looking to bounce back in a big way. Meanwhile, South Carolina hasn't looked good in their games this season with their 3-3 record overall and their 1-3 conference record which has them right near the bottom of the SEC. They have looked better in their home games this season, but they are off a 20-10 loss to LSU in their last one and they struggled a lot against an elite defense. South Carolina's offense hasn't looked good all season with Sellers having a disappointing year, and they are about to see another elite defense in Oklahoma who might also have one of the best defenses in the nation. South Carolina has been a disaster since their season opener and this is a terrible game to be facing Oklahoma off a loss to their rival. The best way to place a bet here is on Oklahoma to cover the spread in this game. 

Oklahoma South Carolina Prediction:  Our NCAAF Pick for Saturday, October 18, 2025 (12:45 pm ET start time) is Oklahoma 24 South Carolina 10.

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Oklahoma Sooners: 7-3 ATS when the total is between 42.5 and 49. 5-0 ATS after a game with a turnover margin of -2 or worse. 14-8 ATS when playing with 6 or less days rest. 8-4 UNDER vs. good passing teams averaging 8 or more passing yards/att. 4-1 UNDER after a game with a turnover margin of -2 or worse. 

South Carolina Gamecocks: 4-7 ATS when playing against a top-level team (Win Pct. > 75%). 2-6 ATS versus good defensive teams - allowing 310 yards/game or less. 45-31 UNDER as an underdog of 3.5 to 10 points. 12-5 UNDER vs. good passing defenses - allowing 150 or less passing yards/game.

Oklahoma Sooners:  L. Howland (OG) Questionable - Undisclosed. J. Taylor (OG) Questionable - Undisclosed. J. Sexton (OG) Questionable - Undisclosed. K. McIntyre (TE) Questionable - Undisclosed. T. Everett (OG) Out - Undisclosed.

South Carolina Gamecocks:  C. Henry (OG) Questionable - Undisclosed. N. Hay (OG) Questionable - Undisclosed. M. Anderson (OG) Questionable - Undisclosed.

“Today was a bad day but we still have a good football team. Couldn't get any rhythm in the second half. They flipped the script. This one hurts for all the reasons we had opportunities.” - Brent Venables after his team’s loss against Texas in their last game. 

“I’m sick to my stomach that we didn’t win that football game. When we ran the ball, when we won the turnover battle, win time of possession — when you do all that, you should win the game.” - Shane Beamer after his team’s loss against LSU in their last game. 

WR Lewis, Keontez

WR Burks, Deion

WR Sategna III, Isaiah

TE Kanak, Jaren

QB Mateer, John

RB Blaylock, Tory

WR Harbor, Nyck

WR Jacobs, Vandrevius

WR Rowe Jr., Brian

TE Hunt, Brady

QB Sellers, LaNorris

RB Faison, Rahsul

Passing: John Mateer (1,417)

Rushing: Tory Blaylock (290)

Receiving: Isaiah Sategna III (420)

Touchdowns: John Mateer (5)

Passing: LaNorris Sellers (1,010)

Rushing: Rahsul Faison (231)

Receiving: Vandrevius Jacobs (341)

Touchdowns: Rahsul Faison (3)

Coaches:

Oklahoma Sooners: Brent Venables (4th season)

South Carolina Gamecocks: Shane Beamer (5th season)