Notre Dame Fighting Irish vs Stanford Cardinal Prediction, Picks and Game Preview - 11/29/2025

Game Time: 10:30 pm ET, Saturday, November 29, 2025

Venue:  Stanford Stadium, Stanford, CA

Where to Watch:  ESPN

DraftKings:  Point Spread:  Notre Dame -31.5, Stanford +31.5; Over/Under:  49.5 points

Bet365:  Point Spread:  Notre Dame -32, Stanford +32; Over/Under:  49.5 points

BetMGM:  Point Spread:  Notre Dame -32.5, Stanford +32.5; Over/Under:  49.5 points

Notre Dame Fighting Irish:  9-2 (0-0) (FBS Independent)

Stanford Cardinal:  4-7 (3-5) (12th place, ACC)

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Notre Dame Fighting Irish:  won their last game at home against the Syracuse Orange 70-7.

Stanford Cardinal:  won their last game at home against the California Golden Bears 31-10.

Notre Dame is entering this game with a 9-2 record overall and they have a 0-0 record in their conference games too. They are 6-1 in their home games, 3-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Syracuse 70-7. CJ Carr was the starting QB and he completed 5/9 passes for 49 passing yards, 1 touchdown, and 0 interceptions. Jeremiyah Love led the team in rushing yards with 171 and 3 TDs. Jordan Faison led the receivers with 21 receiving yards on 2 receptions. Jalen Stroman led the defense in that game with 8 solo tackles and 0 assisted tackles while Boubacar Traore, Madden Faraimo, and Drayk Bowen each led the defense in sacks with 1. Jalen Stroman, Ethan Long, and Leonard Moore each came away with 1 interception for them in that one.

 

 

 

Stanford is entering this game with a 4-7 record overall and they have a 3-5 record in their conference games too. They are 4-1 in their home games, 0-6 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against California 31-10. Elijah Brown was the starting QB and he completed 10/20 passes for 123 passing yards, 1 touchdown, and 0 interceptions. Micah Ford led the team in rushing yards with 150 and 1 TD. CJ Williams led the receivers with 76 receiving yards on 5 receptions and 1 TD. Brandon Nicholson led the defense in that game with 9 solo tackles and 0 assisted tackles while Brandon Nicholson, Matt Rose, and Ernest Cooper each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Notre Dame listed as a 31.5 point favorite in this game according to Draftkings Sportsbook. Notre Dame has looked great in their games this season with their 9-2 record overall which has them ranked inside the top 25 in a playoff spot at the moment. They have been a good road team too with their 3-1 road record this year. Meanwhile, Stanford hasn't looked great in their games this season with their 4-7 record overall and their 3-5 conference record which has them right near the bottom of the ACC. They have looked a lot better on their home field though with their 4-1 home record. Stanford is off a big 31-10 win over California in their last one and that was a game they put a ton of energy into winning. Now they really have nothing left to play for as they can't become bowl eligible. They have definitely been better in their home games, but they don't have the talent to compete with this Notre Dame team, and that offense has looked terrible for Stanford for most of the season. Notre Dame started the season 0-2, but they have won 9 games in a row now and they have been rolling lately. They are off a really impressive 70-7 win over Syracuse in their last one and they will be looking to cement their spot in the CFP with another big win in this game. Their offense has been rolling lately with the number of points they have been putting up in their games, and their defense hasn't been giving up many points either. The best way to place a bet here is on Notre Dame to cover the spread in this game. 

Notre Dame Stanford Prediction:  Our NCAAF Pick for Saturday, November 29, 2025 (10:30 pm ET start time) is Notre Dame 56 Stanford 10.

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Notre Dame Fighting Irish: 10-4 ATS against ACC opponents. 24-10 ATS as a favorite. 8-2 ATS off a home win by 17 points or more. 13-4 ATS after scoring 37 points or more last game. 22-14 OVER as a favorite.

Stanford Cardinal: 13-21 ATS in all lined games. 3-10 ATS when the total is between 49.5 and 56. 1-5 ATS off an upset win over a conference rival as an underdog. 6-11 ATS vs. good offensive  teams - scoring 31 or more points/game. 5-2 OVER when playing against a top-level team (Win Pct. > 75%).

Notre Dame Fighting Irish:  N. Burnette (K) Questionable - Right Hip. C. Flanagan (TE) Questionable - Achilles. T. Johnson (S) Questionable - Hand. C. Tucker (CB) Out - Undisclosed. K. Viliamu-Asa (LB) Out - Knee. S. Sevillano Jr. (DL) Out - Ankle. G. Rubio (DL) Out - Elbow. P. Jones (OG) Out - Ankle. C. Jagusah (OG) Out - Arm. B. Schrauth (OG) Out - Knee. A. Craig (OG) Out - Knee. K. Young (RB) Out - Knee. B. Logan (S) Out - Shoulder. D. Devezin (RB) Out - Shoulder.

Stanford Cardinal:  C. Richardson (CB) Questionable - Undisclosed. W. Aybar (LB) Questionable - Undisclosed. J. Onovughe (WR) Questionable - Undisclosed. T. Altahir (RB) Questionable - Undisclosed. J. Hall (WR) Questionable - Undisclosed. J. Leyrer (OG) Questionable - Undisclosed. N. Fattig (OG) Questionable - Undisclosed. N. Mejia (OG) Questionable - Undisclosed. R. Gaskins (DL) Questionable - Undisclosed. J. Randall (CB) Questionable - Undisclosed. D. Pantelis (WR) Out - Undisclosed.

“Obviously, unique game. I don’t know if I’ve ever seen a game like that, 21 points on the board and the offense hasn’t been on the field.” - Marcus Freeman after his team’s win against Syracuse in their last game. 

“Scoring two touchdowns, are you kidding me. We were struggling on offense. It’s one thing for the defense to keep you in the game while you’re struggling. It’s another thing for them to score two touchdowns and go in with a lead and you feel like you haven’t even made a first down. I just think that really kind of injected us with some confidence.” - Frank Reich after his team’s win against Cal in their last game. 

WR Fields, Malachi

WR Faison, Jordan

WR Greathouse, Jaden

TE Raridon, Eli

QB Carr, CJ

RB Love, Jeremiyah

WR Williams, CJ

WR Farrell, Bryce

WR High, Caden

TE Roush, Sam

QB Gulbranson, Ben

RB Ford, Micah

Passing: CJ Carr (2,536)

Rushing: Jeremiyah Love (1,306)

Receiving: Malachi Fields (608)

Touchdowns: Jeremiyah Love (20)

Passing: Ben Gulbranson (1,813)

Rushing: Micah Ford (643)

Receiving: CJ Williams (735)

Touchdowns: CJ Williams (6)

Coaches:

Notre Dame Fighting Irish: Marcus Freeman (5th season)

Stanford Cardinal: Frank Reich (Interim)