by Rod Pearson
Monday, Nov 10, 2025
Game Time: 12:00 pm ET, Saturday, November 15, 2025
Venue: Acrisure Stadium, Pittsburgh, PA
Where to Watch: ABC
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Notre Dame -11.5, Pittsburgh +11.5; Over/Under: 55.5 points
Bet365: Point Spread: Notre Dame -10.5, Pittsburgh +10.5; Over/Under: 55.5 points
BetMGM: Point Spread: Notre Dame -10.5, Pittsburgh +10.5; Over/Under: 55.5 points
Season Record
Notre Dame Fighting Irish: 7-2 (0-0) (FBS Independent)
Pittsburgh Panthers: 7-2 (5-1) (3rd place, ACC)
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Notre Dame Fighting Irish: won their last game at home against the Navy Midshipmen 49-10.
Pittsburgh Panthers: won their last game on the road against the Stanford Cardinal 35-20.
Notre Dame Fighting Irish vs Pittsburgh Panthers Preview and Analysis
Notre Dame is entering this game with a 7-2 record overall and they have a 0-0 record in their conference games too. They are 5-1 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Navy 49-10. CJ Carr was the starting QB and he completed 13/16 passes for 218 passing yards, 3 touchdowns, and 0 interceptions. Jeremiyah Love led the team in rushing yards with 94 and 2 TDs. Malachi Fields led the receivers with 97 receiving yards on 4 receptions. DeVonta Smith led the defense in that game with 4 solo tackles and 1 assisted tackle while Jaiden Ausberry and Junior Tuihalamaka each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Pittsburgh is entering this game with a 7-2 record overall and they have a 5-1 record in their conference games too. They are 4-1 in their home games, 3-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Stanford 35-20. Mason Heintschel was the starting QB and he completed 23/38 passes for 304 passing yards, 3 touchdowns, and 2 interceptions. Ja'Kyrian Turner led the team in rushing yards with 127. Kenny Johnson led the receivers with 71 receiving yards on 4 receptions and 1 TD. Kyle Louis led the defense in that game with 5 solo tackles and 5 assisted tackles while Jimmy Scott led the defense in sacks with 2. Kyle Louis, Shawn Lee Jr., and Javon McIntyre each came away with 1 interception for them in that one.
Notre Dame vs Pittsburgh Prediction
The current betting odds have Notre Dame listed as an 11.5 point favorite in this game according to Draftkings Sportsbook. Notre Dame has looked really good in their games this season with their 7-2 record overall which has them ranked inside the top 10 in the nation and looking to make the CFP. They started the season 0-2 with losses to Miami and Texas A&M, but they have been rolling now with 7 wins in a row. Meanwhile, Pittsburgh has looked really good in their games this season with their 7-2 record overall and their 5-1 conference record which has them right near the top of the ACC. They have looked great on their home field this year with their 4-1 home record and they have looked a lot better in their games since making a change at QB. They are off a 35-20 road win over Stanford and are now coming out of their bye week, but this is still a much bigger game for Notre Dame. Notre Dame has a spot in the playoffs with their current ranking and they don't play in a conference so every game matters to them and they can't afford to lose again with their strength of schedule too. A win here for Pittsburgh would be huge for their playoff hopes, but they could also lose this game and still end up in the ACC Championship with only 1 conference loss. There is simply more urgency for Notre Dame as they are in the same position as last season when they needed to run the table, and they still have a lot more talent on their team, blowing a lot of teams out in their games lately. The best way to place a bet here is on Notre Dame to cover the spread in this game.
Notre Dame Pittsburgh Prediction: Our NCAAF Pick for Saturday, November 15, 2025 (12:00 pm ET start time) is Notre Dame 45 Pittsburgh 27.
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NCAAF Betting Trends
Notre Dame Fighting Irish: 19-24 ATS off a home blowout win by 28 points or more. 23-15 OVER in all lined games. 7-3 OVER as a road favorite. 13-7 OVER after a win by 17 or more points. 11-6 OVER after scoring 37 points or more last game.
Pittsburgh Panthers: 13-5 ATS in home lined games. 4-1 ATS after 3 or more consecutive wins against the spread. 8-3 ATS versus good offensive teams - averaging 425 yards/game or more. 9-5 OVER as an underdog. 6-3 OVER vs. good teams - outscoring opponents by 10+ PPG on the season.
Key Injuries
Notre Dame Fighting Irish: D. Hinish (DL) Questionable - Undisclosed. J. Greathouse (WR) Questionable - Thigh. M. Gilbert (WR) Questionable - Hand. C. Flanagan (TE) Questionable - Achilles. B. Schrauth (OG) Out - Knee. A. Craig (OG) Out - Knee. K. Young (RB) Out - Knee. B. Logan (S) Out - Shoulder. D. Devezin (RB) Out - Shoulder.
Pittsburgh Panthers: C. Brookins (CB) Questionable - Undisclosed. B. Spires (DL) Questionable - Undisclosed. N. Lapi (LB) Questionable - Undisclosed. R. Biles (LB) Questionable - Undisclosed. J. Persi (OG) Questionable - Undisclosed. N. Maynard (CB) Questionable - Undisclosed. J. Brown (RB) Questionable - Undisclosed. D. Cook (DL) Questionable - Undisclosed. D. Reid (RB) Questionable - Undisclosed. Z. Crothers (DL) Out - Undisclosed. K. Gouveia (OG) Out - Leg. J. Marcelin (LB) Out - Undisclosed. J. Bonsu (LB) Out - Undisclosed. D. Davis Jr. (RB) Out - Knee.
Notable Quotes
“I'm obviously proud of the way our guys battled. It’s always a great challenge when you get ready to play Navy just because of the uniqueness of their schemes on both sides of the ball. It is difficult to prepare for because it’s not something you see every week and it’s a good team.” - Marcus Freeman after his team’s win against Northwestern in their last game.
“That’s probably the most disappointing thing but you live and learn. Young quarterback, he’s gotta learn how to just take what they’re giving you and not try to force things.” - Pat Narduzzi after his team’s win against Stanford in their last game.
Starting Lineups
Notre Dame Fighting Irish
WR Fields, Malachi
WR Faison, Jordan
WR Greathouse, Jaden
TE Raridon, Eli
QB Carr, CJ
RB Love, Jeremiyah
Pittsburgh Panthers
WR Johnson, Kenny
WR Hicks, Cataurus
WR Williams Jr., Raphael
TE Overman, Jake
QB Heintschel, Mason
RB Reid, Desmond
Statistical Leaders
Notre Dame Fighting Irish
Passing: CJ Carr (2,275)
Rushing: Jeremiyah Love (988)
Receiving: Jordan Faison (545)
Touchdowns: Jeremiyah Love (16)
Pittsburgh Panthers
Passing: Mason Heintschel (1,547)
Rushing: Ja'Kyrian Turner (399)
Receiving: Kenny Johnson (573)
Touchdowns: Raphael Williams Jr. (6)
Coaches:
Notre Dame Fighting Irish: Marcus Freeman (5th season)
Pittsburgh Panthers: Pat Narduzzi (11th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
