Notre Dame Fighting Irish vs Arkansas Razorbacks Prediction, Picks and Game Preview - 09/27/2025

Game Time: 12:00 pm ET, Saturday, September 27, 2025

Venue:  Donald W. Reynolds Razorback Stadium, Fayetteville, AR 

Where to Watch:  ABC

DraftKings:  Point Spread:  Notre Dame -6, Arkansas +6; Over/Under:  64.5 points

Bet365:  Point Spread:  Notre Dame -6, Arkansas +6; Over/Under:  64.5 points

BetMGM:  Point Spread:  Notre Dame -6, Arkansas +6; Over/Under:  64.5 points

Notre Dame Fighting Irish:  1-2 (0-0) (FBS Independent)

Arkansas Razorbacks:  2-2 (0-1) (14th place, SEC)

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Notre Dame Fighting Irish:  won their last game at home against the Purdue Boilermakers 56-30.

Arkansas Razorbacks:  lost their last game on the road against the Memphis Tigers 32-31.

Notre Dame is entering this game with a 1-2 record overall and they have a 0-0 record in their conference games too. They are 1-1 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Purdue 56-30. CJ Carr was the starting QB and he completed 10/12 passes for 223 passing yards, 2 touchdowns, and 0 interceptions. Jeremiyah Love led the team in rushing yards with 157 and 2 TDs. Jordan Faison led the receivers with 105 receiving yards on 5 receptions and 1 TD. Jalen Stroman led the defense in that game with 5 solo tackles and 1 assisted tackle while Bryce Young led the defense in sacks with 1. Dallas Golden and Christian Gray each came away with 1 interception for them in that one.

 

 

 

Arkansas is entering this game with a 2-2 record overall and they have a 0-1 record in their conference games too. They are 2-0 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Memphis 32-31. Taylen Green was the starting QB and he completed 18/34 passes for 325 passing yards, 1 touchdown, and 2 interceptions. Mike Washington Jr. led the team in rushing yards with 70 and 1 TD. Rohan Jones led the receivers with 102 receiving yards on 2 receptions and 1 TD. Larry Worth III led the defense in that game with 8 solo tackles and 1 assisted tackle while Quincy Rhodes Jr. led the defense in sacks with 2. Miguel Mitchell and Julian Neal each came away with 1 interception for them in that one.

The current betting odds have Notre Dame listed as a 6 point favorite in this game according to Draftkings Sportsbook. Notre Dame hasn't looked great in their games this season with their 1-2 record overall, but they are still hanging onto their ranking due to their tough schedule to start the season. They took 2 tough losses in close games against Miami and Texas A&M, losing one of those at home and the other on the road, but they finally got their first win of the season last week. They obliterated Purdue 56-30 and that win should give them some momentum coming into this one. Notre Dame is in a position now where they know they need to run the table and they can sense the blood in the water here with their opponent coming off a really bad loss. Meanwhile, Arkansas hasn't looked great in their games this season with their 2-2 record overall. They started the year with 2 big wins and their offense was rolling in those, but they were tripped up by Ole Miss in week 3. They lost a high scoring heartbreaker of a game against Ole Miss and were looking to bounce back last week, but once again a big mistake late in the game was costly as they went on to lose 32-31 against Memphis. Now this Arkansas team is reeling after 2 close losses and this is a great opportunity for Notre Dame to come in and get back to .500 with a big win against an opponent from the SEC. Look for Notre Dame to take advantage of Arkansas in this bad situation off 2 heartbreaking losses. The best way to place a bet here is on Notre Dame to cover the spread in this game. 

Notre Dame Arkansas Prediction:  Our NCAAF Pick for Saturday, September 27, 2025 (12:00 pm ET start time) is Notre Dame 45 Arkansas 31.

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Notre Dame Fighting Irish: 21-8 ATS in all lined games. 19-7 ATS as a favorite. 9-2 ATS vs. good offensive  teams - scoring 31 or more points/game. 21-11 OVER in all lined games. 7-3 OVER as a favorite of 3.5 to 10 points. 10-5 OVER after scoring 37 points or more last game.

Arkansas Razorbacks: 2-11 ATS in home lined games. 3-6 ATS after playing their last game on the road. 18-10 OVER in all lined games. 5-1 OVER as an underdog of 3.5 to 10 points. 6-2 OVER after playing their last game on the road.

Notre Dame Fighting Irish:  N. Burnette (K) Questionable - Undisclosed. D. Smith (CB) Questionable - Undisclosed. C. Flanagan (TE) Questionable - Achilles. C. Jagusah (OG) Questionable - Undisclosed. P. Jones (OG) Questionable - Ankle. J. Fisher (TE) Questionable - Knee. D. Houstan (OG) Questionable - Knee. K. Young (RB) Out - Knee. K. Bauman (TE) Out - Knee. B. Logan (S) Out - Shoulder. D. Devezin (RB) Out - Shoulder.

Arkansas Razorbacks:  C. Settles (RB) Questionable - Undisclosed. M. Harrison (WR) Questionable - Foot. K. Henderson (DL) Questionable - Undisclosed. M. Schueck (LB) Questionable - Undisclosed. I. Cisse (WR) Out - Wrist.

“It was a realistic understanding: Stop making yourself feel better by saying we're four points away from being 2-0, or, we're close. We're 0-2. You have to say that to them so they don't embrace it and understand the work they have to put in. That's what we needed at this moment. To be challenged and understand our backs are against the wall at this moment. How are we going to fight and get out of this.” - Marcus Freeman after his team’s win against Purdue in their last game. 

“At that point, the game was over. I saw it on the ground, and I was hoping at some point his knee was down.” - Sam Pittman after his team’s loss against Memphis in their last game. 

WR Fields, Malachi

WR Faison, Jordan

WR Greathouse, Jaden

TE Raridon, Eli

QB Carr, CJ

RB Love, Jeremiyah

WR Blake, O'Mega

WR Brown, Jalen

WR Brown, CJ

TE Jones, Rohan

QB Green, Taylen

RB Washington Jr., Mike

FB Lassiter, Maddox

Passing: CJ Carr (737)

Rushing: Jeremiyah Love (284)

Receiving: Malachi Fields (203)

Touchdowns: Jadarian Price (5)

Passing: Taylen Green (1,191)

Rushing: Taylen Green (360)

Receiving: O'Mega Blake (326)

Touchdowns: Mike Washington Jr. (5)

Coaches:

Notre Dame Fighting Irish: Marcus Freeman (5th season)

Arkansas Razorbacks: Sam Pittman (6th season)