North Carolina State Wolfpack vs Notre Dame Fighting Irish Prediction, Picks and Game Preview - 10/11/2025

Game Time: 3:30 pm ET, Saturday, October 11, 2025

Venue:  Notre Dame Stadium, Notre Dame, IN

Where to Watch:  Peacock

DraftKings:  Point Spread:  NC State +22.5, Notre Dame -22.5; Over/Under:  60.5 points

Bet365:  Point Spread:  NC State +22.5, Notre Dame -22.5; Over/Under:  60.5 points

BetMGM:  Point Spread:  NC State +22.5, Notre Dame -22.5; Over/Under:  60.5 points

North Carolina State Wolfpack:  4-2 (1-2) (11th place, ACC)

Notre Dame Fighting Irish:  3-2 (0-0) (FBS Independent)

Do not miss out on our expert handicapper analysis! Nelly’s Sports is on a HOT STREAK in college football on a 14-6-1 CFB RUN for +$7,450 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

North Carolina State Wolfpack:  won their last game at home against the Campbell Fighting Camels 56-10.

Notre Dame Fighting Irish:  won their last game at home against the Boise State Broncos 28-7.

NC State is entering this game with a 4-2 record overall and they have a 1-2 record in their conference games too. They are 3-1 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Campbell 56-10. CJ Bailey was the starting QB and he completed 20/23 passes for 337 passing yards, 4 touchdowns, and 0 interceptions. Daylan Smothers led the team in rushing yards with 123 and 1 TD. Noah Rogers led the receivers with 62 receiving yards on 3 receptions. Ronnie Royal III led the defense in that game with 4 solo tackles and 4 assisted tackles while Sabastian Harsh led the defense in sacks with 1.5. No one on the defense came away with an interception for them in that one.

 

 

 

Notre Dame is entering this game with a 3-2 record overall and they have a 0-0 record in their conference games too. They are 2-1 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Boise State 28-7. CJ Carr was the starting QB and he completed 15/23 passes for 189 passing yards, 2 touchdowns, and 0 interceptions. Jeremiyah Love led the team in rushing yards with 103 and 1 TD. Jordan Faison led the receivers with 83 receiving yards on 6 receptions. Leonard Moore led the defense in that game with 6 solo tackles and 0 assisted tackles while Jaylen Sneed, Jaiden Ausberry, and Drayk Bowen each led the defense in sacks with 1. Leonard Moore came away with 2 interceptions while Tae Johnson and Luke Talich each came away with 1 INT for them in that one.

The current betting odds have Notre Dame listed as a 22.5 point favorite in this game according to Draftkings Sportsbook. Notre Dame has looked good in their games this season with their 3-2 record overall which has them ranked inside the top 25 in the nation. They started the season 0-2, but both of their losses were against teams who are now in the top 10. They have won 3 games in a row now and have a ton of momentum on their side as they can still run the table and be a playoff team. Their offense has looked great in every game this season, but their defense has also looked a lot better in their last 2 games now. Meanwhile, NC State has looked good in their games this season with their 4-2 record overall, but their 1-2 conference record has them lower in the ACC. They are off a 56-10 win over Campbell in their last one, but they haven't had a really strong schedule to start the season and they have started to crumble now that the conference schedule has started. They have some bad losses under their belt too, losing their last ACC game at home to Wake Forest who is one of the worst teams in the conference, and their defense hasn't looked good against bad opponents either. Notre Dame is starting to roll now and they have a lot more talent on their team too, these are the games that they need to take care of business in if they want to be a playoff team at the end of the year. The best way to place a bet here is on Notre Dame to cover the spread in this game. 

North Carolina State Notre Dame Prediction:  Our NCAAF Pick for Saturday, October 11, 2025 (3:30 pm ET start time) is Notre Dame 49 NC State 20.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this North Carolina State Wolfpack Notre Dame Fighting Irish prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

North Carolina State Wolfpack: 2-6 ATS when the total is between 56.5 and 63. 2-10 ATS in non-conference games. 0-5 ATS after scoring 37 points or more last game. 0-4 ATS off a home win by 17 points or more. 6-1 OVER as a road underdog. 

Notre Dame Fighting Irish: 22-9 ATS in all lined games. 20-8 ATS as a favorite. 22-9 ATS in non-conference games. 10-3 ATS vs. good offensive  teams - scoring 31 or more points/game. 22-12 OVER in all lined games. 8-4 OVER against ACC opponents. 13-5 OVER after a win by 17 or more points.

North Carolina State Wolfpack:  R. Hinton (S) Questionable - Undisclosed. J. Bolder (WR) Questionable - Undisclosed. T. Mitchell (OG) Questionable - Undisclosed. T. West (OT) Questionable - Undisclosed. J. Paylor (WR) Questionable - Undisclosed. J. Sensabaugh (CB) Questionable - Undisclosed. S. Dixon (LB) Questionable - Undisclosed. B. Stukes (OG) Questionable - Undisclosed. C. Wilson (QB) Questionable - Undisclosed. A. Richardson (LB) Questionable - Undisclosed. I. Crowell (CB) Questionable - Undisclosed. J. Vick (CB) Questionable - Undisclosed.

Notre Dame Fighting Irish:  C. Flanagan (TE) Questionable - Achilles. N. Burnette (K) Questionable - Undisclosed. D. Smith (CB) Out - Calf. J. Greathouse (WR) Questionable - Undisclosed. P. Jones (OG) Questionable - Ankle. P. Zinter (LB) Questionable - Concussion. C. Jagusah (OG) Questionable - Arm. J. Fisher (TE) Questionable - Knee. K. Young (RB) Out - Knee. B. Logan (S) Out - Shoulder. D. Devezin (RB) Out - Shoulder.

“We needed to play well. We had a lot of ground to make up. We have to get better every week.” - Dave Doeren after his team’s win against Campbell in their last game. 

“To think where that defense was and how they felt two weeks ago, so after week two, A&M, after week three versus Purdue, to think about how … it was a low point for us all. And to see the way (the Notre Dame defense) stayed committed, stayed together. They worked tirelessly to come up with a better output. And I’m so proud of them. They worked hard.” - Marcus Freeman after his team’s win against BSU in their last game. 

WR Grimes, Wesley

WR Rogers, Noah

WR Jackson, Keenan

TE Joly, Justin

QB Bailey, CJ

RB Smothers, Hollywood

WR Fields, Malachi

WR Faison, Jordan

WR Greathouse, Jaden

TE Raridon, Eli

QB Carr, CJ

RB Love, Jeremiyah

Passing: CJ Bailey (1,660)

Rushing: Hollywood Smothers (693)

Receiving: Terrell Anderson (388)

Touchdowns: Hollywood Smothers (6)

Passing: CJ Carr (1,280)

Rushing: Jeremiyah Love (444)

Receiving: Jordan Faison (327)

Touchdowns: Jeremiyah Love (9)

Coaches:

North Carolina State Wolfpack: Dave Doeren (13th season)

Notre Dame Fighting Irish: Marcus Freeman (5th season)