New York Yankees vs St Louis Cardinals Prediction, Preview and Odds - 08/15/2025

Game Time: 8:15 pm ET, Friday, August 15, 2025

Venue:  Busch Stadium, St. Louis, MO

Where to Watch:  YES, FDSMW, KMOV

DraftKings:  Moneyline odds:  Yankees -137, Cardinals +113; Over/Under:  9 runs

Bet365:  Moneyline odds:  Yankees -130, Cardinals +110; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Yankees -130, Cardinals +110; Over/Under:  9 runs

New York Yankees:  64-57 (3rd place, AL East)

St Louis Cardinals:  61-61 (4th place, NL Central)

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New York Yankees:  4-6 last 10

St Louis Cardinals:  5-5 last 10

The Yankees are entering this series off a loss and won their 3-game series against the Minnesota Twins 2-1 in their last series. They enter this game with a 64-57 record overall and have a road record of 27-32. This is the series opener of a 3-game series with the Cardinals on Friday and they have Thursday off as a day of rest. Their offense ranks 1st in the MLB with a .774 OPS. Rookie pitcher Cam Schlittler was their starting pitcher on Wednesday while Luis Gil is making his start in this game on Friday. He is 0-1 with a 7.27 ERA this season. His team won their last game this season with him making an appearance. In his last MLB regular season start, he allowed 2 ER, 1 HR, and 1 BB with 7 SO on 6 hits through 5.1 IP against the Houston Astros.

The Cardinals are entering this series off a loss and lost their 3-game series against the Colorado Rockies 2-1 in their last series. They enter this game with a 61-61 record overall and have a home record of 35-27. This is the 1st game of a 3-game series with the Yankees on Friday and they have Thursday off as a day of rest. Their offense ranks 22nd in the MLB with a .704 OPS. Michael McGreevy was their starting pitcher on Wednesday while Andre Pallante is making his start in this game on Friday. He is 6-9 with a 4.95 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 6 earned runs, 1 homer, and 1 walk with 0 strikeouts on 7 hits through 1.2 innings pitched against the Chicago Cubs.

The current betting odds have the Yankees listed as a slight favorite in this game according to Draftkings Sportsbook. The Yankees have looked good in their games this season with their 64-57 record overall which has them right in the middle of the AL East and in the Wild Card race, They haven't been a great road team though with their 27-32 road record this season. Meanwhile, the Cardinals haven't looked great in their games this season with their 61-61 record overall which has them right near the bottom of the NL Central. They have looked a lot better in their own ballpark though with their 35-27 home record this year. The Cardinals are 5-5 in their last 10 games and have been the slightly hotter team lately as the Yankees are 4-6 in their last 10 and have been in a big slump lately, but the Cardinals are also slipping out of the Wild Card race and it doesn't help that they just lost a series at home to the Rockies who have the worst record in the MLB. Pallante is going to be starting for the Cardinals in this one and he hasn't looked great this season either. He is 6-9 with a 4.95 ERA and he has been giving up quite a few runs lately. His team has struggled with him lately, losing 2 games in a row now with him on the mound, and he is coming off another bad start in which he gave up 6 earned runs. Gil is on the mound for the Yankees in this one and he hasn't looked great this season. He is 0-1 with a 7.27 ERA, but he has also had just 2 starts this year. He looked a lot better in his last start too, only giving up 2 earned runs in a win for the Yankees so he will be looking to build on that here as the Yankees can take advantage of this series to get themselves back on track. The best way to place a bet here is on the Yankees to win this game. 

Yankees Cardinals Prediction:  Our MLB Pick for Friday, August 15, 2025 (8:15 pm ET start time) is Yankees 7 Cardinals 4.

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New York Yankees: 21-21 (-10.3 units) on the moneyline against NL Central opponents. 247-211 (-33.4 units) on the moneyline in all games. 184-148 (-44.9 units) on the moneyline as a favorite of -110 or higher. 23-14 OVER as a road favorite of -125 or more.

St Louis Cardinals: 22-17 (+9.2 units) on the moneyline against AL East opponents. 102-113 (+17.5 units) on the moneyline as an underdog of +100 or higher. 15-12 (+7.7 units) on the moneyline vs. AL teams scoring 4.9 or more runs/game on the season. 23-11 OVER in an inter-league game.

New York Yankees:  A. Rosario (3B) Ten Day IL - Joint. A. Slater (LF) Ten Day IL - Hamstring. J. Loaisiga (RP) Fifteen Day IL - Back. C. Schmidt (SP) Sixty Day IL - Forearm. F. Cruz (RP) Fifteen Day IL - Oblique. R. Yarbrough (SP) Fifteen Day IL - Oblique. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. G. Cole (SP) Sixty Day IL - Elbow.

St Louis Cardinals:  W. Contreras (1B) Day To Day - Foot. N. Arenado (3B) Ten Day IL - Shoulder. J. King (RP) Fifteen Day IL - Oblique. Z. Thompson (RP) Sixty Day IL - Lat.

“The fastball, it’s always good, but it plays up in the zone. He’s really good down with it, just with that angle he creates, and then he can work in the secondary off that. I thought he was really good. The first three innings, he was just cruising through.” - Aaron Boone after his team’s loss against the Twins in their game on Wednesday.

“Usually when you have the range and arm and you get to what he gets to, it comes with a lot of errors. Not because you’re not a good defender, but because you do things others can’t, and it leads to a throw getting away. The fact that he gets to more than anybody and he’s still securing the baseball, it’s highly impressive.” - Oliver Marmol after his team’s loss against the Rockies in their game on Wednesday.

Trent Grisham (L) CF

Aaron Judge (R) DH

Cody Bellinger (L) LF

Giancarlo Stanton (R) RF

Ben Rice (L) 1B

Jazz Chisholm Jr. (L) 2B

Anthony Volpe (R) SS

Ryan McMahon (L) 3B

Austin Wells (L) C

Brendan Donovan (L) 2B

Iván Herrera (R) LF

Masyn Winn (R) SS

Alec Burleson (L) 1B

Nolan Gorman (L) DH

Jordan Walker (R) RF

Lars Nootbaar (L) CF

Thomas Saggese (R) 3B

Pedro Pagés (R) C

Batting Average:  Amed Rosario (.429)

Hits:  Aaron Judge (134)

Home Runs:  Aaron Judge (38)

RBI:  Aaron Judge (88)

Stolen Bases:  Jasson Domínguez (19)

Wins:  Max Fried (12)

Saves:  Devin Williams (17)

ERA:  Adam Ottavino (0.00)

Batting Average:  José Fermín (.350)

Hits:  Brendan Donovan (118)

Home Runs:  Willson Contreras (16)

RBI:  Willson Contreras (65)

Stolen Bases:  Victor Scott (31)

Wins:  Sonny Gray (11)

Saves:  Ryan Helsley (21)

ERA:  Jorge Alcala (0.00)

Managers:

New York Yankees: Aaron Boone (8th season)

St Louis Cardinals: Oliver Marmol (4th season)