New York Yankees vs Houston Astros Prediction, Preview and Odds - 09/03/2025

Game Time: 8:10 pm ET, Wednesday, September 3, 2025

Venue:  Daikin Park, Houston, TX 

Where to Watch:  MLB Network, Prime Video

DraftKings:  Moneyline odds:  Yankees -126, Tigers +104; Over/Under:  9 runs

Bet365:  Moneyline odds:  Yankees -125, Tigers +105; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Yankees -125, Tigers +105; Over/Under:  9 runs

New York Yankees:  76-61 (2nd place, AL East)

Houston Astros:  76-62 (1st place, AL West)

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New York Yankees:  7-3 last 10

Houston Astros:  6-4 last 10

The Yankees are entering this series off a loss and won their 4-game series against the Chicago White Sox 3-1 in their last series. They enter this game with a 76-61 record overall and have a road record of 35-33. This is the 2nd game of a 3-game series with the Astros on Wednesday with the series opener still to be played on Tuesday. Their offense ranks 1st in the MLB with a .787 OPS. Max Fried is their starting pitcher on Tuesday while Will Warren is making his start in this game on Wednesday. He is 8-6 with a 4.30 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 0 ER, 1 HR, and 2 BB with 3 SO on 5 hits through 5 IP against the Chicago White Sox.

The Astros are entering this series off a win and split their 4-game series against the Los Angeles Angels 2-2 in their last series. They enter this game with a 76-62 record overall and have a home record of 42-30. This is the 2nd game of a 3-game series with the Yankees on Wednesday with the 2nd game of this series still to be played on Tuesday. Their offense ranks 13th in the MLB with a .720 OPS. Framber Valdez is their starting pitcher on Tuesday while Jason Alexander is making his start in this game on Wednesday. He is 4-1 with a 4.61 ERA this season. His team won their last 6 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 2 homers, and 1 walk with 8 strikeouts on 7 hits through 5.2 innings pitched against the Colorado Rockies.

The current betting odds have the Astros listed as a slight underdog in this game according to Draftkings Sportsbook. The Astros have looked great in their games this season with their 76-62 record overall which has them right at the top of the AL West. They have looked good in their own ballpark too with their 42-30 home record this year. Meanwhile, the Yankees have looked really good in their games this season with their 76-61 record overall which has them right near the top of the AL East. They have been a good road team too with their 35-33 road record this season. The Yankees have been the hotter team coming into this series as they are 7-3 in their last 10 games, but the Astros are 6-4 in their last 10 and have also looked good lately. Neither team has a great starter in this one, but both have looked a lot better as of late. The Yankees are going with Warren in this one and he has looked better lately. He is 8-6 with a 4.30 ERA, giving up no runs in his last start, and the team has won 3 of their last 4 games with him starting too. He does have 6 losses though and the Astros definitely have the edge with their bullpen if the starters get into trouble here. Alexander is on the mound for the Astros in this one and he has also looked better lately. He is 4-1 with a 4.61 ERA, but the team has had a ton of success with him. The team has won 6 games in a row now with him starting and even though he gave up 3 earned runs in his last start, he will be looking to bounce back at home with a better start and has the better bullpen behind him. The best way to place a bet here is on the Astros to win this game. 

Yankees Astros Prediction:  Our MLB Pick for Wednesday, September 3, 2025 (8:10 pm ET start time) is Astros 7 Yankees 4.

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New York Yankees: 259-215 (-27.3 units) on the moneyline in all games. 195-151 (-38.8 units) on the moneyline as a favorite of -110 or higher. 70-69 (-7.4 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 21-11 OVER on the road with a money line of -100 to -150.

Houston Astros: 73-52 (+36.3 units) on the moneyline as an underdog of +100 or higher. 133-108 (+14 units) on the moneyline when playing against a team with a winning record. 83-67 (+10.7 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 34-19 OVER vs. an AL team with a slugging percentage of .440 or better on the season.

New York Yankees:  B. Headrick (RP) Fifteen Day IL - Forearm. A. Slater (LF) Ten Day IL - Hamstring. J. Loaisiga (RP) Fifteen Day IL - Back. C. Schmidt (SP) Sixty Day IL - Forearm. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. G. Cole (SP) Sixty Day IL - Elbow.

Houston Astros:  V. Caratini (C) Seven Day IL - Concussion. J. Rooney (SP) Fifteen Day IL - Concussion / Nasal. B. Sousa (RP) Fifteen Day IL - Elbow. B. Walter (RP) Sixty Day IL - Elbow. J. Hader (RP) Fifteen Day IL - Shoulder. I. Paredes (3B) Sixty Day IL - Hamstring. B. Rodgers (2B) Sixty Day IL - Oblique. J. Meyers (CF) Ten Day IL - Calf. Z. Dezenzo (RF) Sixty Day IL - Hand. P. Leon (RF) Sixty Day IL - Knee. R. Blanco (SP) Sixty Day IL - Elbow. H. Wesneski (RP) Sixty Day IL - Elbow.

"We think we have a really good team. But we’ve got to continue to go prove it. We have that opportunity to prove it here in the final month of the season and hopefully beyond.” - Aaron Boone on his team’s play over the last 2 weeks. 

“Just to see him go out there and compete, to see the smile on his face, proud of him. He really worked hard to get to this point. I thought he threw the ball really well. He got the cutter, threw his fastball up in the zone when he needed. Very efficient when he stayed away from the middle of the plate.” - Joe Espada on Luis Garcia after his team’s win against the LA Angels in their game on Monday.

Paul Goldschmidt (R) 1B

Aaron Judge (R) DH

Cody Bellinger (L) CF

Giancarlo Stanton (R) RF

Amed Rosario (R) 3B

Jazz Chisholm Jr. (L) 2B

Anthony Volpe (R) SS

Ben Rice (L) C

José Caballero (R) LF

Jeremy Peña (R) SS

Yordan Alvarez (L) LF

Jose Altuve (R) DH

Carlos Correa (R) 3B

Christian Walker (R) 1B

Yainer Diaz (R) C

Ramón Urías (R) 2B

Cam Smith (R) RF

Mauricio Dubón (R) CF

Batting Average:  Amed Rosario (.389)

Hits:  Aaron Judge (149)

Home Runs:  Aaron Judge (43)

RBI:  Aaron Judge (97)

Stolen Bases:  Jazz Chisholm (25)

Wins:  Carlos Rodón (15)

Saves:  Devin Williams (18)

ERA:  Adam Ottavino (0.00)

Batting Average:  Jake Meyers (.308)

Hits:  Jose Altuve (141)

Home Runs:  Jose Altuve (24)

RBI:  Christian Walker (74)

Stolen Bases:  Jeremy Peña (20)

Wins:  Framber Valdez (12)

Saves:  Josh Hader (28)

ERA:  Craig Kimbrel (0.00)

Managers:

New York Yankees: Aaron Boone (8th season)

Houston Astros: Joe Espada (2nd season)