New York Yankees vs Houston Astros Prediction, Preview and Odds - 09/02/2025

Game Time: 8:10 pm ET, Tuesday, September 2, 2025

Venue:  Daikin Park, Houston, TX 

Where to Watch:  TBS, truTV

DraftKings:  Moneyline odds:  Yankees -119, Tigers -102; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Yankees -115, Tigers -105; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Yankees -115, Tigers -105; Over/Under:  7.5 runs

New York Yankees:  76-61 (2nd place, AL East)

Houston Astros:  76-62 (1st place, AL West)

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New York Yankees:  7-3 last 10

Houston Astros:  6-4 last 10

The Yankees are entering this series off a loss and won their 4-game series against the Chicago White Sox 3-1 in their last series. They enter this game with a 76-61 record overall and have a road record of 35-33. This is the series opener of a 3-game series with the Astros on Tuesday and they have Monday off as a day of rest. Their offense ranks 1st in the MLB with a .787 OPS. Luis Gil was their starting pitcher on Sunday while Max Fried is making his start in this game on Tuesday. He is 14-5 with a 3.06 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 0 HR, and 2 BB with 6 SO on 4 hits through 7 IP against the Washington Nationals.

The Astros are entering this series off a win and split their 4-game series against the Los Angeles Angels 2-2 in their last series. They enter this game with a 76-62 record overall and have a home record of 42-30. This is the 1st game of a 3-game series with the Yankees on Tuesday. Their offense ranks 13th in the MLB with a .720 OPS. Luis Garcia was their starting pitcher on Monday while Framber Valdez is making his start in this game on Tuesday. He is 12-7 with a 3.18 ERA this season. His team lost 5 of their last 6 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 2 walks with 5 strikeouts on 3 hits through 7 innings pitched against the Colorado Rockies.

The current betting odds have the Astros listed as a slight underdog in this game according to Draftkings Sportsbook. The Astros have looked great in their games this season with their 76-62 record overall which has them right at the top of the AL West. They have looked good in their own ballpark too with their 42-30 home record this year. Meanwhile, the Yankees have looked really good in their games this season with their 76-61 record overall which has them right near the top of the AL East. They have been a good road team too with their 35-33 road record this season. The Yankees have been getting really hot lately as they are 7-3 in their last 10 games, but the Astros are also 6-4 in their last 10 and they always give the Yankees some trouble. Fried is on the mound for the Yankees and he has looked great this season. He is 14-5 with a 3.06 ERA and he hasn't been giving up many runs this year. He is coming off another good start in which he gave up no runs and the team has won 2 of their last 3 games with him starting too. The Astros are going with Valdez in this one and he has also looked good this season. He is 12-7 with a 3.18 ERA and the team hasn't had much success with him lately. They have lost 5 of their last 6 games with him starting, but he is coming off a great start in which he gave up no runs and that has been a common theme for him this year. Both of these starters have been great and the Yankees do have the better offense here, but Fried still hasn't been at his best over the last month and the Astros have the edge being at home. The best way to place a bet here is on the Astros to win this game. 

Yankees Astros Prediction:  Our MLB Pick for Tuesday, September 2, 2025 (8:10 pm ET start time) is Astros 4 Yankees 3.

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New York Yankees: 259-215 (-27.3 units) on the moneyline in all games. 195-151 (-38.8 units) on the moneyline as a favorite of -110 or higher. 49-53 (-29.7 units) on the moneyline against left-handed starters. 21-11 OVER on the road with a money line of -100 to -150.

Houston Astros: 73-52 (+36.3 units) on the moneyline as an underdog of +100 or higher. 133-108 (+14 units) on the moneyline when playing against a team with a winning record. 83-67 (+10.7 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 34-19 OVER vs. an AL team with a slugging percentage of .440 or better on the season.

New York Yankees:  B. Headrick (RP) Fifteen Day IL - Forearm. A. Slater (LF) Ten Day IL - Hamstring. J. Loaisiga (RP) Fifteen Day IL - Back. C. Schmidt (SP) Sixty Day IL - Forearm. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. G. Cole (SP) Sixty Day IL - Elbow.

Houston Astros:  V. Caratini (C) Seven Day IL - Concussion. J. Rooney (SP) Fifteen Day IL - Concussion / Nasal. B. Sousa (RP) Fifteen Day IL - Elbow. B. Walter (RP) Sixty Day IL - Elbow. J. Hader (RP) Fifteen Day IL - Shoulder. I. Paredes (3B) Sixty Day IL - Hamstring. B. Rodgers (2B) Sixty Day IL - Oblique. J. Meyers (CF) Ten Day IL - Calf. Z. Dezenzo (RF) Sixty Day IL - Hand. P. Leon (RF) Sixty Day IL - Knee. R. Blanco (SP) Sixty Day IL - Elbow. H. Wesneski (RP) Sixty Day IL - Elbow.

"We think we have a really good team. But we’ve got to continue to go prove it. We have that opportunity to prove it here in the final month of the season and hopefully beyond.” - Aaron Boone on his team’s play over the last 2 weeks. 

“I think that we’ve been through some stretches of, ‘Here we go, right?’ We’re starting to click and then we run into a couple of decent arms and we haven’t been able to do much offensively. We’re going into September. It’s go time. Pretty much, that’s it. This is an offense that’s been good for a long time. We added a right-handed hitter in Correa, who’s been here before and he knows what we’re all about. We’ll get it going here. We’ll put this month behind us and this is when we play our best, in September.” - Joe Espada after his team’s loss against the LA Angels in their game on Sunday.

Paul Goldschmidt (R) 1B

Aaron Judge (R) DH

Cody Bellinger (L) CF

Giancarlo Stanton (R) RF

Amed Rosario (R) 3B

Jazz Chisholm Jr. (L) 2B

Anthony Volpe (R) SS

Ben Rice (L) C

José Caballero (R) LF

Jeremy Peña (R) SS

Yordan Alvarez (L) LF

Jose Altuve (R) DH

Carlos Correa (R) 3B

Christian Walker (R) 1B

Yainer Diaz (R) C

Ramón Urías (R) 2B

Cam Smith (R) RF

Mauricio Dubón (R) CF

Batting Average:  Amed Rosario (.389)

Hits:  Aaron Judge (149)

Home Runs:  Aaron Judge (43)

RBI:  Aaron Judge (97)

Stolen Bases:  Jazz Chisholm (25)

Wins:  Carlos Rodón (15)

Saves:  Devin Williams (18)

ERA:  Adam Ottavino (0.00)

Batting Average:  Jake Meyers (.308)

Hits:  Jose Altuve (141)

Home Runs:  Jose Altuve (24)

RBI:  Christian Walker (74)

Stolen Bases:  Jeremy Peña (20)

Wins:  Framber Valdez (12)

Saves:  Josh Hader (28)

ERA:  Craig Kimbrel (0.00)

Managers:

New York Yankees: Aaron Boone (8th season)

Houston Astros: Joe Espada (2nd season)