New York Yankees vs Cleveland Guardians Prediction, Preview and Odds - 06/10/2026

Game Time: 1:10 pm ET, Wednesday, June 10, 2026

Venue:  Progressive Field, Cleveland, OH

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Yankees +100, Guardians -120; Over/Under:  8 runs

Bet365:  Moneyline odds:  Yankees +100, Guardians -120; Over/Under:  7.5 runs

BetMGM:  Moneyline odds:  Yankees +100, Guardians -120; Over/Under:  7.5 runs

New York Yankees:  39-26 (2nd place, AL East)

Cleveland Guardians:  37-31 (1st place, AL Central)

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New York Yankees:  6-4 last 10

Cleveland Guardians:  4-6 last 10

The Yankees are entering this series off a win and split their 2-game series against the Boston Red Sox 1-1 in their last series. They enter this game with a 39-26 record overall and have a road record of 20-14. This is the series finale of a 3-game series with the Guardians on Wednesday with the 2nd game still to be played on Tuesday. The Yankees won the series opener on Tuesday. Their offense ranks 2nd in the MLB with a .764 OPS. Gerrit Cole is their starting pitcher on Tuesday while Carlos Rodón is making his start in this game on Wednesday. He is 1-2 with a 2.88 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 0 HR, and 3 BB with 7 SO on 2 hits through 6 IP against the Cleveland Guardians.

The Guardians are entering this series off a loss and lost their 3-game series against the Texas Rangers 2-1 in their last series. They enter this game with a 37-31 record overall and have a home record of 17-15. This is the 3rd game of a 3-game series with the Yankees on Wednesday with the 2nd game of this series still to be played on Tuesday. The Guardians lost the 1st game of this series on Monday. Their offense ranks 26th in the MLB with a .688 OPS. Slade Cecconi is their starting pitcher on Tuesday while Parker Messick is making his start in this game on Wednesday. He is 6-2 with a 2.40 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 2 homers, and 1 walk with 4 strikeouts on 5 hits through 5.2 innings pitched against the Texas Rangers.

The current betting odds have the Guardians listed as a slight favorite in this game according to Draftkings Sportsbook. The Yankees have looked great in their games this season with their 39-26 record overall which has them right near the top of the AL East. They have been a good road team too with their 20-14 road record this year. Meanwhile, the Guardians have looked great in their games this season with their 37-31 record overall which has them right at the top of the AL Central. They have looked good in their own ballpark too with their 17-15 home record this season. The Yankees are 6-4 in their last 10 games and have been getting hot again while the Guardians are 4-6 in their last 10 games, starting to slump after a hot streak. The Guardians did take 2 of their 3 games against the Yankees last week though and they have a great chance to take another game with this pitching matchup. The Guardians are going with Messick in this one and he has been a stud for them this season. He is 6-2 with a 2.40 ERA and he hasn't been giving up many runs at all. He did give up 3 earned runs in his last start and the team has lost 2 games in a row now with him starting, but that hasn't been a common theme for him this year and he is going to bounce back at home with another great start. The Yankees are going with Rodon in this one and he has looked good this season. He is 1-2 with a 2.88 ERA and he has looked a lot better lately. He is coming off a great start in which he gave up 1 earned run and the team has won 2 games in a row now with him starting, but he is still working his way back from an injury and didn't have the best start to the season. Rodon is still a shaky starter this season and the Yankees have been really up and down as a team lately too. The Guardians are going to bring their best effort for the Yankees just like they did last week, so look for the Guardians to take advantage of this pitching matchup with one of their best starters on the mound. The best way to place a bet here is on the Guardians to win this game. 

Yankees Guardians Prediction:  Our MLB Pick for Wednesday, June 10, 2026 (1:10 pm ET start time) is Guardians 2 Yankees 1.

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New York Yankees: 237-172 (-14.3 units) on the moneyline in all games. 55-49 (-20.5 units) on the moneyline against left-handed starters. 58-58 (-15.6 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 14-5 UNDER on the road when the money line is +125 to -125.

Cleveland Guardians: 222-182 (+36.8 units) on the moneyline in all games. 116-85 (+11.6 units) on the moneyline in home games. 129-77 (+23.4 units) on the moneyline as a favorite of -110 or higher. 60-43 UNDER vs. teams outscoring opp by 0.5 or more runs/game on the season.

New York Yankees:  A. Wells (C) Ten Day IL - Cervical Headaches. A. Judge (RF) Ten Day IL - Rib. M. Fried (SP) Fifteen Day IL - Elbow. J. Dominguez (LF) Ten Day IL - Shoulder. G. Stanton (DH) Ten Day IL - Leg. A. Chivilli (RP) Fifteen Day IL - Shoulder. C. Schmidt (SP) Sixty Day IL - Elbow.

Cleveland Guardians:  G. Arias (SS) Sixty Day IL - Hamstring. E. Sabrowski (RP) Fifteen Day IL - Elbow.

“Just a lot of really good things by guys in winning situations.” - Aaron Boone after his team’s win against the Guardians in their game on Monday. 

“Obviously they're a very good team. We're a very good team. That was a fun baseball game. Obviously, you wish you were on the winning side of it, but there was a lot of action in that game, a lot of good plays, a lot of good at-bats. But unfortunately, we didn't come out with the win.” - Stephen Vogt after his team’s loss against the Yankees in their game on Monday.

Trent Grisham (L) CF

Ben Rice (L) 1B

Paul Goldschmidt (R) DH

Cody Bellinger (L) LF

Jazz Chisholm Jr. (L) 2B

Spencer Jones (L) RF

José Caballero (R) SS

Ryan McMahon (L) 3B

J.C. Escarra (L) C

Travis Bazzana (L) 2B

José Ramírez (S) 3B

Chase DeLauter (L) DH

Kyle Manzardo (L) 1B

Daniel Schneemann (L) CF

Angel Martínez (S) RF

Steven Kwan (L) LF

Patrick Bailey (S) C

Brayan Rocchio (S) SS

Batting Average:  Ben Rice (.304)

Hits:  Ben Rice (66)

Home Runs:  Ben Rice (18)

RBI:  Ben Rice (45)

Stolen Bases:  Jazz Chisholm (16)

Wins:  Cam Schlittler (7)

Saves:  David Bednar (13)

ERA:  Yovanny Cruz (0.00)

Batting Average:  Brayan Rocchio (.284)

Hits:  José Ramírez (60)

Home Runs:  José Ramírez (10)

RBI:  Chase DeLauter (33)

Stolen Bases:  José Ramírez (23)

Wins:  Gavin Williams (9)

Saves:  Cade Smith (21)

ERA:  Logan Allen (0.00)

Managers:

New York Yankees: Aaron Boone (9th season)

Cleveland Guardians: Stephen Vogt (3rd season)