New York Yankees vs Boston Red Sox Prediction, Preview and Odds - 09/13/2025

Game Time: 4:10 pm ET, Saturday, September 13, 2025

Venue:  Fenway Park, Boston, MA

Where to Watch:  MLB Network

DraftKings:  Moneyline odds:  Yankees -132, Red Sox +108; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Yankees -130, Red Sox +110; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Yankees -130, Red Sox +110; Over/Under:  8.5 runs

New York Yankees:  81-65 (2nd place, AL East)

Boston Red Sox:  81-66 (3rd place, AL East)

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New York Yankees:  5-5 last 10

Boston Red Sox:  6-4 last 10

The Yankees are entering this series off a win and lost their 3-game series against the Detroit Tigers 2-1 in their last series. They enter this game with an 81-65 record overall and have a road record of 37-34. This is the 2nd game of a 3-game series with the Red Sox on Saturday with the series opener still to be played on Friday. Their offense ranks 1st in the MLB with a .785 OPS. Luis Gil is their starting pitcher on Friday while Max Fried is making his start in this game on Saturday. He is 16-5 with a 3.02 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 0 HR, and 1 BB with 4 SO on 6 hits through 7 IP against the Toronto Blue Jays.

The Red Sox are entering this series off a loss and won their 3-game series against the Athletics 2-1 in their last series. They enter this game with an 81-66 record overall and have a home record of 44-28. This is the 2nd game of a 3-game series with the Yankees on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 8th in the MLB with a .749 OPS. Lucas Giolito is their starting pitcher on Friday while Brayan Bello is making his start in this game on Saturday. He is 11-6 with a 3.12 ERA this season. His team won their last 5 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 0 homers, and 1 walk with 2 strikeouts on 4 hits through 6 innings pitched against the Arizona Diamondbacks.

The current betting odds have the Yankees listed as a slight favorite in this game according to Draftkings Sportsbook. The Red Sox have looked really good in their games this season with their 81-66 record overall which has them right in the middle of the AL East and in a Wild Card spot at the moment. They have also looked great in their own ballpark this year with their 44-28 home record. Meanwhile, the Yankees have looked really good in their games this season with their 81-65 record overall which has them right near the top of the AL East and in a Wild Card spot. They have been a good road team too with their 37-34 road record this year. The Yankees haven't been at their best lately as they are 5-5 in their last 10 games while the Red Sox are 6-4, but a 9-3 win over the Tigers to end that series should give them some momentum here. They are going to have Fried on the mound here and he has been their ace this season. He is 16-5 with a 3.02 ERA and the team has been having a ton of success with him all season. He did give up 3 earned runs in his last start, but that hasn't been a common theme for him this year, and the team has still won 3 games in a row with him starting. The Red Sox are going with Bello in this one and he has also looked good this season. He is 11-6 with a 3.12 ERA and his team has also been having a ton of success with him. He gave up 3 earned runs in his last start too and the team has won 5 games in a row now with him starting. Both teams need this series for the AL East race and both starters have been solid all year, but the Yankees do have the stronger offense along with the better bullpen and that gives them the edge in this tight game. The best way to place a bet here is on the Yankees to win this game. 

Yankees Red Sox Prediction:  Our MLB Pick for Saturday, September 13, 2025 (4:10 pm ET start time) is Yankees 4 Red Sox 3.

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New York Yankees: 264-219 (-28 units) on the moneyline in all games. 67-79 (-29.5 units) on the moneyline against division opponents. 75-73 (-8.2 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 26-15 UNDER on the road vs. AL teams scoring 4.9 or more runs/game on the season.

Boston Red Sox: 75-71 (+8.4 units) on the moneyline against division opponents. 49-45 (+6.2 units) on the moneyline vs. a starting pitcher who gives up 0.5 or less HR's/start. 81-86 (+5.8 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 15-4 UNDER at home when playing against a good team (Win Pct. 54% to 62%).

New York Yankees:  A. Volpe (SS) Day To Day - Shoulder. B. Headrick (RP) Fifteen Day IL - Forearm. J. Loaisiga (RP) Fifteen Day IL - Back. C. Schmidt (SP) Sixty Day IL - Forearm. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. G. Cole (SP) Sixty Day IL - Elbow.

Boston Red Sox:  V. Grissom (2B) Sixty Day IL - Foot. R. Gonzalez (1B) Day To Day - Knee. D. May (SP) Fifteen Day IL - Elbow. J. Hicks (RP) Fifteen Day IL - Shoulder. R. Anthony (RF) Ten Day IL - Oblique. M. Mayer (3B) Sixty Day IL - Wrist. R. Fitts (SP) Fifteen Day IL - Biceps. W. Abreu (RF) Ten Day IL - Calf. L. Guerrero (RP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Flexor. H. Dobbins (SP) Sixty Day IL - ACL. L. Hendriks (RP) Sixty Day IL - Hip. J. Winckowski (RP) Sixty Day IL - Elbow. T. Casas (1B) Sixty Day IL - Knee. K. Crawford (SP) Sixty Day IL - Knee. P. Sandoval (SP) Sixty Day IL - Elbow.

“He had a partial labrum tear that I think they felt like was an old injury. Really, it was more just aggravating it and the swelling of it. Once that got out of there, it was good to go. He’s aggravated it a couple of times, Sunday being one of them.” - Aaron Boone on the injury to Anthony Volpe. 

“He did a good job -- good fastball and good command, great tempo. That was good to see. He was very patient throughout the process, and for him to go out there and give us a chance to win, that was awesome.” - Alex Cora after his team’s loss against the A’s in their game on Wednesday.

Austin Slater (R) LF

Aaron Judge (R) RF

Cody Bellinger (L) CF

Giancarlo Stanton (R) DH

Jazz Chisholm Jr. (L) 2B

Paul Goldschmidt (R) 1B

Ben Rice (L) C

José Caballero (R) SS

Ryan McMahon (L) 3B

Jarren Duran (L) LF

Alex Bregman (R) 3B

Trevor Story (R) SS

Nathaniel Lowe (L) 1B

Masataka Yoshida (L) DH

Carlos Narváez (R) C

David Hamilton (L) 2B

Nate Eaton (R) RF

Ceddanne Rafaela (R) CF

Batting Average:  Amed Rosario (.400)

Hits:  Aaron Judge (158)

Home Runs:  Aaron Judge (46)

RBI:  Aaron Judge (100)

Stolen Bases:  Jazz Chisholm (28)

Wins:  Carlos Rodón (16)

Saves:  Devin Williams (18)

ERA:  Adam Ottavino (0.00)

Batting Average:  Romy Gonzalez (.311)

Hits:  Jarren Duran (146)

Home Runs:  Trevor Story (24)

RBI:  Trevor Story (91)

Stolen Bases:  Trevor Story (28)

Wins:  Garrett Crochet (15)

Saves:  Aroldis Chapman (29)

ERA:  Nick Burdi (0.00)

Managers:

New York Yankees: Aaron Boone (8th season)

Boston Red Sox: Álex Cora (5th season)