New York Giants vs Washington Commanders Prediction, Preview and Odds - 09/07/2025

Game Time: 1:00 pm ET, Sunday, September 7, 2025

Venue:  Northwest Stadium, Landover, MD

Where to Watch:  FOX

DraftKings:  Point Spread:  Giants +6, Commanders -6; Over/Under:  45.5 points

Bet365:  Point Spread:  Giants +6, Commanders -6; Over/Under:  45.5 points

BetMGM:  Point Spread:  Giants +6, Commanders -6; Over/Under:  45.5 points

New York Giants:  0-0 (NFC East)

Washington Commanders:  0-0 (NFC East)

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New York Giants:  N/A

Washington Commanders:  N/A

The Giants finished last season with a 3-14 record overall and they were 0-6 in their division games too. They had a 1-8 record in their home games and had a 2-6 record in their road games where they will be in this game. Last season, their offense was averaging 16.1 points per game and their defense was allowing an average of 24.4 points per game. Their offense was also averaging 294.8 yards per game and their defense was allowing an average of 346.8 yards per game. Daniel Jones led the team in passing yards with 2,070, Tyrone Tracy Jr. led the team in rushing yards with 839, and Malik Nabers led the team in receiving yards with 1,204.

The Commanders finished last season with a 12-5 record overall and they were 4-2 in their division games too. They had a 7-2 record in their home games and had a 5-3 record in their road games where they will be in this game. Last season, their offense was averaging 28.5 points per game and their defense was allowing an average of 23 points per game. Their offense was also averaging 369.6 yards per game and their defense was allowing an average of 326.9 yards per game. Jayden Daniels led the team in passing yards with 3,568, Jayden Daniels led the team in rushing yards with 891, and Terry McLaurin led the team in receiving yards with 1,096.

The current betting odds have the Commanders listed as a 6 point favorite in this game according to Draftkings Sportsbook. The Commanders had a great season last year, finishing 12-5 overall and made a deep run in the playoffs. They came up short in the end, but that was a great first season for their new head coach and rookie quarterback. Now the team will be looking to build off that great first year and they have added some talent to the offense to help Jayden Daniels grow in his 2nd NFL season. The defense wasn't great last season, but they should improve this year with Dan Quinn now in his 2nd season. Meanwhile, the Giants looked terrible last season as they finished 3-14 overall and were one of the worst teams in the NFL. They have picked up a lot of young talent from the draft the last 2 seasons and are well on their way to improving, but this is still a team that is going to have a lot of growing pains, especially with their head coach on the hot seat. They still have a lot of question marks at QB too with Russell Wilson getting the start in this one. Wilson hasn't shown that there is much left in the tank over the last few seasons so even if this Commanders defense isn't up to par, this Giants offense will still struggle to move the ball. The Commanders have the talent on offense to pull away throughout this game and will be looking to have a strong start to the season after the great year they had. The best way to place a bet here is on the Commanders to cover the spread in this game. 

Giants Commanders Prediction:  Our NFL Pick for Sunday, September 7, 2025 (1:00 pm ET start time) is Commanders 31 Giants 17.

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New York Giants: 72-49 ATS in a road game where the total is between 42.5 and 49 points. 9-5 1H OVER in all games where the total is between 42.5 and 49 points. 8-4 1H OVER versus division opponents. 

Washington Commanders: 4-8 ATS versus division opponents. 39-63 ATS as a favorite of 3.5 to 9.5 points. 23-14 OVER in all games. 16-8 OVER in all games where the total is between 42.5 and 49 points. 

New York Giants:  None.

Washington Commanders:  None.

"I think just the effort of the guys is what we're really focused on, the discipline, their team-first attitude, their work ethic, big things, accountability to one another, to the coaches, to the players. It's a process of training camp to the preseason games, and being able to execute regardless of who is in there. There is a standard that I'm going to hold everybody to, and we got 17 days here before the first one, so we've got a lot of work to still get done." - Brian Daboll on his team coming into this new NFL season.

“I don't know if emerging, but we were pretty confident going into the camp what we'd see and how we'd go. And so, when the opportunity with [General Manager] Adam [Peters] and team to go that way, that seemed to make the most sense and from a fit and the whole thing forward, so it made sense.” - Dan Quinn on the team trading away Brian Robinson Jr.

WR Nabers, Malik

WR Slayton, Darius

WR Robinson, Wan'Dale

TE Johnson, Theo

QB Wilson, Russell

RB Tracy Jr., Tyrone

WR McLaurin, Terry

WR Brown, Noah

WR Samuel, Deebo

TE Ertz, Zach

QB Daniels, Jayden

RB Ekeler, Austin

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Coaches:

New York Giants: Brian Daboll (4th season)

Washington Commanders: Dan Quinn (2nd season)