by Rod Pearson
Tuesday, Sep 30, 2025
Game Time: 1:00 pm ET, Sunday, October 5, 2025
Venue: Caesars Superdome, New Orleans, LA
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Giants +1.5, Saints -1.5; Over/Under: 40.5 points
Bet365: Point Spread: Giants +1.5, Saints -1.5; Over/Under: 41 points
BetMGM: Point Spread: Giants +1.5, Saints -1.5; Over/Under: 40.5 points
Season Record
New York Giants: 1-3 (4th place, NFC East)
New Orleans Saints: 0-4 (4th place, NFC South)
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Recent Form
New York Giants: won their last game at home against the Los Angeles Chargers 21-18.
New Orleans Saints: lost their last game on the road against the Buffalo Bills 31-19.
New York Giants vs New Orleans Saints Preview and Analysis
The Giants are entering this game with a 1-3 record overall and they have a 0-2 record in their divisional games too. They are 1-1 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Los Angeles Chargers 21-18. Jaxson Dart was the starting QB and he completed 13/20 passes for 111 passing yards, 1 touchdown, and 0 interceptions. Cameron Skattebo led the team in rushing yards with 79. Darius Slayton led the receivers with 44 receiving yards on 3 receptions. Cor'Dale Flott led the defense in that game with 5 solo tackles and 0 assisted tackles while Brian Burns and Kayvon Thibodeaux each led the defense in sacks with 1. Andru Phillips and Dexter Lawrence II each came away with 1 interception for them in that one.
The Saints are entering this game with a 0-4 record overall and they have a 0-0 record in their divisional games too. They are 0-2 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Buffalo Bills 31-19. Spencer Rattler was the starting QB and he completed 18/27 passes for 126 passing yards, 1 touchdown, and 0 interceptions. Alvin Kamara led the team in rushing yards with 70. Rashid Shaheed led the receivers with 47 receiving yards on 4 receptions. Kool-Aid McKinstry led the defense in that game with 7 solo tackles and 0 assisted tackles while Carl Granderson, Cameron Jordan, and Bryan Bresee each led the defense in sacks with 1. Jonas Sanker came away with the only interception for them in that one.
Giants vs Saints Prediction
The current betting odds have the Giants listed as a 1.5 point underdog in this game according to Draftkings Sportsbook. The Giants have looked terrible in their games this season with their 1-3 record overall which has them right near the bottom of the NFC East, but they looked a lot better in their last game. They made a change at QB, going with their rookie Jaxson Dart, and they pulled off their first win of the season last week over a very good Chargers team. The defense looked a lot better in that one too and now the Giants are going to have a ton of momentum coming into this game against one of the worst teams in the NFL. Meanwhile, the Saints have looked terrible in their games this season with their 0-4 record overall which has them right at the bottom of the NFC South with one of the few winless records left in the NFL. They are off a 31-19 loss to the Bills in their last one and they have pretty much struggled in every game this season. Their defense hasn't looked great and their offense hasn't looked great either with Spencer Rattler leading the way. The Giants are in a much better situation here off their first win and they have all the momentum on their side coming into this one. The best way to place a bet here is on the Giants to cover the spread in this game.
Giants Saints Prediction: Our NFL Pick for Sunday, October 5, 2025 (1:00 pm ET start time) is Giants 20 Saints 13.
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NFL Betting Trends
New York Giants: 26-16 ATS in dome games. 28-15 ATS on the road after a win by 6 or less points. 50-29 ATS versus poor defensive teams - allowing 5.65 yards/play or more. 9-0 UNDER in games where the line is +3 to -3. 6-1 UNDER off an upset win as an underdog.
New Orleans Saints: 14-23 ATS in all games. 6-11 ATS in games where the line is +3 to -3. 5-12 ATS after playing their last game on the road. 13-7 UNDER in all games where the total is between 35.5 and 42 points. 5-1 UNDER when playing against a bad team (Win Pct. 25% to 40%).
Key Injuries
New York Giants: D. Lawrence II (DL) Injured - Illness. T. Nubin (S) Injured - Groin. T. Tracy Jr. (RB) Injured - Shoulder. G. Van Roten (OG) Injured - NIR-Rest. D. Belton (S) Injured - Shoulder. D. Davidson (DL) Injured - Foot. C. Golston (DL) Injured - NIR-Rest. J. Holland (S) Injured - Ankle. J. Schmitz Jr. (C) Injured - Ankle. R. Nunez-Roches Sr. (DL) Injured - Foot. J. Dart (QB) Injured - Hamstring. C. Skattebo (RB) Injured - Knee. R. Wilson (QB) Injured - Ankle.
New Orleans Saints: D. Radunz (OG) Injured - Toe. C. Ruiz (OG) Injured - Ankle. C. Young (DL) Injured - Calf. T. Hill (TE) Injured - Knee. F. Moreau (TE) Injured - Knee. T. Palmer (WR) Injured - Ankle. J. Reid (S) Injured - Knee. J. Ridgeway III (DL) Injured - Shoulder. I. Yiadom (CB) Injured - Hamstring. J. Johnson (TE) Injured - Ankle. T. Penning (OG) Injured - Ankle.
Notable Quotes
“I know (No.) 6 is probably going to be sore. I mean, he gutted it out. Son’s a tough son of a you know what. He’s tough, but I knew that.” - Brian Daboll after his team’s win against the LA Chargers in their last game.
“We put ourselves in position. I felt like we were competing. We were playing the right way. We just came up short. We didn’t make enough plays when it mattered most.” - Kellen Moore after his team’s loss against the Bills in their last game.
Starting Lineups
New York Giants
WR Hyatt, Jalin
WR Slayton, Darius
WR Robinson, Wan'Dale
TE Johnson, Theo
QB Dart, Jaxson
RB Skattebo, Cam
New Orleans Saints
WR Olave, Chris
WR Cooks, Brandin
WR Shaheed, Rashid
TE Johnson, Juwan
QB Rattler, Spencer
RB Kamara, Alvin
Statistical Leaders
New York Giants
Passing: Russell Wilson (786)
Rushing: Cam Skattebo (181)
Receiving: Malik Nabers (271)
Touchdowns: Malik Nabers (2)
New Orleans Saints
Passing: Spencer Rattler (765)
Rushing: Alvin Kamara (256)
Receiving: Juwan Johnson (204)
Touchdowns: Alvin Kamara (1)
Coaches:
New York Giants: Brian Daboll (4th season)
New Orleans Saints: Kellen Moore (1st season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
