by Rod Pearson
Friday, Sep 19, 2025
Game Time: 4:05 pm ET, Sunday, September 21, 2025
Venue: Lumen Field, Seattle, WA
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Saints +7.5, Seahawks -7.5; Over/Under: 41.5 points
Bet365: Point Spread: Saints +7.5, Seahawks -7.5; Over/Under: 41.5 points
BetMGM: Point Spread: Saints +7.5, Seahawks -7.5; Over/Under: 41.5 points
Season Record
New Orleans Saints: 0-2 (3rd place, NFC South)
Seattle Seahawks: 1-1 (4th place, NFC West)
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Recent Form
New Orleans Saints: lost their last game at home against the San Francisco 49ers 26-21.
Seattle Seahawks: won their last game on the road against the Pittsburgh Steelers 31-17.
New Orleans Saints vs Seattle Seahawks Preview and Analysis
The Saints are entering this game with a 0-2 record overall and they have a 0-0 record in their divisional games too. They are 0-2 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the San Francisco 49ers 26-21. Spencer Rattler was the starting QB and he completed 25/34 passes for 207 passing yards, 3 touchdowns, and 0 interceptions. Alvin Kamara led the team in rushing yards with 99. Chris Olave led the receivers with 54 receiving yards on 6 receptions. Isaac Yiadom led the defense in that game with 6 solo tackles and 1 assisted tackle while Carl Granderson led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.
The Seahawks are entering this game with a 1-1 record overall and they have a 0-1 record in their divisional games too. They are 0-1 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Pittsburgh Steelers 31-17. Sam Darnold was the starting QB and he completed 22/33 passes for 295 passing yards, 2 touchdowns, and 2 interceptions. Kenneth Walker III led the team in rushing yards with 105 and 1 TD. Jaxon Smith-Njigba led the receivers with 103 receiving yards on 8 receptions. Ernest Jones IV led the defense in that game with 8 solo tackles and 2 assisted tackles while Byron Murphy II led the defense in sacks with 1.5. Coby Bryant and Derion Kendrick each came away with 1 interception for them in that one.
Saints vs Seahawks Prediction
The current betting odds have the Saints listed as a 7.5 point underdog in this game according to Draftkings Sportsbook. The Saints haven't looked great in their games this season with their 0-2 record overall and they have one of the worst teams in the NFL this season, but they haven't played like it yet. They lost to the Cardinals and the 49ers in their 2 games, but neither of those are bad teams and they managed to stay competitive in both games. They haven't lost by over 7 points in either game and their offense looked a lot better against the 49ers last week who do have a good defense. Meanwhile, the Seahawks have a 1-1 record overall and haven't looked great in their 2 games. They just beat the Steelers on the road 31-17, but they lost their only home game to the 49ers 17-13 and their offense hasn't looked great with Sam Darnold. Their defense has looked great in both games so the Saints aren't going to have an easy game on offense here, but the Saints defense hasn't been that bad either. The Saints defense will keep this a manageable game for them and the Seahawks won't be able to pull away too much with that struggling offense. The best way to place a bet here is on the Saints to cover the spread in this game.
Saints Seahawks Prediction: Our NFL Pick for Sunday, September 21, 2025 (4:05 pm ET start time) is Seahawks 20 Saints 16.
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NFL Betting Trends
New Orleans Saints: 0-4 ATS against NFC West division opponents. 13-22 ATS in all games. 6-12 ATS in all games where the total is between 35.5 and 42 points. 7-1 UNDER in a road game where the total is between 35.5 and 42 points. 5-1 UNDER after a loss by 6 or less points.
Seattle Seahawks: 2-0 ATS against NFC South division opponents. 34-23 ATS at home after scoring 30 points or more last game. 36-27 ATS at home in the first month of the season. 4-1 UNDER after scoring 30 points or more last game.
Key Injuries
New Orleans Saints: D. Vele (WR) Injured - Hip. T. Penning (OG) Injured - Toe. T. Fuaga (OT) Injured - Knee. D. Radunz (OG) Injured - Toe. C. Young (DL) Injured - Calf. T. Palmer (WR) Injured - Hamstring.
Seattle Seahawks: Z. Charbonnet (RB) Injured - Foot. N. Emmanwori (S) Injured - Ankle. D. Hall (LB) Injured - Hip. T. Horton (WR) Injured - Groin. J. Jobe (CB) Injured - Knee. E. Jones IV (LB) Injured - Shoulder. J. Love (S) Injured - Hamstring. A. Lucas (OT) Injured - Elbow. D. Witherspoon (CB) Injured - Knee.
Notable Quotes
“We have a great group (of) guys that play their tail off. But we have to play cleaner football and do what winning teams do in each and every moment.” - Kellen Moore after his team’s loss against the 49ers in their last game.
“We got a couple breaks there in the second half that went our way and we took advantage of it.” - Mike Macdonald after his team’s win against the Steelers in their last game.
Starting Lineups
New Orleans Saints
WR Olave, Chris
WR Cooks, Brandin
WR Shaheed, Rashid
TE Johnson, Juwan
QB Rattler, Spencer
RB Kamara, Alvin
Seattle Seahawks
WR Horton, Tory
WR Smith-Njigba, Jaxon
WR Kupp, Cooper
TE Barner, AJ
QB Darnold, Sam
RB Walker III, Kenneth
FB Ouzts, Robbie
Statistical Leaders
New Orleans Saints
Passing: S. Rattler (421)
Rushing: A. Kamara (144)
Receiving: J. Johnson (125)
Touchdowns: A. Kamara (1)
Seattle Seahawks
Passing: S. Darnold (445)
Rushing: K. Walker III (125)
Receiving: J. Smith-Njigba (227)
Touchdowns: Z. Charbonnet (1)
Coaches:
New Orleans Saints: Kellen Moore (1st season)
Seattle Seahawks: Mike Macdonald (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
