by Rod Pearson
Thursday, Nov 06, 2025
Game Time: 1:00 pm ET, Sunday, November 9, 2025
Venue: Bank of America Stadium, Charlotte, NC
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Saints +5.5, Panthers -5.5; Over/Under: 39.5 points
Bet365: Point Spread: Saints +5.5, Panthers -5.5; Over/Under: 39.5 points
BetMGM: Point Spread: Saints +5.5, Panthers -5.5; Over/Under: 39.5 points
Season Record
New Orleans Saints: 1-8 (4th place, NFC South)
Carolina Panthers: 5-4 (2nd place, NFC South)
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New Orleans Saints: lost their last game on the road against the Los Angeles Rams 34-10.
Carolina Panthers: won their last game on the road against the Green Bay Packers 16-13.
New Orleans Saints vs Carolina Panthers Preview and Analysis
The Saints are entering this game with a 1-8 record overall and they have a 0-1 record in their divisional games too. They are 1-4 in their home games, 0-4 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Los Angeles Rams 34-10. Tyler Shough was the starting QB and he completed 15/24 passes for 176 passing yards, 1 touchdown, and 1 interception. Taysom Hill led the team in rushing yards with 30. Rashid Shaheed led the receivers with 68 receiving yards on 5 receptions. Justin Reid led the defense in that game with 7 solo tackles and 6 assisted tackles while Chase Young and Jonah Williams each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Panthers are entering this game with a 5-4 record overall and they have a 1-0 record in their divisional games too. They are 3-1 in their home games, 2-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Green Bay Packers 16-13. Bryce Young was the starting QB and he completed 11/20 passes for 102 passing yards, 0 touchdowns, and 1 interception. Rico Dowdle led the team in rushing yards with 130 and 2 TDs. Tetairoa McMillan led the receivers with 46 receiving yards on 4 receptions. Christian Rozeboom led the defense in that game with 7 solo tackles and 8 assisted tackles while Tershawn Wharton led the defense in sacks with 1. Tre'von Moehrig came away with the only interception for them in that one.
Saints vs Panthers Prediction
The current betting odds have the Panthers listed as a 5.5 point favorite in this game according to Draftkings Sportsbook. The Panthers have looked good in their games this season with their 5-4 record overall which has them right near the top of the NFC South. They are off a big upset win over the Packers on the road, winning 16-13, and they have looked a lot better on their home field this year with their 3-1 home record. Meanwhile, the Saints have looked terrible in their games this season with their 1-8 record overall which has them right at the bottom of the NFC South with one of the worst records in the entire NFL. They recently made a QB change to Tyler Shough, but that didn't help much in their last one as they are off a 34-10 loss to the Rams. Their only win this year also came at home so they have been a really bad road team with their 0-4 road record. The Panthers aren't a great team, but they have looked a lot better lately and are finding ways to win games. Bryce Young is playing a lot better in this offense and their run game has been really tough to stop. Even their defense has looked a lot better lately as they haven't been giving up as many points so this is going to be another road game where the Saints offense struggles. These teams are headed in 2 different directions right now and the Panthers can take advantage of that. The best way to place a bet here is on the Panthers to cover the spread in this game.
Saints Panthers Prediction: Our NFL Pick for Sunday, November 9, 2025 (1:00 pm ET start time) is Panthers 27 Saints 13.
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NFL Betting Trends
New Orleans Saints: 15-27 ATS in all games. 3-10 ATS as an underdog of 3.5 to 9.5 points. 5-11 ATS when playing against a team with a winning record. 26-17 UNDER in all games. 7-2 UNDER off 3 or more consecutive unders. 13-6 UNDER after playing their last game on the road.
Carolina Panthers: 30-22 ATS off an upset win as a road underdog. 33-23 ATS vs. poor passing teams averaging 5.7 or less passing yards/att. 38-15 ATS vs. poor offensive teams - scoring 17 or less points/game. 5-1 UNDER versus division opponents.
Key Injuries
New Orleans Saints: C. Jordan (DL) Injured - Ankle. A. Kamara (RB) Injured - Ankle. T. Hill (TE) Injured - Knee. B. Wesley (OT) Injured - Hip. J. Stoll (TE) Injured - Ankle. J. Williams (DL) Injured - Shoulder. T. Fuaga (OT) Injured - Ankle.
Carolina Panthers: R. Dowdle (RB) Injured - Quadriceps. C. Mays (C) Injured - Ankle. D. Lewis (OG) Injured - Oblique. C. Zavala (OG) Injured - Elbow. L. Ransom (S) Injured - Illness. P. Umanmielen (LB) Injured - Ankle.
Notable Quotes
“We didn’t give ourselves a chance in this one. It’s frustrating. They really controlled the game in so many ways, so we didn’t get enough shots at it.” - Kellen Moore after his team’s loss against the LA Rams in their last game.
“From carry one, it was attitude, it was aggression and violence at the end of it. It really does affect the group. It affects the whole sideline when they see that kind of energy. That kind of violence, it gives them confidence. It's who we want to be.” - Dave Canales after his team’s win against the Packers in their last game.
Starting Lineups
New Orleans Saints
WR Olave, Chris
WR Cooks, Brandin
WR Vele, Devaughn
TE Johnson, Juwan
QB Shough, Tyler
RB Kamara, Alvin
Carolina Panthers
WR McMillan, Tetairoa
WR Legette, Xavier
WR Coker, Jalen
TE Sanders, Ja'Tavion
QB Young, Bryce
RB Dowdle, Rico
Statistical Leaders
New Orleans Saints
Passing: Spencer Rattler (1,586)
Rushing: Alvin Kamara (377)
Receiving: Chris Olave (560)
Touchdowns: Chris Olave (3)
Carolina Panthers
Passing: Bryce Young (1,390)
Rushing: Rico Dowdle (735)
Receiving: Tetairoa McMillan (558)
Touchdowns: Rico Dowdle (5)
Coaches:
New Orleans Saints: Kellen Moore (1st season)
Carolina Panthers: Dave Canales (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
