by Rod Pearson
Tuesday, Oct 14, 2025
Game Time: 1:00 pm ET, Sunday, October 19, 2025
Venue: Nissan Stadium, Nashville, TN
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Patriots -7, Titans +7; Over/Under: 42.5 points
Bet365: Point Spread: Patriots -7, Titans +7; Over/Under: 42 points
BetMGM: Point Spread: Patriots -7, Titans +7; Over/Under: 42.5 points
Season Record
New England Patriots: 4-2 (1st place, AFC East)
Tennessee Titans: 1-5 (4th place, AFC South)
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New England Patriots: won their last game on the road against the New Orleans Saints 25-19.
Tennessee Titans: lost their last game on the road against the Las Vegas Raiders 20-10.
New England Patriots vs Tennessee Titans Preview and Analysis
The Patriots are entering this game with a 4-2 record overall and they have a 2-0 record in their divisional games too. They are 1-2 in their home games, 3-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the New Orleans Saints 25-19. Drake Maye was the starting QB and he completed 18/26 passes for 261 passing yards, 3 touchdowns, and 0 interceptions. Drake Maye led the team in rushing yards with 28. Kayshon Boutte led the receivers with 93 receiving yards on 5 receptions and 2 TDs. Robert Spillane led the defense in that game with 5 solo tackles and 6 assisted tackles while Marcus Jones and Harold Landry III each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Titans are entering this game with a 1-5 record overall and they have a 0-2 record in their divisional games too. They are 0-2 in their home games, 1-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Las Vegas Raiders 20-10. Cameron Ward was the starting QB and he completed 26/38 passes for 222 passing yards, 1 touchdown, and 1 interception. Tony Pollard led the team in rushing yards with 34. Van Jefferson led the receivers with 75 receiving yards on 4 receptions. L'Jarius Sneed led the defense in that game with 6 solo tackles and 4 assisted tackles while Jeffery Simmons and Dre'Mont Jones each led the defense in sacks with 1. Cody Barton came away with the only interception for them in that one.
Patriots vs Titans Prediction
The current betting odds have the Patriots listed as a 7 point favorite in this game according to Draftkings Sportsbook. The Patriots have looked really good in their games this season with their 4-2 record overall which has them right at the top of the AFC East. Drake Maye has looked great this season and this offense has been getting better each week. They still don't have a great defense, but they have looked a lot better in their last 2 games, not giving up as many points. This is also a big game for their head coach Mike Vrabel who is returning to the place where he coached 6 seasons over the last decade. Meanwhile, the Titans have looked terrible in their games this season with their 1-5 record overall which has them right at the bottom of the AFC South with one of the worst records in the entire NFL. They were the worst team in the NFL last season, but they haven't improved much this season and they are going to be one of the worst teams in the NFL once again. They also just fired their head coach so this team is a disaster coming into this one. The defense hasn't looked great this season and the offense has looked terrible, struggling to put up points in their games. The Patriots are a team that is on the rise right now and they aren't going to let one of the worst teams in the league trip them up here. The best way to place a bet here is on the Patriots to cover the spread in this game.
Patriots Titans Prediction: Our NFL Pick for Sunday, October 19, 2025 (1:00 pm ET start time) is Patriots 35 Titans 13.
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NFL Betting Trends
New England Patriots: 34-25 ATS against AFC South division opponents. 22-15 ATS on the road vs. poor passing teams averaging 5.7 or less passing yards/att. 39-27 ATS on the road vs. bad defensive teams who give up 24 or more points/game. 7-1 UNDER as a favorite. 7-1 UNDER vs. poor teams - outscored by 6+ points per game on the season.
Tennessee Titans: 11-28 ATS in all games. 4-16 ATS as an underdog of 3.5 to 9.5 points. 5-14 ATS after playing their last game on the road. 9-1 UNDER vs. poor passing defenses - allowing 7 or more passing yards/att. 9-5 UNDER vs. poor passing defenses - allowing 235 or more passing yards/game.
Key Injuries
New England Patriots: S. Diggs (WR) Injured - Chest. M. Moses (OT) Injured - Hip. A. Jennings (LB) Injured - Ankle. H. Landry III (LB) Injured - Ankle. J. Hawkins (S) Injured - Hamstring. K. White (DL) Injured - Elbow. C. Barmore (DL) Injured - NIR - Other. C. Gonzalez (CB) Injured - Hamstring. C. Woods (CB) Injured - Knee.
Tennessee Titans: K. Zeitler (OG) Injured - NIR-Rest. B. Hance (OG) Injured - Shoulder. M. Harris (CB) Injured - Calf. V. Jefferson (WR) Injured - Ankle. A. Key (LB) Injured - Quadricep. T. Lockett (WR) Injured - NIR-Rest. J. Lynch (DL) Injured - Shoulder. B. Oliver (WR) Injured - Knee. C. Ridley (WR) Injured - Hamstring. J. Simmons (DL) Injured - NIR-Rest. J. Slye (K) Injured - Calf. L. Sneed (CB) Injured - Quadricep. T. Sweat (DL) Injured - Ankle. K. Winston Jr. (S) Injured - Hamstring.
Notable Quotes
“We will never not enjoy and embrace winning in this league, but I do think guys are aware of the fact that it can be better. To do that on the road and be able to end it with the ball offensively in victory formation is fun.” - Mike Vrabel after his team’s win against the Saints in their last game.
“They did a good job mixing up some coverages. They pressured a lot more this game than they had going into it. They zero blitzed us (with no deep safety) a few times, which is not something they had done a lot of.” - Brian Callahan after the Titans loss against the Raiders in their last game.
Starting Lineups
New England Patriots
WR Boutte, Kayshon
WR Hollins, Mack
WR Diggs, Stefon
TE Henry, Hunter
QB Maye, Drake
RB Stevenson, Rhamondre
FB Westover, Jack
Tennessee Titans
WR Ayomanor, Elic
WR Jefferson, Van
WR Dike, Chimere
TE Okonkwo, Chig
QB Ward, Cam
RB Pollard, Tony
Statistical Leaders
New England Patriots
Passing: Drake Maye (1,522)
Rushing: Rhamondre Stevenson (157)
Receiving: Stefon Diggs (387)
Touchdowns: Hunter Henry (3)
Tennessee Titans
Passing: Cam Ward (1,101)
Rushing: Tony Pollard (362)
Receiving: Calvin Ridley (290)
Touchdowns: Elic Ayomanor (2)
Coaches:
New England Patriots: Mike Vrabel (1st season)
Tennessee Titans: Mike McCoy (Interim)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
