Missouri Tigers vs Vanderbilt Commodores Prediction, Picks and Game Preview - 10/25/2025

Game Time: 3:30 pm ET, Saturday, October 25, 2025

Venue:  FirstBank Stadium, Nashville, TN

Where to Watch:  ESPN

DraftKings:  Point Spread:  Mizzou +2.5, Vandy -2.5; Over/Under:  52.5 points

Bet365:  Point Spread:  Mizzou +2.5, Vandy -2.5; Over/Under:  52.5 points

BetMGM:  Point Spread:  Mizzou +2.5, Vandy -2.5; Over/Under:  52.5 points

Missouri Tigers:  6-1 (2-1) (6th place, SEC)

Vanderbilt Commodores:  6-1 (2-1) (5th place, SEC)

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Missouri Tigers:  won their last game on the road against the Auburn Tigers 23-17 in overtime.

Vanderbilt Commodores:  won their last game at home against the LSU Tigers 31-24.

Missouri is entering this game with a 6-1 record overall and they have a 2-1 record in their conference games too. They are 5-1 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Auburn 23-17 in OT. Beau Pribula was the starting QB and he completed 23/40 passes for 252 passing yards, 0 touchdowns, and 2 interceptions. Ahmad Hardy led the team in rushing yards with 58 and 2 TDs. Donovan Olugbode led the receivers with 69 receiving yards on 5 receptions. Josiah Trotter led the defense in that game with 7 solo tackles and 1 assisted tackle while Zion Young led the defense in sacks with 2. Toriano Pride Jr. came away with the only interception for them in that one.

 

 

 

Vanderbilt is entering this game with a 6-1 record overall and they have a 2-1 record in their conference games too. They are 4-0 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against LSU 31-24. Diego Pavia was the starting QB and he completed 14/22 passes for 160 passing yards, 1 touchdown, and 0 interceptions. Diego Pavia led the team in rushing yards with 86 and 2 TDs. Cole Spence led the receivers with 56 receiving yards on 5 receptions and 1 TD. Langston Patterson led the defense in that game with 5 solo tackles and 0 assisted tackles while Zaylin Wood and Keanu Koht each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Vanderbilt listed as a 2.5 point favorite in this game according to Draftkings Sportsbook. Vanderbilt has looked really good in their games this season with their 6-1 record overall and their 2-1 conference record which has them right near the top of the SEC. They are ranked inside the top 25 at the moment and they have been rolling in their home games this season with their 4-0 home record. They are off a 31-24 win over LSU in their last one, putting up 31 points on a really good defense, and they have a real shot at the conference with the way they have been playing this year. Meanwhile, Missouri has looked really good in their games this season with their 6-1 record overall and their 2-1 conference record which has them right near the top of the SEC. They were rolling to start the season with their offense putting up a ton of points, but their defense has been an issue. They have been giving up a lot of points all year and now that their conference schedule has started, their offense hasn't looked as good lately. They struggled at home in their 27-24 loss to Alabama and they managed to bounce back in their last one, but they barely beat a terrible Auburn team in OT. They struggled a lot against one of the worst teams in the SEC this year, and that is also the only road game they have played all season. This is going to be a much tougher road game for them against a better team and Vanderbilt has so much momentum on their side right now with how good they have looked at home. The best way to place a bet here is on Vanderbilt to cover the spread in this game. 

Missouri Vanderbilt Prediction:  Our NCAAF Pick for Saturday, October 25, 2025 (3:30 pm ET start time) is Vanderbilt 34 Missouri 27.

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Missouri Tigers: 23-10 ATS in all lined games. 6-1 ATS when the line is +3 to -3. 8-1 ATS after playing their last game on the road. 8-3 ATS vs. good offensive  teams - scoring 31 or more points/game. 5-1 OVER after a win by 6 or less points. 9-5 OVER when playing against a team with a winning record.

Vanderbilt Commodores: 19-30 ATS at home versus good rushing defenses - allowing 120 rushing yards/game or less. 16-25 ATS at home versus good rushing defenses - allowing 3.25 rushing yards/carry or less. 19-26 ATS at home vs. good teams - outscoring opponents by 10+ PPG on the season. 10-2 OVER when the total is between 49.5 and 56. 8-2 OVER when playing against a top-level team (Win Pct. > 75%).

Missouri Tigers:  L. Reichert (OG) Questionable - Undisclosed. S. Horn (QB) Out - Leg. B. Craig (K) Out - Undisclosed.

Vanderbilt Commodores:  V. Hinton (CB) Questionable - Undisclosed. B. Lipford (S) Questionable - Undisclosed. N. Jefferson (DL) Questionable - Undisclosed. J. Curtis (LB) Questionable - Undisclosed. Y. Ouattara (DL) Questionable - Undisclosed. C. Gillespie (RB) Questionable - Undisclosed. D. Dickey (QB) Questionable - Undisclosed.

“We talked all week about how the game was played between the lines, not to let the exterior factors of the noise and the stadium affect us. The guys did a great job, and I just thought there was a refusal to lose.” - Eli Drinkwitz after his team’s win against Auburn in their last game. 

“Ultimately we have a lot of season left, and we’re going to celebrate this win. I think we’ve earned the right to celebrate it. But this game won’t define our season. And there’s a lot more for this team to accomplish.” - Clark Lea after his team’s win against LSU in their last game. 

WR Johnson, Marquis

WR Manning, Joshua

WR Coleman Jr., Kevin

TE Norfleet, Brett

QB Pribula, Beau

RB Hardy, Ahmad

WR Sherrill, Junior

WR Richardson, Tre

WR Hoskins, Richie

TE Stowers, Eli

QB Pavia, Diego

RB Alexander, Sedrick

Passing: Beau Pribula (1,617)

Rushing: Ahmad Hardy (840)

Receiving: Kevin Coleman Jr. (449)

Touchdowns: Ahmad Hardy (11)

Passing: Diego Pavia (1,569)

Rushing: Diego Pavia (438)

Receiving: Eli Stowers (355)

Touchdowns: Sedrick Alexander (10)

Coaches:

Missouri Tigers: Eli Drinkwitz (6th season)

Vanderbilt Commodores: Clark Lea (5th season)