Missouri Tigers vs Kansas Jayhawks Prediction, Picks and Game Preview - 09/11/2026

Game Time: 8:00 pm ET, Friday, September 11, 2026

Venue:  David Booth Kansas Memorial Stadium, Lawrence, KS

Where to Watch:  FOX

DraftKings:  Point Spread:  Mizzou -5.5, Kansas +5.5; Over/Under:  50.5 points

Bet365:  Point Spread:  Mizzou -5.5, Kansas +5.5; Over/Under:  50.5 points

BetMGM:  Point Spread:  Mizzou -5.5, Kansas +5.5; Over/Under:  50.5 points

Missouri Tigers:  1-0 (0-0) (1st place, SEC)

Kansas Jayhawks:  1-0 (0-0) (1st place, Big 12)

Do not miss out on our expert handicapper analysis! Jack Banks is on a HOT STREAK in college football on a 6-0 CFB RUN for +$6,000 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Missouri Tigers:  won their last game at home against the Arkansas-Pine Bluff Golden Lions 54-14.

Kansas Jayhawks:  won their last game at home against the LIU Sharks 51-6.

Missouri is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Arkansas-Pine Bluff 54-14. Austin Simmons was the starting QB and he completed 17/19 passes for 252 passing yards, 4 touchdowns, and 0 interceptions. Jamal Roberts led the team in rushing yards with 47 and 1 TD. Donovan Olugbode led the receivers with 116 receiving yards on 8 receptions and 2 TDs. Elijah Dotson and Jason Dowell each led the defense in that game with 1 tackle while Jason Dowell led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

Kansas is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against LIU 51-6. Isaiah Marshall was the starting QB and he completed 14/19 passes for 246 passing yards, 2 touchdowns, and 0 interceptions. Yasin Willis led the team in rushing yards with 72 and 2 TDs. Nik McMillan led the receivers with 130 receiving yards on 6 receptions and 1 TD. Joseph Credit, Trey Lathan, David Santiago, and Daveon Crouch each led the defense in that game with 1 tackle while Joseph Credit, Trey Lathan, and Daveon Crouch each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Kansas listed as a 5.5 point underdog in this game according to Draftkings Sportsbook. Kansas has a 1-0 record overall this season after destroying a team from the FCS in their season opener. They had a slower start in that game, but they eventually got rolling with a 51-6 win. The offense looked great with over 50 points scored and the defense didn't let LIU do much all day. They weren't really challenged in that game, but it was a good tune-up for them and now they are going to have the home advantage for this big rivalry game too. Meanwhile, Missouri has a 1-0 record overall this season and they also beat up on a team from the FCS in their season opener. They beat Arkansas-Pine Bluff 54-14, but the defense gave up quite a few points considering the talent level of the team they were playing. The points did come in the 2nd half as the game was over by halftime, but they weren't really challenged in that game either. Now they are playing their 1st road game of the season and their QB Austin Simmons still has a lot to prove. Missouri is entering this game ranked inside the top 25, but that is only going to motivate Kansas more to take them down a peg. Kansas lost this game on the road last season 42-31, but Missouri also pulled away late to win by double digits. That was a really close game for all 4 quarters and both teams had a chance to win it, so Kansas is definitely going to bring their best effort to get their revenge back at home. Even if Mizzou squeaks this game out on the road, it won't be by much. The best way to place a bet here is on Kansas to cover the spread in this game. 

Missouri Kansas Prediction:  Our NCAAF Pick for Friday, September 11, 2026 (8:00 pm ET start time) is Missouri 34 Kansas 30.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Missouri Tigers Kansas Jayhawks prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

Missouri Tigers: 13-6 ATS as a favorite. 8-4 ATS when the total is between 49.5 and 56. 6-3 ATS after scoring 37 points or more last game. 6-3 UNDER in road lined games. 

Kansas Jayhawks: 2-5 ATS in non-conference games. 1-3 ATS off a home win by 17 points or more. 6-3 UNDER in the first month of the season. 

Missouri Tigers:  G. Hoffman (TE) Questionable - Undisclosed. A. Hardy (RB) Questionable - Leg. J. Brady (WR) Questionable - Undisclosed. C. Green (OG) Questionable - Undisclosed.

Kansas Jayhawks:  C. Moses (TE) Questionable - Undisclosed. C. Pickett (WR) Questionable - Leg. K. Amachree (RB) Out - Undisclosed. J. Thurman (RB) Out - Undisclosed.

“We had a few good runs. We didn't cover up our second-level defenders the way we needed to. Those are things that we have to get fixed in a hurry if we're going to run the ball with the effectiveness we need to.” - Eili Drinkwitz after his team’s win against Arkansas-Pine Bluff in their last game. 

"We're good that way. We didn't have to burn anything, and it wasn't that way timeout-wise. I think we've done a lot of work on that in practice. In other situations, we're pretty good at what we're doing, and again, with what we use tonight." - Lance Leipold on in-game operations after his team’s win against LIU in their last game. 

WR Goodie Sr., Caleb

WR Olugbode, Donovan

WR Lee, Cayden

TE Norfleet, Brett

QB Simmons, Austin

RB Roberts, Jamal

WR McMillan, Nik

WR Cox, Nahzae

WR Pickett, Cam

TE Bruhn, Carson

QB Marshall, Isaiah

RB Edwards, Dylan

Passing: Austin Simmons (252)

Rushing: Jamal Roberts (47)

Receiving: Donovan Olugbode (107)

Touchdowns: Donovan Olugbode (2)

Passing: Isaiah Marshall (246)

Rushing: Yasin Willis (72)

Receiving: Nik McMillan (130)

Touchdowns: Yasin Willis (2)

Coaches:

Missouri Tigers: Eli Drinkwitz (7th season)

Kansas Jayhawks: Lance Leipold (6th season)