Mississippi Rebels vs Vanderbilt Commodores Prediction, Picks and Game Preview - 10/10/2026

Game Time: 3:30 pm ET, Saturday, October 10, 2026

Venue:  FirstBank Stadium, Nashville, TN

Where to Watch:  ESPN

DraftKings:  Point Spread:  Ole Miss -9.5, Vandy +9.5; Over/Under:  57.5 points

Bet365:  Point Spread:  Ole Miss -9.5, Vandy +9.5; Over/Under:  57.5 points

BetMGM:  Point Spread:  Ole Miss -10, Vandy +10; Over/Under:  57.5 points

Mississippi Rebels:  3-1 (1-1) (7th place, SEC)

Vanderbilt Commodores:  3-2 (0-2) (14th place, SEC)

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Mississippi Rebels:  lost their last game on the road against the Florida Gators 52-28.

Vanderbilt Commodores:  lost their last game on the road against the Georgia Bulldogs 38-14.

Ole Miss is entering this game with a 3-1 record overall and they have a 1-1 record in their conference games too. They are 2-0 in their home games, 0-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Florida 52-28. Trinidad Chambliss was the starting QB and he completed 25/34 passes for 298 passing yards, 1 touchdown, and 1 interception. Trinidad Chambliss led the team in rushing yards with 44 and 2 TDs. Deuce Alexander led the receivers with 134 receiving yards on 7 receptions and 1 TD. Keaton Thomas led the defense in that game with 11 tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

 

 

 

Vanderbilt is entering this game with a 3-2 record overall and they have a 0-2 record in their conference games too. They are 3-0 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Georgia 38-14. Blaze Berlowitz was the starting QB and he completed 12/23 passes for 190 passing yards, 1 touchdown, and 1 interception. Blaze Berlowitz led the team in rushing yards with 37. Junior Sherrill led the receivers with 107 receiving yards on 7 receptions and 1 TD. CJ Heard led the defense in that game with 9 tackles while CJ Heard led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Ole Miss listed as a 9.5 point favorite in this game according to Draftkings Sportsbook. Ole Miss has looked good in their games this season with their 3-1 record overall and their 1-1 conference record which has them right in the middle of the SEC. They haven't been a great road team though with their 0-1 road record this year. Meanwhile, Vanderbilt has looked good in their games this season with their 3-2 record overall, but their 0-2 conference record has them right near the bottom of the SEC. They have looked a lot better on their home field though with their 3-0 home record this season. Vanderbilt is coming off a great season going 10-2, but a lot of that magic came with Diego Pavia and that seems to be gone now. They are coming off a 38-14 loss to Georgia in their last one and they have had a lot of trouble against some mediocre opponents in their wins this season. Their offense has had trouble against good defenses and they really aren't going to re-create what they had last season. Ole Miss is in a similar boat, being the remnants of the team that Lane Kiffin built, but they still have a lot of talent to get them through this season along with one of the best QB's in the nation. The defense hasn't looked great this year, but they have had more than a week off to fix that, coming out of their bye week after losing their last game to Florida 52-28. The defense will look better against this weaker Vandy offense and Ole Miss also has a really good offense that is going to put up a ton of points here and will be able to run away with this game. Look for Ole Miss to bounce back coming out of their bye week and beat up on a Vanderbilt team that is heading right back to the bottom of the SEC. The best way to place a bet here is on Ole Miss to cover the spread in this game. 

Mississippi Vanderbilt Prediction:  Our NCAAF Pick for Saturday, October 10, 2026 (3:30 pm ET start time) is Ole Miss 34 Vanderbilt 17.

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Mississippi Rebels: 6-3 ATS after playing their last game on the road. 4-1 ATS when playing against a good team (Win Pct. 60% to 75%). 10-5 ATS on the road after a game with a turnover margin of -2 or worse. 30-11 UNDER as a road favorite. 25-10 UNDER after a game with a turnover margin of -2 or worse.

Vanderbilt Commodores: 16-28 ATS as a home underdog of 7.5 to 14 points. 11-17 ATS when the total is between 56.5 and 63. 23-31 ATS versus poor rushing teams - averaging 120 rushing yards/game or less. 33-21 UNDER as an underdog of 3.5 to 10 points. 10-5 UNDER against teams with a turnover margin of -1 per game or worse.

Mississippi Rebels:  K. Lacy (RB) Out - Shoulder. M. Frazier (RB) Questionable - Undisclosed.

Vanderbilt Commodores:  J. Curtis (LB) Questionable - Undisclosed. J. Curtis (QB) Questionable - Undisclosed. K. Smith (WR) Out - Undisclosed.

“That was an old-fashioned butt-whupping.” - Pete Golding after his team’s loss against Florida in their last game. 

“I’m proud of Blaze. I thought he played with courage. And it wasn’t perfect, but he showed the ability to make some plays with his legs. He was able to connect with Junior [Sherrill] in some critical moments.” - Clark Lea after his team’s loss against Georgia in their last game. 

WR Alexander, Deuce

WR Fields, Horatio

WR Cook II, Johntay

TE Hasz, Luke

QB Chambliss, Trinidad

RB Lacy, Kewan

WR Sherrill, Junior

WR Coleman, Brycen

WR Brown, Tristen

TE Conner, Jayvontay

QB Curtis, Jared

RB Alexander, Sedrick

Passing: Trinidad Chambliss (1,222)

Rushing: Kewan Lacy (191)

Receiving: Deuce Alexander (429)

Touchdowns: Kewan Lacy (4)

Passing: Jared Curtis (746)

Rushing: Sedrick Alexander (200)

Receiving: Junior Sherrill (474)

Touchdowns: Sedrick Alexander (5)

Coaches:

Mississippi Rebels: Pete Golding (1st season)

Vanderbilt Commodores: Clark Lea (6th season)