Mississippi Rebels vs Oklahoma Sooners Prediction, Picks and Game Preview - 10/25/2025

Game Time: 12:00 pm ET, Saturday, October 25, 2025

Venue:  Gaylord Family - Oklahoma Memorial Stadium, Norman, OK

Where to Watch:  ABC

DraftKings:  Point Spread:  Ole Miss +4, Oklahoma -4; Over/Under:  52.5 points

Bet365:  Point Spread:  Ole Miss +4.5, Oklahoma -4.5; Over/Under:  52.5 points

BetMGM:  Point Spread:  Ole Miss +4.5, Oklahoma -4.5; Over/Under:  52.5 points

Mississippi Rebels:  6-1 (3-1) (4th place, SEC)

Oklahoma Sooners:  6-1 (2-1) (7th place, SEC)

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Mississippi Rebels:  lost their last game on the road against the Georgia Bulldogs 43-35.

Oklahoma Sooners:  won their last game on the road against the South Carolina Gamecocks 26-7.

Ole Miss is entering this game with a 6-1 record overall and they have a 3-1 record in their conference games too. They are 5-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Georgia 43-35. Trinidad Chambliss was the starting QB and he completed 19/36 passes for 263 passing yards, 1 touchdown, and 0 interceptions. Trinidad Chambliss led the team in rushing yards with 42 and 2 TDs. De'Zhaun Stribling led the receivers with 96 receiving yards on 3 receptions and 1 TD. TJ Dottery led the defense in that game with 7 solo tackles and 2 assisted tackles while Zxavian Harris led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

Oklahoma is entering this game with a 6-1 record overall and they have a 2-1 record in their conference games too. They are 4-0 in their home games, 2-0 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They won their last game against South Carolina 26-7. John Mateer was the starting QB and he completed 18/26 passes for 150 passing yards, 1 touchdown, and 0 interceptions. Tory Blaylock led the team in rushing yards with 101 and 1 TD. Isaiah Sategna led the receivers with 73 receiving yards on 7 receptions and 1 TD. Robert Spears-Jennings led the defense in that game with 7 solo tackles and 1 assisted tackle while R Mason Thomas each led the defense in sacks with 1.5. Taylor Wein and Jacobe Johnson each came away with 1 interception for them in that one.

The current betting odds have Oklahoma listed as a 4 point favorite in this game according to Draftkings Sportsbook. Oklahoma has looked really good in their games this season with their 6-1 record overall which has them right near the top of the SEC and ranked inside the top 25. Their only loss came in the Red River Rivalry to Texas, but they bounced back nicely in their last one with a 26-7 win over South Carolina. Their defense looked great in that win and they have had one of the best defenses in the SEC all season. Meanwhile, Ole Miss has also looked really good in their games this season with their 6-1 record overall which has them right near the top of the SEC and ranked inside the top 25. They are off their first loss of the season though, losing 43-35 against Georgia. Their offense looked really good in that game as they were still able to put up 35 points and were leading for most of that game, but they crumbled in the 4th quarter with Georgia storming back and that Ole Miss defense is still a really big issue for them. They were able to outscore opponents up until this point in the season, but they struggled to keep a lead against an elite Georgia team and they are going to be seeing another elite team in Oklahoma who does have one of the best defenses in the conference. Oklahoma also has a good offense that can put up points on this Ole Miss defense so Oklahoma has a big advantage at home with the better defensive unit. The best way to place a bet here is on Oklahoma to cover the spread in this game. 

Mississippi Oklahoma Prediction:  Our NCAAF Pick for Saturday, October 25, 2025 (12:00 pm ET start time) is Oklahoma 27 Ole Miss 20.

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Mississippi Rebels: 0-3 ATS as a road underdog. 4-7 ATS versus good rushing defenses - allowing 120 rushing yards/game or less. 8-4 UNDER in road lined games. 13-7 UNDER against conference opponents. 8-4 UNDER versus good rushing defenses - allowing 120 rushing yards/game or less.

Oklahoma Sooners: 10-4 ATS as a home favorite. 7-3 ATS after playing their last game on the road. 4-1 ATS off a road win. 5-0 UNDER when the total is between 49.5 and 56. 4-0 UNDER off 3 or more consecutive unders. 9-5 UNDER vs. good offensive  teams - scoring 31 or more points/game.

Mississippi Rebels:  L. Clardy (S) Questionable - Undisclosed.

Oklahoma Sooners:  K. Dolby (CB) Questionable - Undisclosed. J. Barnes (RB) Questionable - Undisclosed. K. Lewis (WR) Questionable - Undisclosed. L. Howland (OG) Questionable - Undisclosed. J. Taylor (OG) Questionable - Undisclosed. J. Sexton (OG) Questionable - Undisclosed. K. McIntyre (TE) Questionable - Undisclosed. T. Everett (OG) Out - Undisclosed.

“In the fourth quarter, they made a lot of plays, both sides of the ball. I told my guys this is exactly what you want. Going into the fourth quarter you are up two scores at Georgia. You have to keep scoring. We did not do that in the fourth quarter.” - Lane Kiffin after his team’s loss against UGA in their last game. 

“Whenever anybody questioned our team from a week ago, our guys had the ability to block it out.” - Brent Venables after his team’s win against South Carolina in their last game. 

WR Wallace III, Harrison

WR Stribling, De'Zhaun

WR Lee, Cayden

TE Hasz, Luke

QB Simmons, Austin

RB Lacy, Kewan

WR Lewis, Keontez

WR Burks, Deion

WR Sategna III, Isaiah

TE Kanak, Jaren

QB Mateer, John

RB Blaylock, Tory

Passing: Trinidad Chambliss (1,549)

Rushing: Kewan Lacy (618)

Receiving: Harrison Wallace III (400)

Touchdowns: Kewan Lacy (10)

Passing: John Mateer (1,567)

Rushing: Tory Blaylock (391)

Receiving: Isaiah Sategna III (493)

Touchdowns: John Mateer (5)

Coaches:

Mississippi Rebels: Lane Kiffin (6th season)

Oklahoma Sooners: Brent Venables (4th season)