Mississippi Rebels vs Kentucky Wildcats Prediction, Picks and Game Preview - 09/06/2025

Game Time: 3:30 pm ET, Saturday, September 6, 2025

Venue:  Kroger Field, Lexington, KY

Where to Watch:  ABC

DraftKings:  Point Spread:  Ole Miss -10, Kentucky +10; Over/Under:  52.5 points

Bet365:  Point Spread:  Ole Miss -10, Kentucky +10; Over/Under:  52.5 points

BetMGM:  Point Spread:  Ole Miss -10, Kentucky +10; Over/Under:  52.5 points

Mississippi Rebels:  1-0 (0-0) (1st place, SEC)

Kentucky Wildcats:  1-0 (0-0) (12th place, SEC)

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Mississippi Rebels:  won their last game at home against the Georgia State Panthers 63-7.

Kentucky Wildcats:  won their last game at home against the Toledo Rockets 24-16. 

Ole Miss is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Georgia State 63-7. Austin Simmons was the starting QB and he completed 20/31 passes for 341 passing yards, 3 touchdowns, and 2 interceptions. Kewan Lacy led the team in rushing yards with 108 and 3 TDs. Harrison Wallace III led the receivers with 130 receiving yards on 5 receptions and 1 TD. TJ Dottery led the defense in that game with 5 solo tackles and 4 assisted tackles while Zxavian Harris led the defense in sacks with 1. Zxavian Harris came away with the only interception for them in that one.

 

 

 

Kentucky is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Toledo 24-16. Zach Calzada was the starting QB and he completed 10/23 passes for 85 passing yards, 0 touchdowns, and 1 interception. Dante Dowdell led the team in rushing yards with 129 and 1 TD. Josh Kattus led the receivers with 43 receiving yards on 3 receptions. Alex Afari Jr. led the defense in that game with 9 solo tackles and 4 assisted tackles while Steven Soles Jr. led the defense in sacks with 2. Jonquis Hardaway came away with the only interception for them in that one.

The current betting odds have Ole Miss listed as a 10 point favorite in this game according to Draftkings Sportsbook. Ole Miss is 1-0 overall and they looked great in their season opener. They did play a lesser opponent at home, beating Georgia State 63-7, but they still beat a team from the FBS in an embarrassing fashion. The defense looked good, only giving up the 1 touchdown, and the offense looked like they picked up right where they left off last season even though Dart is no longer there. Simmons had a solid game and he has a ton of talent in the offense to work with so they are going to put up points in this one. Meanwhile, Kentucky is 1-0 overall after winning their season opener, but they didn't look good in that win. They struggled to beat Toledo 24-16 at home and their offense looked terrible at times. They were able to run the ball well, but they had no passing game with Zach Calzada and it isn't going to get any better in this game against a better defense. The Kentucky defense looked really good in that game and they pretty much won the game for Kentucky so they will get some stops here and make it harder for Ole Miss to score, but they will likely be on the field a lot due to that offense and that will allow Ole Miss to pull away throughout the game. Kentucky's defense will only keep them in this game for so long, but eventually the offense just won't be able to keep up with Ole Miss. The best way to place a bet here is on Ole Miss to cover the spread in this game. 

Mississippi Kentucky Prediction:  Our NCAAF Pick for Saturday, September 6, 2025 (3:30 pm ET start time) is Mississippi 35 Kentucky 14.

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Mississippi Rebels: 16-9 ATS in all lined games. 13-7 ATS as a favorite. 7-3 ATS after allowing 14 points or less last game. 7-1 UNDER as a road favorite. 7-1 UNDER off a home win by 17 points or more. 

Kentucky Wildcats: 1-3 ATS as a home underdog. 2-6 ATS at home against conference opponents. 4-7 1H ATS after 1 or more consecutive straight up wins. 5-2 UNDER off a home win. 11-5 1H UNDER in home lined games.

Mississippi Rebels:  D. Wright (TE) Questionable - Undisclosed. L. Hasz (TE) Out - Ankle.

Kentucky Wildcats:  J. Wilcox (RB) Questionable - Personal.

“I was really pleased with the offensive balance. We’ve got things to work on too. We had the two turnovers, and we’ve got to tackle better. Obviously, we’ve got a huge challenge next week.” - Lane Kiffin after his team’s win against GA State in their last game. 

"I don’t think (the players) are satisfied, but we will take the victory at any time. I thought we did some good things early in the game in particular. Defense was playing very good. Offensively, I felt like we were going to get in a rhythm and we hurt ourselves. There’s things that we did to shoot ourselves in the foot that we have to get corrected, but we overcame those bad plays and won the game.” - Mark Stoops after his team’s win against Toledo in their last game. 

WR Wallace III, Harrison

WR Stribling, De'Zhaun

WR Lee, Cayden

TE Wright, Dae'Quan

QB Simmons, Austin

RB Lacy, Kewan

WR Gilmore IV, Hardley

WR Maclin, Ja'Mori

WR Law, Kendrick

TE Kattus, Josh

QB Calzada, Zach

RB Dowdell, Dante

Passing: A. Simmons (341)

Rushing: K. Lacy (108)

Receiving: H. Wallace III (130)

Touchdowns: K. Lacy (3)

Passing: Z. Calzada (85)

Rushing: D. Dowdell (129)

Receiving: J. Kattus (43)

Touchdowns: D. Dowdell (1)

Coaches:

Mississippi Rebels: Lane Kiffin (6th season)

Kentucky Wildcats: Mark Stoops (13th season)