Minnesota Twins vs New York Yankees Prediction, Preview and Odds - 08/13/2025

Game Time: 7:05 pm ET, Wednesday, August 13, 2025

Venue:  Yankee Stadium, Bronx, NY 

Where to Watch:  Prime Video

DraftKings:  Moneyline odds:  Twins +112, Yankees -137; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Twins +115, Yankees -135; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Twins +115, Yankees -135; Over/Under:  8.5 runs

Minnesota Twins:  56-62 (4th place, AL Central)

New York Yankees:  63-56 (3rd place, AL East)

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Minnesota Twins:  5-5 last 10

New York Yankees:  3-7 last 10

The Twins are entering this series off a win and won their 3-game series against the Kansas City Royals 2-1 in their last series. They enter this game with a 56-62 record overall and have a road record of 24-37. This is the series finale of a 3-game series with the Yankees on Wednesday with the 2nd game still to be played on Tuesday. The Twins lost the series opener on Monday. Their offense ranks 16th in the MLB with a .711 OPS. Thomas Hatch is their starting pitcher on Tuesday while Joe Ryan is making his start in this game on Wednesday. He is 11-5 with a 2.79 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 1 HR, and 0 BB with 5 SO on 4 hits through 5 IP against the Kansas City Royals.

The Yankees are entering this series off a loss and lost their 3-game series against the Houston Astros 2-1 in their last series. They enter this game with a 63-56 record overall and have a home record of 36-24. This is the 3rd game of a 3-game series with the Twins on Wednesday with the 2nd game of this series still to be played on Tuesday. The Yankees won the series opener on Monday. Their offense ranks 1st in the MLB with a .773 OPS. Carlos Rodón is their starting pitcher on Tuesday while rookie pitcher Cam Schlittler is making his start in this game on Wednesday. He is 1-2 with a 4.38 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 1 walk with 3 strikeouts on 7 hits through 5 innings pitched against the Houston Astros.

The current betting odds have the Twins listed as an underdog in this game according to Draftkings Sportsbook. The Yankees have looked good in their games this season with their 63-56 record overall which has them right in the middle of the AL East. They have looked great in their own ballpark this year too with their 36-24 home record. Meanwhile, the Twins haven't looked good in their games this season with their 56-62 record overall which has them right near the bottom of the AL Central. They have been a terrible road team too with their 24-37 road record this year. As bad as the Twins have been this year, they have been the better team lately as they are 5-5 in their last 10 games while the Yankees are 3-7 and have been in a slump for weeks. The Yankees were leading the AL East for most of the year and have slipped to 3rd over the last few weeks. The Twins traded away a lot of players at the trade deadline, but they haven't looked bad since doing that and they are going to have the better pitching matchup here too. Ryan is on the mound for the Twins in this one and he has looked great this season. He is 11-5 with a 2.79 ERA and the team has had a lot of success with him this year. They have lost 2 of their last 3 games with him starting, but that hasn't been a common theme with him on the mound and he is coming off a good start in which he only gave up 1 earned run too. Schlittler is on the mound for the Yankees in this one and he hasn't looked great this season. He is 1-2 with a 4.38 ERA and the team hasn't had a ton of success with him starting. He only gave up 2 earned runs in his last start, but that hasn't been a common theme for him this year, and the team has lost 3 games in a row now with him starting too. Ryan is going to give the Twins their best chance to take a game in this series. The best way to place a bet here is on the Twins to win this game. 

Twins Yankees Prediction:  Our MLB Pick for Wednesday, August 13, 2025 (7:05 pm ET start time) is Twins 3 Yankees 2.

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Minnesota Twins: 13-9 (+4.5 units) on the moneyline against AL East opponents. 13-10 (+4.9 units) on the moneyline vs. good power teams - averaging 1.25 or more HR's/game. 11-4 (+6.5 units) on the moneyline vs. a starting pitcher who gives up 1 or more HR's/starts. 7-3 UNDER vs. AL teams scoring 4.9 or more runs/game on the season.

New York Yankees: 63-57 (-19.6 units) on the moneyline in all games. 36-24 (-4.3 units) on the moneyline in home games. 50-44 (-15.3 units) on the moneyline against right-handed starters. 12-3 UNDER against AL Central opponents.

Minnesota Twins:  C. Vazquez (C) Ten Day IL - Shoulder. S. Woods Richardson (SP) Fifteen Day IL - Illness. A. Misiewicz (RP) Fifteen Day IL - Shoulder. D. Festa (SP) Fifteen Day IL - Shoulder. P. Lopez (SP) Sixty Day IL - Shoulder.

New York Yankees:  A. Rosario (3B) Ten Day IL - Joint. A. Slater (LF) Ten Day IL - Hamstring. J. Loaisiga (RP) Fifteen Day IL - Back. C. Schmidt (SP) Sixty Day IL - Forearm. F. Cruz (RP) Fifteen Day IL - Oblique. R. Yarbrough (SP) Fifteen Day IL - Oblique. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. G. Cole (SP) Sixty Day IL - Elbow.

“[Buxton] comes in, hits a sweeper over the left-field wall. It’s good. He took some good-looking swings. Connected on one of them. We’ll take it. It was good to have him back in the lineup. He always does something good for the team.” - Rocco Baldelli after his team’s loss against the Yankees in their game on Monday.

“He filled up the strike zone. You saw swing and miss with the heater. I thought the sweeper was good. He was on the attack. Big performance. That’s what it’s supposed to look like right there.” - Aaron Boone after his team’s win against the Twins in their game on Monday.

Byron Buxton (R) CF

Kody Clemens (L) LF

Ryan Jeffers (R) C

Luke Keaschall (R) DH

Trevor Larnach (L) RF

Brooks Lee (S) SS

Royce Lewis (R) 3B

Edouard Julien (L) 1B

Ryan Fitzgerald (L) 2B

Trent Grisham (L) CF

Aaron Judge (R) DH

Cody Bellinger (L) LF

Giancarlo Stanton (R) RF

Ben Rice (L) C

Jazz Chisholm Jr. (L) 2B

Paul Goldschmidt (R) 1B

Ryan McMahon (L) 3B

Anthony Volpe (R) SS

Batting Average:  Luke Keaschall (.386)

Hits:  Byron Buxton (93)

Home Runs:  Byron Buxton (24)

RBI:  Byron Buxton (60)

Stolen Bases:  Byron Buxton (17)

Wins:  Joe Ryan (11)

Saves:  Jhoan Duran (16)

ERA:  Thomas Hatch (0.00)

Batting Average:  Amed Rosario (.429)

Hits:  Aaron Judge (133)

Home Runs:  Aaron Judge (37)

RBI:  Aaron Judge (87)

Stolen Bases:  Jasson Domínguez (19)

Wins:  Max Fried (12)

Saves:  Devin Williams (17)

ERA:  Adam Ottavino (0.00)

Managers:

Minnesota Twins: Rocco Baldelli (7th season)

New York Yankees: Aaron Boone (8th season)