Minnesota Twins vs Houston Astros Prediction, Preview and Odds - 07/01/2026

Game Time: 8:10 pm ET, Wednesday, July 1, 2026

Venue:  Daikin Park, Houston, TX 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Twins +104, Astros -126; Over/Under:  8 runs

Bet365:  Moneyline odds:  Twins +105, Astros -125; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Twins +105, Astros -125; Over/Under:  8.5 runs

Minnesota Twins:  41-45 (3rd place, AL Central)

Houston Astros:  42-45 (3rd place, AL West)

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Minnesota Twins:  5-5 last 10

Houston Astros:  6-4 last 10

The Twins are entering this series off a win and won their 3-game series against the Colorado Rockies 2-1 in their last series. They enter this game with a 41-45 record overall and have a road record of 19-22. This is the series finale of a 3-game series with the Astros on Wednesday with the 2nd game still to be played on Tuesday. The Twins won the series opener on Monday. Their offense ranks 9th in the MLB with a .734 OPS. Joe Ryan is their starting pitcher on Tuesday while Taj Bradley is making his start in this game on Wednesday. He is 6-3 with a 3.98 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 3 BB with 7 SO on 3 hits through 7 IP against the Colorado Rockies.

The Astros are entering this series off a win and won their 4-game series against the Detroit Tigers 3-1 in their last series. They enter this game with a 42-45 record overall and have a home record of 20-22. This is the 3rd game of a 3-game series with the Twins on Wednesday with the 2nd game of this series still to be played on Tuesday. The Astros lost the 1st game of this series on Monday. Their offense ranks 12th in the MLB with a .725 OPS. Mike Burrows is their starting pitcher on Tuesday while Tatsuya Imai is making his start in this game on Wednesday. He is 5-3 with a 5.36 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 1 walk with 10 strikeouts on 2 hits through 6 innings pitched against the Detroit Tigers.

The current betting odds have the Twins listed as a slight underdog in this game according to Draftkings Sportsbook. The Twins haven't looked good in their games this season with their 41-45 record overall which has them right in the middle of the AL Central. They haven't been a great road team either with their 19-22 road record this year. Meanwhile, the Astros haven't looked great in their games this season with their 42-45 record overall which has them right in the middle of the AL West. They haven't looked great in their own ballpark either with their 20-22 home record this season. The Astros have been rolling lately as they are 6-4 in their last 10 games and have been working their way back toward .500, but they already dropped the 1st game of this series and even though the Twins are only 5-5 in their last 10 games, they have looked a lot better lately as they are trying to get back to .500. The Twins are going with Bradley in this one and he hasn't looked bad this season. He is 6-3 with a 3.98 ERA and the team has been having a lot of success with him lately. They have won 3 games in a row now with him starting and he is coming off another great start in which he gave up 2 earned runs. The Astros are going with Imai in this one and he hasn't looked great this year. He is 5-3 with a 5.36 ERA and he has been giving up quite a few runs lately. He is coming off a great start in which he gave up no runs and the team has even won 4 games in a row now with him starting, but that hasn't been a common theme for him this season and he is going to get into trouble with this Twins offense getting hot now. The Twins have had the better offense all season and they have been putting up a lot of runs lately too, so look for the Twins to take advantage of this pitching matchup. The best way to place a bet here is on the Twins to win this game. 

Twins Astros Prediction:  Our MLB Pick for Wednesday, July 1, 2026 (8:10 pm ET start time) is Twins 6 Astros 3.

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Minnesota Twins: 45-29 (+11.8 units) on the moneyline against AL West opponents. 28-23 (+9.2 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 29-21 (+11.6 units) on the moneyline when playing against a team with a losing record. 27-12 OVER in road games.

Houston Astros: 127-110 (-31 units) on the moneyline as a favorite of -110 or higher. 112-93 (-10.4 units) on the moneyline in home games. 106-92 (-13.4 units) on the moneyline when playing against a team with a losing record. 24-16 OVER in home games.

Minnesota Twins:  B. Buxton (CF) Day To Day - Hip. A. Banda (RP) Fifteen Day IL - Lat. B. Ober (SP) Fifteen Day IL - Elbow. R. Jeffers (C) Ten Day IL - Hand. G. Acton (RP) Sixty Day IL - Shoulder. C. Sands (RP) Fifteen Day IL - Forearm. M. Abel (SP) Fifteen Day IL - Elbow. D. Festa (SP) Sixty Day IL - Shoulder. P. Lopez (SP) Sixty Day IL - Elbow.

Houston Astros:  J. Pena (SS) Ten Day IL - Calf. L. Wade Jr. (1B) Ten Day IL - Hamstring. B. Shewmake (SS) Ten Day IL - Groin. C. Correa (SS) Sixty Day IL - Ankle. L. McCullers Jr. (SP) Fifteen Day IL - Shoulder. B. Sousa (RP) Fifteen Day IL - Elbow. C. Javier (SP) Sixty Day IL - Shoulder. H. Wesneski (RP) Sixty Day IL - Elbow. R. Blanco (SP) Sixty Day IL - Elbow. B. Walter (RP) Sixty Day IL - Elbow.

“Right now we’re at a day-to-day place. Over the course of the last week, we’ve seen how well he’s moved, we’ve seen him on the bases. (Sunday) it just didn’t look as comfortable. It felt like, ‘Let’s give him a little bit of a break.’” - Derek Shelton on the injury to Byron Buxton after his team’s win against the Astros in their game on Monday. 

“He competed. He gave us a shot to win there. He threw a lot of strikes like always. Just a couple pitches that stayed in the middle of the plate, a few home runs, but for the most part, typical Lambert. He competes, used all of his pitches. He keeps you in the game.” - Joe Espada after his team’s loss against the Twins in their game on Monday.

Trevor Larnach (L) LF

Brooks Lee (S) 3B

Kody Clemens (L) 2B

Josh Bell (S) DH

Royce Lewis (R) 1B

Victor Caratini (S) C

Ryan Kreidler (R) CF

Tristan Gray (L) SS

Luke Keaschall (R) RF

Jose Altuve (R) 2B

Yordan Alvarez (L) DH

Isaac Paredes (R) 3B

Christian Walker (R) 1B

Taylor Trammell (L) CF

Cam Smith (R) RF

Joey Loperfido (L) LF

Nick Allen (R) SS

Christian Vázquez (R) C

Batting Average:  Gabriel Gonzalez (.500)

Hits:  Byron Buxton (81)

Home Runs:  Byron Buxton (25)

RBI:  Josh Bell (53)

Stolen Bases:  Luke Keaschall (12)

Wins:  Bailey Ober (6)

Saves:  Yoendrys Gómez (8)

ERA:  Yoendrys Gómez (1.64)

Batting Average:  LaMonte Wade (.333)

Hits:  Yordan Alvarez (94)

Home Runs:  Yordan Alvarez (25)

RBI:  Yordan Alvarez (56)

Stolen Bases:  Cam Smith (9)

Wins:  Spencer Arrighetti (7)

Saves:  Josh Hader (7)

ERA:  Miguel Ullola (0.00)

Managers:

Minnesota Twins: Derek Shelton (1st season)

Houston Astros: Joe Espada (3rd season)