Milwaukee Brewers vs Pittsburgh Pirates Prediction, Preview and Odds - 07/10/2026

Game Time: 6:40 pm ET, Friday, July 10, 2026

Venue:  PNC Park, Pittsburgh, PA 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Brewers +114, Pirates -137; Over/Under:  8 runs

Bet365:  Moneyline odds:  Brewers +115, Pirates -135; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Brewers +110, Pirates -135; Over/Under:  8 runs

Milwaukee Brewers:  58-34 (1st place, NL Central)

Pittsburgh Pirates:  47-47 (4th place, NL Central)

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Milwaukee Brewers:  7-3 last 10

Pittsburgh Pirates:  5-5 last 10

The Brewers won their 3-game series against the Arizona Diamondbacks 2-1. They enter this game with a 58-34 record overall and have a road record of 29-16. This is the series opener of a 3-game series with the Pirates on Friday with the series finale of their series against the St Louis Cardinals still to be played on Thursday. The Brewers won the series opener on Monday, won the 2nd game on Tuesday, won the 3rd game on Tuesday, and lost the 4th game on Wednesday. Their offense ranks 9th in the MLB with a .734 OPS. Logan Henderson is their starting pitcher on Thursday while Brandon Sproat is making his start in this game on Friday. He is 3-4 with a 5.13 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 0 HR, and 3 BB with 4 SO on 5 hits through 4 IP against the Arizona Diamondbacks.

The Pirates are entering this series off a loss and lost their 3-game series against the Atlanta Braves 2-1 in their last series. They enter this game with a 47-47 record overall and have a home record of 24-24. This is the 1st game of a 3-game series with the Brewers on Friday. Their offense ranks 2nd in the MLB with a .763 OPS. Mitch Keller was their starting pitcher on Thursday while Braxton Ashcraft is making his start in this game on Friday. He is 9-3 with a 3.24 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 2 walks with 7 strikeouts on 6 hits through 5.2 innings pitched against the Washington Nationals.

The current betting odds have the Pirates listed as a favorite in this game according to Draftkings Sportsbook. The Pirates haven't looked great in their games this season with their 47-47 record overall which has them right near the bottom of the NL Central. They haven't looked great in their own ballpark either with their 24-24 home record this season. Meanwhile, the Brewers have looked great in their games this season with their 58-34 record overall which has them right at the top of the NL Central with one of the best records in MLB. They have been a great road team too with their 29-16 road record this year. The Brewers have been rolling lately and they are 7-3 in their last 10 games while the Pirates are only 5-5 in their last 10, but the Pirates do have one of the best offenses in the league and they are going to have the better pitching matchup too. Ashcraft is on the mound for the Pirates in this one and he has looked great this season. He is 9-3 with a 3.24 ERA and the team has been having a ton of success with him lately. They have won 4 games in a row now with him starting and he is coming off another great start in which he only gave up 1 earned run, something that has been a common theme for him. The Brewers are going with Sproat in this one and he hasn't looked good this season. He is 3-4 with a 5.13 ERA and he has been giving up a ton of runs all year. The team has had more success with him lately, winning 4 games in a row now with him starting, and he only gave up 1 earned run in his last start too, but that hasn't been a common theme for him this year and he is going to give up runs with how hot this Pirates offense has been. The Pirates have the edge at home here with the hotter offense and the better pitching matchup. The best way to place a bet here is on the Pirates to win this game. 

Brewers Pirates Prediction:  Our MLB Pick for Friday, July 10, 2026 (6:40 pm ET start time) is Pirates 6 Brewers 2.

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Milwaukee Brewers: 252-177 (+50.3 units) on the moneyline in all games. 121-92 (+32.2 units) on the moneyline in road games. 78-69 (+25.4 units) on the moneyline as an underdog of +100 or higher. 24-16 UNDER when the money line is +125 to -125.

Pittsburgh Pirates: 195-222 (-19.9 units) on the moneyline in all games. 82-67 (-11.8 units) on the moneyline as a favorite of -110 or higher. 59-72 (-12.9 units) on the moneyline against division opponents. 34-24 UNDER vs. a starting pitcher whose lasts less than 5 innings per start.

Milwaukee Brewers:  D. Hamilton (SS) Ten Day IL - Hamstring. B. Lockridge (LF) Sixty Day IL - Knee. J. Kuhnel (RP) Fifteen Day IL - Shoulder. B. Woodruff (SP) Fifteen Day IL - Shoulder. Q. Priester (SP) Sixty Day IL - Wrist. C. Crow (SP) Fifteen Day IL - Forearm. B. Fitzpatrick (RP) Sixty Day IL - Elbow. C. Rodriguez (RP) Fifteen Day IL - Shoulder. D. Hall (RP) Fifteen Day IL - Pectoral. R. Zastryzny (RP) Fifteen Day IL - Shoulder. A. Zerpa (RP) Sixty Day IL - Forearm. L. Henderson (SP) Fifteen Day IL - Back.

Pittsburgh Pirates:  E. Rodriguez (C) Ten Day IL - Lower Body. K. Griffin (SS) Ten Day IL - Finger. E. Sisk (RP) Fifteen Day IL - Elbow. S. Horwitz (1B) Ten Day IL - Hamstring. W. Dotel (RP) Fifteen Day IL - Lat. O. Cruz (CF) Ten Day IL - Hand. C. Devenski (RP) Sixty Day IL - Illness.

“It’s obvious he’s fatigued, and we’ve got to help him on that. We could have left him in there, but we’re thinking about his future.” - Pat Murphy on Kyle Harrison after his team’s loss against the Cardinals in their game on Wednesday.

“That sucks. Under normal circumstances, a perfect game, he'd continue to go. Coming off of surgery and everything, we just can't push him.” - Don Kelly after his team’s loss against the Braves in their game on Wednesday.

Christian Yelich (L) DH

Jackson Chourio (R) LF

Jake Bauers (L) 1B

William Contreras (R) C

Garrett Mitchell (L) CF

Luis Lara (S) RF

Cooper Pratt (R) SS

Joey Ortiz (R) 3B

Greg Jones (S) 2B

Jake Mangum (S) CF

Brandon Lowe (L) 2B

Bryan Reynolds (S) LF

Esmerlyn Valdez (R) RF

Ryan O'Hearn (L) DH

Nick Gonzales (R) 3B

Tyler Callihan (L) 1B

Rafael Flores Jr. (R) C

Jared Triolo (R) SS

Batting Average:  Tyler Black (.333)

Hits:  William Contreras (95)

Home Runs:  Jake Bauers (16)

RBI:  Jake Bauers (54)

Stolen Bases:  David Hamilton (18)

Wins:  Aaron Ashby (12)

Saves:  Trevor Megill (14)

ERA:  Easton McGee (0.00)

Batting Average:  Rafael Flores (.400)

Hits:  Nick Gonzales (101)

Home Runs:  Brandon Lowe (21)

RBI:  Brandon Lowe (64)

Stolen Bases:  Oneil Cruz (21)

Wins:  Braxton Ashcraft (9)

Saves:  Gregory Soto (11)

ERA:  Evan Sisk (2.23)

Managers:

Milwaukee Brewers: Pat Murphy (3rd season)

Pittsburgh Pirates: Don Kelly (2nd season)