Milwaukee Brewers vs Chicago Cubs Prediction, Preview and Odds - 09/02/2026

Game Time: 7:40 pm ET, Wednesday, September 2, 2026

Venue:  Wrigley Field, Chicago, IL

Where to Watch:  MLB TV, MLB Network

DraftKings:  Moneyline odds:  Brewers -163, Cubs +135; Over/Under:  8 runs

Bet365:  Moneyline odds:  Brewers -165, Cubs +135; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Brewers -160, Cubs +135; Over/Under:  8 runs

Milwaukee Brewers:  85-53 (1st place, NL Central)

Chicago Cubs:  78-60 (2nd place, NL Central)

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Milwaukee Brewers:  6-4 last 10

Chicago Cubs:  4-6 last 10

The Brewers are entering this series off a loss and won their 3-game series against the Texas Rangers 2-1 in their last series. They enter this game with an 85-53 record overall and have a road record of 38-28. This is the 3rd game of a 4-game series with the Cubs on Wednesday with the 2nd game still to be played on Tuesday. The Brewers lost the series opener on Monday. Their offense ranks 5th in the MLB with a .736 OPS. Robert Gasser is their starting pitcher on Tuesday while Jacob Misiorowski is making his start in this game on Wednesday. He is 14-5 with a 1.73 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 2 BB with 6 SO on 2 hits through 6 IP against the New York Mets.

The Cubs are entering this series off a loss and lost their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 78-60 record overall and have a home record of 40-29. This is the 3rd game of a 4-game series with the Brewers on Wednesday with the 2nd game of this series still to be played on Tuesday. The Cubs won the 1st game of this series on Monday. Their offense ranks 1st in the MLB with a .775 OPS. Matthew Boyd is their starting pitcher on Tuesday while David Peterson is making his start in this game on Wednesday. He is 7-7 with a 5.11 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 3 walks with 6 strikeouts on 6 hits through 5 innings pitched against the Cincinnati Reds.

The current betting odds have the Brewers listed as a favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 85-53 record overall which has them right at the top of the NL Central with the best record in MLB. They have been a good road team too with their 38-28 road record this year. Meanwhile, the Cubs have looked really good in their games this season with their 78-60 record overall which has them right near the top of the NL Central. They have looked good in their own ballpark too with their 40-29 home record this season. The Cubs took the 1st game of this series on Monday with a huge 17-3 win, but they really haven't looked that good lately. They are only 4-6 in their last 10 games while the Brewers are 6-4 and the Brewers are going to have the better pitching matchup in this one. The Brewers are going with Misiorowski in this one and he has looked great this season. He is 14-5 with a 1.73 ERA and he has been their ace this year. He is coming off another great start giving up 2 earned runs which has been a common theme for him all season and the team has been having a ton of success too, winning 4 games in a row now with him starting. The Cubs are going with Peterson in this one and he hasn't looked great this season. He is 7-7 with a 5.11 ERA and he has been giving up quite a few runs this year. He only gave up 2 earned runs in his last start, but that hasn't been a common theme for him and the team has still lost 2 games in a row now with him starting. This is a big series for the Brewers to keep the Cubs at a distance in the division and they are going to bring their best effort here with their best on the mound, so look for the Brewers to take advantage of this pitching matchup. The best way to place a bet here is on the Brewers to win this game. 

Brewers Cubs Prediction:  Our MLB Pick for Wednesday, September 2, 2026 (7:40 pm ET start time) is Brewers 7 Cubs 2.

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Milwaukee Brewers: 279-196 (+52.4 units) on the moneyline in all games. 130-104 (+27.1 units) on the moneyline in road games. 180-107 (+25.7 units) on the moneyline as a favorite of -110 or higher. 21-12 UNDER against division opponents.

Chicago Cubs: 76-72 (-6.2 units) on the moneyline against division opponents. 37-44 (-7.7 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 35-46 (-12.7 units) on the moneyline vs. a team with a good bullpen whose ERA is 3.45 or better. 22-14 UNDER as a home underdog of +100 or higher.

Milwaukee Brewers:  B. Wilson (RP) Fifteen Day IL - Back. J. Romero (RP) Fifteen Day IL - Appendix. R. Zastryzny (RP) Sixty Day IL - Shoulder. B. Woodruff (SP) Sixty Day IL - Shoulder. J. Kuhnel (RP) Fifteen Day IL - Shoulder. Q. Priester (SP) Sixty Day IL - Wrist. B. Fitzpatrick (RP) Sixty Day IL - Elbow. A. Zerpa (RP) Sixty Day IL - Forearm.

Chicago Cubs:  P. Maton (RP) Sixty Day IL - Knee. E. Cabrera (SP) Fifteen Day IL - Blister. D. Swanson (SS) Ten Day IL - Side. B. Brown (RP) Sixty Day IL - Neck. G. Hollowell (RP) Fifteen Day IL - Shoulder. R. Martin (RP) Sixty Day IL - Elbow. P. Hodge (RP) Sixty Day IL - Elbow. C. Horton (SP) Sixty Day IL - Forearm. H. Harvey (RP) Sixty Day IL - Tricep. J. Steele (SP) Sixty Day IL - Elbow. T. Austin (1B) Sixty Day IL - Knee. S. Miller (RP) Sixty Day IL - Elbow.

“I respect the heck out of them. I see a team with aptitude. I see a team that plays defense. I see a team that understands how to base run when it’s appropriate. And, I mean, they’ve got an explosive offense." - Pat Murphy after his team's loss against the Cubs in their game on Monday. 

“The position-player stuff gets a little ridiculous at the end there, honestly. That’s great we set a record. And the guys aren’t going to stop hitting. Guys are not going to stop hitting. They’re going to take advantage of it, and they should. They absolutely should. We’ll take it.” - Craig Counsell after his team’s win against the Brewers in their game on Monday. 

Brice Turang (L) 2B

Jackson Chourio (R) LF

Jake Bauers (L) 1B

William Contreras (R) C

Christian Yelich (L) DH

Garrett Mitchell (L) CF

Sal Frelick (L) RF

David Hamilton (L) 3B

Cooper Pratt (R) SS

Pete Crow-Armstrong (L) CF

Seiya Suzuki (R) RF

Alex Bregman (R) 3B

Tyrone Taylor (R) LF

Nico Hoerner (R) SS

Michael Busch (L) 1B

Carson Kelly (R) C

Miguel Amaya (R) DH

Matt Shaw (R) 2B

Batting Average:  Jihwan Bae (.500)

Hits:  William Contreras (132)

Home Runs:  Jake Bauers (23)

RBI:  Brice Turang (78)

Stolen Bases:  David Hamilton (24)

Wins:  Jacob Misiorowski (14)

Saves:  Trevor Megill (25)

ERA:  Easton McGee (0.00)

Batting Average:  Tyrone Taylor (.409)

Hits:  Pete Crow-Armstrong (150)

Home Runs:  Pete Crow-Armstrong (38)

RBI:  Pete Crow-Armstrong (91)

Stolen Bases:  Pete Crow-Armstrong (32)

Wins:  Colin Rea (8)

Saves:  Jacob Webb (9)

ERA:  Ty Blach (0.00)

Managers:

Milwaukee Brewers: Pat Murphy (3rd season)

Chicago Cubs: Craig Counsell (3rd season)