Milwaukee Brewers vs Chicago Cubs Prediction, Preview and Odds - 08/20/2025

Game Time: 8:05 pm ET, Wednesday, August 20, 2025

Venue:  Wrigley Field, Chicago, IL

Where to Watch:  FDSWI, MARQ

DraftKings:  Moneyline odds:  Brewers -115, Cubs -105; Over/Under:  NL runs

Bet365:  Moneyline odds:  Brewers -115, Cubs -105; Over/Under:  NL runs

BetMGM:  Moneyline odds:  Brewers -115, Cubs -105; Over/Under:  NL runs

Milwaukee Brewers:  79-45 (1st place, NL Central)

Chicago Cubs:  70-54 (2nd place, NL Central)

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Milwaukee Brewers:  9-1 last 10

Chicago Cubs:  4-6 last 10

The Brewers are entering this series off a loss and won their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 79-45 record overall and have a road record of 37-25. This is the 4th game of a 5-game series with the Cubs on Wednesday with the 2nd game and the 3rd game still to be played on Tuesday in a double header. The Brewers won the series opener on Monday. Their offense ranks 10th in the MLB with a .738 OPS. Brandon Woodruff is their starting pitcher on Tuesday while rookie pitcher Jacob Misiorowski is making his start in this game on Wednesday. He is 4-1 with a 3.89 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 5 ER, 0 HR, and 3 BB with 3 SO on 4 hits through 1.1 IP against the Cincinnati Reds.

The Cubs are entering this series off a win and won their 3-game series against the Pittsburgh Pirates 2-1 in their last series. They enter this game with a 70-54 record overall and have a home record of 38-24. This is the 4th game of a 5-game series with the Brewers on Wednesday with the 2nd game and the 3rd game of this series still to be played on Tuesday in a double header. Their offense ranks 6th in the MLB with a .750 OPS. Jameson Taillon is their starting pitcher on Tuesday while Colin Rea is making his start in this game on Wednesday. He is 9-5 with a 3.99 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 2 walks with 5 strikeouts on 3 hits through 5 innings pitched against the Pittsburgh Pirates.

The current betting odds have the Cubs listed as a slight underdog in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 79-45 record overall which has them right at the top of the NL Central with the best record in the entire MLB. They have also been a good road team this year with their 37-25 road record. Meanwhile, the Cubs have looked really good in their games this season with their 70-54 record overall which has them right near the top of the NL Central and in the division race. They have also looked great in their own ballpark this year with their 38-24 home record. The Brewers have been red hot lately as they are 9-1 in their last 10 games while the Cubs are only 4-6, but the Brewers finally lost a game after going on that long win streak and the Cubs can take advantage of them starting to cool off now. The Cubs are going with Rea in this one and he has looked good this season. He is 9-5 with a 3.99 ERA and he hasn't been giving up many runs lately. He did go through a rough patch, but he is back to his old ways now, coming off a good start in which he gave up 1 earned run and the team winning 2 of their last 3 games with him starting too. The Brewers are going with Misiorowski in this one and he has looked great this season too. He is 4-1 with a 3.89 ERA and the team has had a lot of success with him, winning 2 games in a row now with him starting. He did give up 5 earned runs in his last start though, starting to give up more runs lately, and that rookie magic is starting to wear off as teams figure him out now. This is a huge series for the Cubs to stay in this division race so they are going to bring their best effort in every game and they should have the edge in this one. The best way to place a bet here is on the Cubs to win this game. 

Brewers Cubs Prediction:  Our MLB Pick for Wednesday, August 20, 2025 (8:05 pm ET start time) is Cubs 4 Brewers 2.

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Milwaukee Brewers: 265-189 (+56.3 units) on the moneyline in all games. 127-99 (+36.5 units) on the moneyline in road games. 146-92 (+10.8 units) on the moneyline as a favorite of -110 or higher. 38-27 UNDER on the road against division opponents.

Chicago Cubs: 96-128 (-37 units) on the moneyline when the money line is +125 to -125. 147-158 (-22.5 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 20-26 (-6.6 units) on the moneyline vs. NL teams allowing 4.0 or less runs/game on the season. 30-23 UNDER as a home underdog of +100 or higher.

Milwaukee Brewers:  D. Hall (RP) Fifteen Day IL - Oblique. L. Henderson (SP) Fifteen Day IL - Elbow. J. Chourio (CF) Ten Day IL - Hamstring. J. Montgomery (SP) Sixty Day IL - Elbow. J. Bauers (LF) Ten Day IL - Shoulder. R. Hoskins (1B) Ten Day IL - Thumb. G. Mitchell (CF) Sixty Day IL - Oblique. R. Zastryzny (RP) Fifteen Day IL - Ribs. C. Thomas (SP) Sixty Day IL - Elbow. R. Gasser (SP) Sixty Day IL - Elbow.

Chicago Cubs:  C. Horton (SP) Day To Day - Finger. M. Amaya (C) Ten Day IL - Ankle. M. Soroka (SP) Fifteen Day IL - Shoulder. J. Taillon (SP) Fifteen Day IL - Calf. E. Morgan (RP) Sixty Day IL - Elbow. J. Steele (SP) Sixty Day IL - Elbow.

“I feel like if I think too much about what I have to do, I put pressure on myself. Normally, I don’t work like that. I have to be myself. Even in the morning before games, just be Freddy. I listen to music, play around, make some jokes and go out and compete without thinking to do so much.” - Freddy Peralta after their win against the Cubs in their game on Monday.

“The Brewers have played brilliantly. We don’t get a lot to say about that. And just credit to them -- they’ve done a good job. It’s made our position in the division kind of unfortunate, as you compare it to the other divisions, right? But, I think we’ve got a very good baseball team here. And we know that.” - Craig Counsell after his team’s loss against the Brewers in their game on Monday.

Brice Turang (L) 2B

Caleb Durbin (R) 3B

William Contreras (R) DH

Christian Yelich (L) LF

Andrew Vaughn (R) 1B

Blake Perkins (S) CF

Sal Frelick (L) RF

Danny Jansen (R) C

Joey Ortiz (R) SS

Michael Busch (L) 1B

Ian Happ (S) LF

Seiya Suzuki (R) DH

Pete Crow-Armstrong (L) CF

Willi Castro (S) 2B

Owen Caissie (L) RF

Dansby Swanson (R) SS

Reese McGuire (L) C

Matt Shaw (R) 3B

Batting Average:  Andrew Vaughn (.325)

Hits:  Brice Turang (125)

Home Runs:  Christian Yelich (25)

RBI:  Christian Yelich (86)

Stolen Bases:  Brice Turang (21)

Wins:  Freddy Peralta (15)

Saves:  Trevor Megill (29)

ERA:  Logan Henderson (1.78)

Batting Average:  Nico Hoerner (.291)

Hits:  Nico Hoerner (132)

Home Runs:  Pete Crow-Armstrong (27)

RBI:  Seiya Suzuki (86)

Stolen Bases:  Pete Crow-Armstrong (30)

Wins:  Matthew Boyd (11)

Saves:  Daniel Palencia (16)

ERA:  Michael Fulmer (0.00)

Managers:

Milwaukee Brewers: Pat Murphy (2nd season)

Chicago Cubs: Craig Counsell (2nd season)