Milwaukee Brewers vs Chicago Cubs Prediction, Preview and Odds - 08/19/2025

Game Time: 8:05 pm ET, Tuesday, August 19, 2025

Venue:  Wrigley Field, Chicago, IL

Where to Watch:  WITI, FDSWI, MARQ

DraftKings:  Moneyline odds:  Brewers +108, Cubs -132; Over/Under:  7 runs

Bet365:  Moneyline odds:  Brewers +110, Cubs -130; Over/Under:  7 runs

BetMGM:  Moneyline odds:  Brewers +110, Cubs -130; Over/Under:  7 runs

Milwaukee Brewers:  78-45 (1st place, NL Central)

Chicago Cubs:  70-53 (2nd place, NL Central)

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Milwaukee Brewers:  9-1 last 10

Chicago Cubs:  5-5 last 10

The Brewers are entering this series off a loss and won their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 78-45 record overall and have a road record of 36-25. This is the 3rd game of a 5-game series with the Cubs on Tuesday with the series opener and the 2nd game still to be played on Monday in a double header. Their offense ranks 8th in the MLB with a .739 OPS. Freddy Peralta is their starting pitcher on Monday while Brandon Woodruff is making his start in this game on Tuesday. He is 4-0 with a 2.06 ERA this season. His team won their last 7 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 ER, 0 HR, and 2 BB with 4 SO on 4 hits through 4 IP against the Pittsburgh Pirates.

The Cubs are entering this series off a win and won their 3-game series against the Pittsburgh Pirates 2-1 in their last series. They enter this game with a 70-53 record overall and have a home record of 38-23. This is the 3rd game of a 5-game series with the Brewers on Tuesday with the 1st game and the 2nd game of this series still to be played on Monday in a double header. Their offense ranks 6th in the MLB with a .752 OPS. Rookie pitcher Cade Horton is their starting pitcher on Monday while Matthew Boyd is making his start in this game on Tuesday. He is 11-6 with a 2.46 ERA this season. His team lost their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 1 walk with 5 strikeouts on 2 hits through 7 innings pitched against the Toronto Blue Jays.

The current betting odds have the Brewers listed as a slight underdog in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 78-45 record overall which has them right at the top of the NL Central with the best record in the entire MLB. They have also been a good road team this year with their 36-25 road record. Meanwhile, the Cubs have looked really good in their games this season with their 70-53 record overall which has them right near the top of the NL Central and in the division race. They have also looked great in their own ballpark this year with their 38-23 home record. The Cubs haven't looked great lately though as they are 5-5 in their last 10 games while the Brewers are 9-1 and have been rolling lately. The Brewers are going to have Woodruff on the mound here and he has looked great this season too. He is 4-0 with a 2.06 ERA and the team has been having a ton of success with him. He is coming off another great start in which he gave up no runs and the team has won 7 games in a row now with him starting too. The Cubs are going with Boyd in this one and he has also looked good this season. He is 11-6 with a 2.46 ERA, but lately he hasn't been at his best. He only gave up 2 earned runs in his last start, but lately he has been giving up more runs and the team hasn't had much success with him either, losing 4 games in a row now with him starting. The Brewers have been rolling lately, especially with their offense putting up a ton of runs, and Woodruff has been the better starter lately so the Brewers can edge out the Cubs here in this very important game for the division. The best way to place a bet here is on the Brewers to win this game. 

Brewers Cubs Prediction:  Our MLB Pick for Tuesday, August 19, 2025 (8:05 pm ET start time) is Brewers 3 Cubs 2.

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Milwaukee Brewers: 264-189 (+55.3 units) on the moneyline in all games. 126-99 (+35.5 units) on the moneyline in road games. 97-88 (+32.8 units) on the moneyline as an underdog of +100 or higher. 15-7 UNDER on the road vs. an NL starting pitcher whose ERA is 3.20 or better.

Chicago Cubs: 96-127 (-35.8 units) on the moneyline when the money line is +125 to -125. 147-157 (-21.3 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 20-25 (-5.4 units) on the moneyline vs. NL teams allowing 4.0 or less runs/game on the season. 13-6 UNDER at home vs. a starting pitcher who gives up 1 or more HR's/start.

Milwaukee Brewers:  D. Hall (RP) Fifteen Day IL - Oblique. L. Henderson (SP) Fifteen Day IL - Elbow. J. Chourio (CF) Ten Day IL - Hamstring. J. Montgomery (SP) Sixty Day IL - Elbow. J. Bauers (LF) Ten Day IL - Shoulder. R. Hoskins (1B) Ten Day IL - Thumb. G. Mitchell (CF) Sixty Day IL - Oblique. R. Zastryzny (RP) Fifteen Day IL - Ribs. C. Thomas (SP) Sixty Day IL - Elbow. R. Gasser (SP) Sixty Day IL - Elbow.

Chicago Cubs:  M. Amaya (C) Ten Day IL - Ankle. M. Soroka (SP) Fifteen Day IL - Shoulder. J. Taillon (SP) Fifteen Day IL - Calf. E. Morgan (RP) Sixty Day IL - Elbow. J. Steele (SP) Sixty Day IL - Elbow.

“It’s a reminder for our guys that every pitch matters and it ain’t over until it’s over. We know that because we’ve done it this week. But we’re showing signs of being human.” - Pat Murphy after his team’s loss against the Reds in their game on Sunday.

“What’s so great about it? The job is to try to win the division -- that’s kind of the ultimate goal. From our perspective, yeah, they’re making that part of the goal really hard to get to.” - Craig Counsell on the Brewers after his team’s win against the Pirates in their game on Sunday.

Brice Turang (L) 2B

Caleb Durbin (R) 3B

William Contreras (R) DH

Christian Yelich (L) LF

Andrew Vaughn (R) 1B

Blake Perkins (S) CF

Sal Frelick (L) RF

Danny Jansen (R) C

Joey Ortiz (R) SS

Michael Busch (L) 1B

Kyle Tucker (L) RF

Seiya Suzuki (R) DH

Pete Crow-Armstrong (L) CF

Carson Kelly (R) C

Owen Caissie (L) LF

Nico Hoerner (R) SS

Willi Castro (S) 2B

Matt Shaw (R) 3B

Batting Average:  Andrew Vaughn (.327)

Hits:  Jackson Chourio (123)

Home Runs:  Christian Yelich (25)

RBI:  Christian Yelich (86)

Stolen Bases:  Brice Turang (21)

Wins:  Freddy Peralta (14)

Saves:  Trevor Megill (29)

ERA:  Logan Henderson (1.78)

Batting Average:  Nico Hoerner (.293)

Hits:  Nico Hoerner (132)

Home Runs:  Pete Crow-Armstrong (27)

RBI:  Seiya Suzuki (86)

Stolen Bases:  Pete Crow-Armstrong (30)

Wins:  Matthew Boyd (11)

Saves:  Daniel Palencia (16)

ERA:  Michael Fulmer (0.00)

Managers:

Milwaukee Brewers: Pat Murphy (2nd season)

Chicago Cubs: Craig Counsell (2nd season)