Michigan Wolverines vs USC Trojans Prediction, Picks and Game Preview - 10/11/2025

Game Time: 7:30 pm ET, Saturday, October 11, 2025

Venue:  LA Memorial Coliseum, Los Angeles, CA

Where to Watch:  NBC

DraftKings:  Point Spread:  Michigan +2.5, USC -2.5; Over/Under:  57.5 points

Bet365:  Point Spread:  Michigan +2.5, USC -2.5; Over/Under:  57.5 points

BetMGM:  Point Spread:  Michigan +2.5, USC -2.5; Over/Under:  57.5 points

Michigan Wolverines:  4-1 (2-0) (4th place, Big Ten)

USC Trojans:  4-1 (2-1) (6th place, Big Ten)

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Michigan Wolverines:  won their last game at home against the Wisconsin Badgers 24-10.

USC Trojans:  lost their last game on the road against the Illinois Fighting Illini 34-32.

Michigan is entering this game with a 4-1 record overall and they have a 2-0 record in their conference games too. They are 3-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Wisconsin 24-10. Bryce Underwood was the starting QB and he completed 19/28 passes for 270 passing yards, 1 touchdown, and 0 interceptions. Justice Haynes led the team in rushing yards with 117 and 2 TDs. Donaven McCulley led the receivers with 112 receiving yards on 6 receptions and 1 TD. Jimmy Rolder led the defense in that game with 5 solo tackles and 2 assisted tackles while Derrick Moore led the defense in sacks with 1. Rod Moore came away with the only interception for them in that one.

 

 

 

USC is entering this game with a 4-1 record overall and they have a 2-1 record in their conference games too. They are 3-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Illinois 34-32. Jayden Maiava was the starting QB and he completed 30/43 passes for 364 passing yards, 2 touchdowns, and 1 interception. Waymond Jordan led the team in rushing yards with 94 and 2 TDs. Makai Lemon led the receivers with 151 receiving yards on 11 receptions and 2 TDs. Bishop Fitzgerald led the defense in that game with 6 solo tackles and 0 assisted tackles while DeCarlos Nicholson led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have USC listed as a 2.5 point favorite in this game according to Draftkings Sportsbook. USC has looked really good in their games this season with their 4-1 record overall and their 2-1 conference record which has them higher in the Big Ten. They just took their first loss of the season on the road against Illinois, but that was a really tight game that went back and forth. USC will be looking to bounce back now that they are back at home and they are coming out of their bye week so they do have an advantage here. Meanwhile, Michigan has looked really good in their games this season with their 4-1 record overall and their 2-0 conference record which has them higher in the Big Ten. Their only loss this season was against Oklahoma so they don't have a loss in the Big Ten yet, but they have definitely struggled more in their 2 road games. They are also off a 24-10 win at home against Wisconsin in their last one and they didn't look great in that game. Their defense has looked great this season, but even they have struggled in their 2 road games, and the offense has looked good at times but has still been really up and down from week to week. This isn't a great situation for Michigan to go on the road, especially when they played last week while USC is off a bye and looking to bounce back. The best way to place a bet here is on USC to cover the spread in this game. 

Michigan USC Prediction:  Our NCAAF Pick for Saturday, October 11, 2025 (7:30 pm ET start time) is USC 28 Michigan 24.

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Michigan Wolverines: 13-7 ATS against conference opponents. 9-4 ATS after allowing 14 points or less last game. 9-2 ATS when playing against a top-level team (Win Pct. > 75%). 4-0 OVER when the line is +3 to -3. 6-1 OVER on the road after allowing 14 points or less last game.

USC Trojans: 1-4 ATS after 3 or more consecutive losses against the spread. 7-14 ATS against conference opponents. 0-5 ATS against teams with a turnover margin of +1 per game or better. 20-10 OVER in all lined games. 7-2 OVER when the total is between 56.5 and 63.

Michigan Wolverines:  H. Hansen (TE) Probable - Undisclosed. M. Ka'apana (RB) Questionable - Undisclosed. D. Warren (QB) Questionable - Knee. D. Baxter (DL) Out - Undisclosed. J. Hood (LB) Out - Undisclosed. D. Johnson (RB) Out - Undisclosed. I. Stewart (WR) Out - Undisclosed. G. El-Hadi (OG) Questionable - Undisclosed. B. Norton (OG) Questionable - Undisclosed. A. Babalola (OG) Out - Knee.

USC Trojans:  M. Tagoa'i (LB) Questionable - Undisclosed. H. Dalton III (RB) Questionable - Undisclosed. A. Graham (CB) Questionable - Undisclosed. B. Jackson (RB) Questionable - Undisclosed. E. Paige (OG) Questionable - Undisclosed. P. Brown (CB) Questionable - Undisclosed. C. Johnson (CB) Out - Knee. C. Chittenden (K) Out - Undisclosed.

“I couldn’t be more proud of this young man. Everything you want, he does it the right way. He’s special.” - Sherrone Moore after his team’s win against Wisconsin in their last game. 

“We showed a lot of fight coming back to take the lead, but the reality is we squandered too many opportunities on both sides of the ball." - Lincoln Riley after his team’s loss against Illinois in their last game. 

WR McCulley, Donaven

WR Goodwin, Channing

WR Morgan, Semaj

TE Klein, Marlin

QB Underwood, Bryce

RB Haynes, Justice

WR Lane, Ja'Kobi

WR Hines, Tanook

WR Lemon, Makai

TE McRee, Lake

QB Maiava, Jayden

RB Jordan, Waymond

Passing: Bryce Underwood (1,003)

Rushing: Justice Haynes (654)

Receiving: Donaven McCulley (309)

Touchdowns: Justice Haynes (8)

Passing: Jayden Maiava (1,587)

Rushing: Waymond Jordan (537)

Receiving: Makai Lemon (589)

Touchdowns: Makai Lemon (6)

Coaches:

Michigan Wolverines: Sherrone Moore (2nd season)

USC Trojans: Lincoln Riley (4th season)