by Rod Pearson
Thursday, Sep 04, 2025
Game Time: 7:30 pm ET, Saturday, September 6, 2025
Venue: Gaylord Family - Oklahoma Memorial Stadium, Norman, OK
Where to Watch: ABC
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Michigan +4.5, Oklahoma -4.5; Over/Under: 44.5 points
Bet365: Point Spread: Michigan +5, Oklahoma -5; Over/Under: 45 points
BetMGM: Point Spread: Michigan +5.5, Oklahoma -5.5; Over/Under: 45.5 points
Season Record
Michigan Wolverines: 1-0 (0-0) (8th place, Big Ten)
Oklahoma Sooners: 1-0 (0-0) (10th place, SEC)
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Recent Form
Michigan Wolverines: won their last game at home against the New Mexico Lobos 34-17.
Oklahoma Sooners: won their last game at home against the Illinois State Redbirds 35-3.
Michigan Wolverines vs Oklahoma Sooners Preview and Analysis
Michigan is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against New Mexico 34-17. Bryce Underwood was the starting QB and he completed 21/31 passes for 251 passing yards, 1 touchdown, and 0 interceptions. Justice Haynes led the team in rushing yards with 159 and 3 TDs. Marlin Klein led the receivers with 93 receiving yards on 6 receptions and 1 TD. Ernest Hausmann led the defense in that game with 5 solo tackles and 3 assisted tackles while Cole Sullivan, Troy Bowles, and Dominic Nichols each led the defense in sacks with 1. Cole Sullivan, Brandyn Hillman, and TJ Guy each came away with 1 interception for them in that one.
Oklahoma is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Illinois State 35-3. John Mateer was the starting QB and he completed 30/37 passes for 392 passing yards, 3 touchdowns, and 1 interception. Tory Blaylock led the team in rushing yards with 44 and 1 TD. Keontez Lewis led the receivers with 119 receiving yards on 9 receptions and 2 TDs. Owen Heinecke led the defense in that game with 4 solo tackles and 0 assisted tackles while Sammy Omosigho and Taylor Wein each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Michigan vs Oklahoma Prediction
The current betting odds have Oklahoma listed as a 4.5 point favorite in this game according to Draftkings Sportsbook. Oklahoma is 1-0 overall and they are looking to have a big year after some disappointing seasons under Brent Venables. This is a make or break year for Venables and so far the team looked really good in their season opener. They weren't playing anyone special as they beat Illinois State 35-3, but Mateer looked great in the offense and the defense continues to be good under Venables. Meanwhile, Michigan is also 1-0 overall and had a tougher opponent in week 1 as they did play a team from the FBS, but New Mexico still isn't a great team. They beat New Mexico 34-17 and the offense looked good with their freshman QB, but the issues actually came on defense for them. They gave up 17 points at home and the defense didn't look nearly as good as it has looked in years past. That is going to be a big issue for them this season, especially against an SEC opponent that has a good defense and a really good defensive coach. Michigan will put up some points with that offense, but Oklahoma will be able to move the ball well at home against this weakened Michigan defense and that will be a key piece to them winning this game. The best way to place a bet here is on Oklahoma to cover the spread in this game.
Michigan Oklahoma Prediction: Our NCAAF Pick for Saturday, September 6, 2025 (7:30 pm ET start time) is Oklahoma 27 Michigan 20.
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NCAAF Betting Trends
Michigan Wolverines: 0-5 ATS in the first two weeks of the season. 3-7 ATS in non-conference games. 7-2 UNDER in non-conference games. 5-2 UNDER off a home win by 17 points or more.
Oklahoma Sooners: 9-5 ATS in home lined games. 8-3 ATS as a home favorite. 4-0 ATS in a home game where the total is between 42.5 and 49. 4-1 UNDER in the first two weeks of the season.
Key Injuries
Michigan Wolverines: H. Hansen (TE) Questionable - Undisclosed. I. Iwunnah (DL) Questionable - Undisclosed. C. Charleston (WR) Questionable - Undisclosed. D. Baxter (DL) Questionable - Undisclosed. J. Hood (LB) Questionable - Undisclosed. J. Volker (RB) Questionable - Undisclosed. D. Johnson (RB) Questionable - Undisclosed. B. Kuzdzal (RB) Questionable - Undisclosed. R. Moore (CB) Questionable - Undisclosed. D. Warren (QB) Questionable - Knee. C. Anderson (CB) Questionable - Undisclosed. M. Keene (QB) Questionable - Undisclosed. A. Babalola (OG) Out - Knee.
Oklahoma Sooners: G. Williams (CB) Questionable - Undisclosed. T. Tatum (RB) Questionable - Hamstring. E. Bowen (CB) Questionable - Leg. J. Gibson (WR) Questionable - Knee. J. Gibson (WR) Questionable - Leg. K. Daniels (WR) Questionable - Undisclosed.
Notable Quotes
“I couldn’t do that as a freshman. That was impressive.” - Sherrone Moore on Bryce Underwood after his team’s win against UNM in their last game.
“Oh, it’s awesome. It’s a blessing. You go in the record books in Game 1 — it’s a super good feeling.” - John Mateer after their win against Illinois State in their last game.
Starting Lineups
Michigan Wolverines
WR McCulley, Donaven
WR Moore, Fredrick
WR Morgan, Semaj
TE Klein, Marlin
QB Underwood, Bryce
RB Haynes, Justice
FB Bredeson, Max
Oklahoma Sooners
WR Lewis, Keontez
WR Burks, Deion
WR Sategna III, Isaiah
TE Kanak, Jaren
QB Mateer, John
RB Barnes, Jovantae
Statistical Leaders
Michigan Wolverines
Passing: B. Underwood (251)
Rushing: J. Haynes (159)
Receiving: M. Klein (93)
Touchdowns: J. Haynes (3)
Oklahoma Sooners
Passing: J. Mateer (392)
Rushing: T. Blaylock (44)
Receiving: K. Lewis (119)
Touchdowns: K. Lewis (2)
Coaches:
Michigan Wolverines: Sherrone Moore (2nd season)
Oklahoma Sooners: Brent Venables (4th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
