Michigan Wolverines vs Northwestern Wildcats Prediction, Picks and Game Preview - 11/15/2025

Game Time: 12:00 pm ET, Saturday, November 15, 2025

Venue:  Wrigley Field, Chicago, IL

Where to Watch:  FOX

DraftKings:  Point Spread:  Michigan -11.5, Northwestern +11.5; Over/Under:  40.5 points

Bet365:  Point Spread:  Michigan -11.5, Northwestern +11.5; Over/Under:  41 points

BetMGM:  Point Spread:  Michigan -10.5, Northwestern +10.5; Over/Under:  41.5 points

Michigan Wolverines:  7-2 (5-1) (5th place, Big Ten)

Northwestern Wildcats:  5-4 (3-3) (11th place, Big Ten)

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Michigan Wolverines:  won their last game at home against the Purdue Boilermakers 21-16.

Northwestern Wildcats:  lost their last game on the road against the USC Trojans 38-17.

Michigan is entering this game with a 7-2 record overall and they have a 5-1 record in their conference games too. They are 5-0 in their home games, 2-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at a neutral site for this game. They won their last game against Purdue 21-16. Bryce Underwood was the starting QB and he completed 13/22 passes for 145 passing yards, 0 touchdowns, and 1 interception. Jordan Marshall led the team in rushing yards with 185 and 3 TDs. Zack Marshall led the receivers with 58 receiving yards on 3 receptions. Ernest Hausmann led the defense in that game with 8 solo tackles and 3 assisted tackles while Derrick Moore led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.

 

 

 

Northwestern is entering this game with a 5-4 record overall and they have a 3-3 record in their conference games too. They are 4-1 in their home games, 1-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at a neutral site for this game. They lost their last game against USC 38-17. Preston Stone was the starting QB and he completed 20/30 passes for 150 passing yards, 1 touchdown, and 0 interceptions. Caleb Komolafe led the team in rushing yards with 118 and 1 TD. Caleb Komolafe led the receivers with 40 receiving yards on 5 receptions. Mac Uihlein led the defense in that game with 8 solo tackles and 3 assisted tackles while Najee Story led the defense in sacks with 1. Najee Story came away with the only interception for them in that one.

The current betting odds have Northwestern listed as an 11.5 point underdog in this game according to Draftkings Sportsbook. Northwestern has looked good in their games this season with their 5-4 record overall, but their 3-3 conference record has them right in the middle of the Big Ten. This game is at a neutral site, but it is still going to be more of a home advantage for Northwestern and they have looked a lot better in their home games this year. Meanwhile, Michigan has looked really good in their games this season with their 7-2 record overall and their 5-1 conference record which has them right near the top of the Big Ten. They are currently ranked inside the top 25 and still have a shot at the playoffs with that game against Ohio State at the end of the season still looming. They haven't been a great road team this year though with their 2-2 road record. They are also off a 21-16 win over Purdue in their last one and their defense has looked a lot better lately, but they still haven't been blowing many teams out in their wins. They have a more run heavy style that isn't going to allow them to pull away from Northwestern on the road, and Bryce Underwood hasn't looked as good in their road games either. Michigan has the talent to win this game, but they aren't going to be blowing any teams out in their wins so Northwestern can keep this a closer game since they have looked a lot better at home all year. The best way to place a bet here is on Northwestern to cover the spread in this game. 

Michigan Northwestern Prediction:  Our NCAAF Pick for Saturday, November 15, 2025 (12:00 pm ET start time) is Michigan 24 Northwestern 17.

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Michigan Wolverines: 4-1 ATS as a favorite of 3.5 to 10 points. 12-5 ATS when playing against a team with a winning record. 6-3 ATS versus good rushing teams - averaging 4.75 rushing yards/carry or more. 16-5 OVER as a neutral field favorite. 24-11 OVER in games played on a neutral field.

Northwestern Wildcats: 4-7 ATS as a neutral field underdog of 7.5 to 14 points. 18-25 ATS after a 2 game road trip. 9-3 OVER off a loss against a conference rival. 9-2 OVER after a loss by 17 or more points. 5-1 OVER versus good rushing teams - averaging 200  rushing yards/game or more.

Michigan Wolverines:  J. Haynes (RB) Out - Foot. J. Rolder (LB) Questionable - Undisclosed. C. Sullivan (LB) Questionable - Undisclosed. E. Link (OG) Questionable - Undisclosed. R. Moore (CB) Questionable - Undisclosed. M. Ka'apana (RB) Questionable - Undisclosed. H. Hansen (TE) Questionable - Undisclosed. C. Charleston (WR) Out - Undisclosed. D. Baxter (DL) Out - Undisclosed. J. Hood (LB) Out - Undisclosed. D. Johnson (RB) Out - Undisclosed. I. Stewart (WR) Out - Undisclosed. A. Babalola (OG) Out - Knee.

Northwestern Wildcats:  C. Petrucci (TE) Questionable - Undisclosed. J. Borcherding (OG) Questionable - Undisclosed. E. Smith (CB) Questionable - Undisclosed. T. Jumpp (DL) Questionable - Undisclosed. T. Crane (WR) Questionable - Undisclosed. S. Valeri (CB) Questionable - Undisclosed. R. Hagarty (DL) Questionable - Undisclosed. D. Walters (CB) Questionable - Undisclosed. C. Shivers (CB) Questionable - Undisclosed. J. Reynolds II (LB) Questionable - Undisclosed. B. Blueitt (WR) Questionable - Undisclosed. C. Russell (WR) Questionable - Undisclosed. D. Reeder (RB) Questionable - Undisclosed. J. Himon II (RB) Questionable - Undisclosed. J. Lewis (CB) Out - Undisclosed. Y. Karlaftis (LB) Out - Undisclosed. D. Roberts (DL) Out - Undisclosed. C. Porter (RB) Out - Lower Body.

“We’re in a position to do everything we wanted to accomplish.” - Sherrone Moore after his team’s win against Purdue in their last game. 

“I mean, we knew Nebraska was an outlier in their passing game. Nebraska had done a great job against USC, but you knew USC was going to find a way to respond. They’re talented. Talented wide receivers. Quarterback plays at a very high level. Coach Riley is a great coach. And ultimately, we ended up playing on our heels most of the night.” - David Braun after his team’s loss against USC in their last game. 

WR McCulley, Donaven

WR Goodwin, Channing

WR Morgan, Semaj

TE Klein, Marlin

QB Underwood, Bryce

RB Haynes, Justice

WR Eligon II, Hayden

WR Wilde, Griffin

WR Wagner, Drew

TE Albright, Lawson

QB Stone, Preston

RB Komolafe, Caleb

Passing: Bryce Underwood (1,671)

Rushing: Justice Haynes (857)

Receiving: Donaven McCulley (383)

Touchdowns: Justice Haynes (10)

Passing: Preston Stone (1,522)

Rushing: Caleb Komolafe (726)

Receiving: Griffin Wilde (593)

Touchdowns: Caleb Komolafe (8)

Coaches:

Michigan Wolverines: Sherrone Moore (2nd season)

Northwestern Wildcats: David Braun (3rd season)