Michigan Wolverines vs Michigan State Spartans Prediction, Picks and Game Preview - 10/25/2025

Game Time: 7:30 pm ET, Saturday, October 25, 2025

Venue:  Spartan Stadium, East Lansing, MI 

Where to Watch:  NBC

DraftKings:  Point Spread:  Michigan -14.5, MSU +14.5; Over/Under:  48.5 points

Bet365:  Point Spread:  Michigan -14.5, MSU +14.5; Over/Under:  48.5 points

BetMGM:  Point Spread:  Michigan -14.5, MSU +14.5; Over/Under:  48.5 points

Michigan Wolverines:  5-2 (3-1) (6th place, Big Ten)

Michigan State Spartans:  3-4 (0-4) (16th place, Big Ten)

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Michigan Wolverines:  won their last game at home against the Washington Huskies 24-7.

Michigan State Spartans:  lost their last game on the road against the Indiana Hoosiers 38-13.

Michigan is entering this game with a 5-2 record overall and they have a 3-1 record in their conference games too. They are 4-0 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Washington 24-7. Bryce Underwood was the starting QB and he completed 21/27 passes for 230 passing yards, 2 touchdowns, and 0 interceptions. Jordan Marshall led the team in rushing yards with 133 and 1 TD. Zack Marshall led the receivers with 72 receiving yards on 5 receptions and 1 TD. Zeke Berry led the defense in that game with 6 solo tackles and 0 assisted tackles while Derrick Moore led the defense in sacks with 2. Jimmy Rolder, Jacob Oden, and Cole Sullivan each came away with 1 interception for them in that one.

 

 

 

Michigan State is entering this game with a 3-4 record overall and they have a 0-4 record in their conference games too. They are 3-1 in their home games, 0-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Indiana 38-13. Aidan Chiles was the starting QB and he completed 27/33 passes for 243 passing yards, 1 touchdown, and 0 interceptions. Aidan Chiles led the team in rushing yards with 48. Nick Marsh led the receivers with 64 receiving yards on 7 receptions and 1 TD. Malcolm Bell led the defense in that game with 7 solo tackles and 0 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

The current betting odds have Michigan listed as a 14.5 point favorite in this game according to Draftkings Sportsbook. Michigan has looked really good in their games this season with their 5-2 record overall and their 3-1 conference record which has them right near the top of the Big Ten. They already have 2 losses this season so they need to run the table to make the playoffs, but everything is still in front of them with only 1 conference loss so they are going to be motivated to keep rolling. They looked great in their last one with a 24-7 win over Washington and they have looked a lot better this year against weaker opponents in games where they can play with a lead, and that is something they will be able to do here. Meanwhile, Michigan State hasn't looked good in their games this season with their 3-4 record overall and their 0-4 conference record which has them right near the bottom of the Big Ten. They have looked a lot better on their home field this year with their 3-1 home record, but all of those wins were in non-conference games. They haven't looked good at all in any of their games against stronger opponents and they are off a 38-13 loss to Indiana in their last one too. Michigan has looked a lot better lately as Bryce Underwood gets better every game in this offense, and this isn't going to be a far travel for them either. Look for Michigan to keep rolling here against one of the worst teams in the Big Ten this year. The best way to place a bet here is on Michigan to cover the spread in this game. 

Michigan Michigan State Prediction:  Our NCAAF Pick for Saturday, October 25, 2025 (7:30 pm ET start time) is Michigan 35 Michigan State 13.

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Michigan Wolverines: 14-8 ATS against conference opponents. 9-5 ATS after allowing 14 points or less last game. 5-2 ATS after a game with a turnover margin of +2 or better. 5-2 OVER as a favorite of 10.5 to 21 points. 

Michigan State Spartans: 10-16 ATS in all lined games. 3-11 ATS in home lined games. 4-11 ATS in games played on a grass field. 9-5 OVER off a loss against a conference rival. 6-1 OVER when playing against a good team (Win Pct. 60% to 75%).

Michigan Wolverines:  M. Ka'apana (RB) Questionable - Undisclosed. M. Klein (TE) Questionable - Undisclosed. D. Warren (QB) Questionable - Knee. C. Charleston (WR) Out - Undisclosed. J. Haynes (RB) Questionable - Undisclosed. D. Baxter (DL) Out - Undisclosed. J. Hood (LB) Out - Undisclosed. D. Johnson (RB) Out - Undisclosed. I. Stewart (WR) Out - Undisclosed. B. Norton (OG) Questionable - Undisclosed. A. Babalola (OG) Out - Knee.

Michigan State Spartans:  G. Kelly (DL) Questionable - Undisclosed. S. Ramil (OG) Questionable - Undisclosed. T. Ahmetbasic (K) Questionable - Undisclosed. J. Savoury (TE) Questionable - Undisclosed. M. Pulliam (LB) Questionable - Undisclosed. B. Parachek (TE) Questionable - Undisclosed. K. Phillips (OG) Questionable - Undisclosed. A. Willie (CB) Questionable - Undisclosed. A. Brown (WR) Questionable - Undisclosed. A. Lepo (OG) Out - Undisclosed. K. Schickel (LS) Out - Undisclosed. A. Lafaele (DL) Out - Undisclosed. N. Martinez (CB) Questionable - Undisclosed. L. Vincic (OG) Out - Undisclosed. B. Pretzlaff (LB) Out - Undisclosed. A. Brinson IV (CB) Out - Undisclosed. C. Gash (CB) Out - Undisclosed.

“It felt like Michigan football and what it should feel like.” - Sherrone Moore after his team’s win against Washington in their last game. 

"The margin for error against a team like that, we were not able to make that up. In the second half, we've got to find a way to get a couple of stops." - Jonathan Smith after his team’s loss against Indiana in their last game. 

WR McCulley, Donaven

WR Goodwin, Channing

WR Morgan, Semaj

TE Klein, Marlin

QB Underwood, Bryce

RB Haynes, Justice

WR Marsh, Nick

WR Kelly, Omari

WR McCray, Chrishon

TE Velling, Jack

QB Chiles, Aidan

RB Frazier, Makhi

FB Coyne, Jay

Passing: Bryce Underwood (1,440)

Rushing: Justice Haynes (705)

Receiving: Donaven McCulley (369)

Touchdowns: Justice Haynes (8)

Passing: Aidan Chiles (1,262)

Rushing: Makhi Frazier (384)

Receiving: Omari Kelly (406)

Touchdowns: Aidan Chiles (5)

Coaches:

Michigan Wolverines: Sherrone Moore (2nd season)

Michigan State Spartans: Jonathan Smith (2nd season)