Miami Marlins vs Houston Astros Prediction, Preview and Odds - 07/22/2026

Game Time: 8:10 pm ET, Wednesday, July 22, 2026

Venue:  Daikin Park, Houston, TX

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Marlins +100, Astros -120; Over/Under:  8 runs

Bet365:  Moneyline odds:  Marlins +100, Astros -120; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Marlins +100, Astros -120; Over/Under:  8 runs

Miami Marlins:  52-49 (3rd place, NL East)

Houston Astros:  48-54 (3rd place, AL West)

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Miami Marlins:  3-7 last 10

Houston Astros:  3-7 last 10

The Marlins are entering this series off a loss and got swept in their 3-game series against the Milwaukee Brewers 3-0 in their last series. They enter this game with a 52-49 record overall and have a road record of 21-29. This is the series finale of a 3-game series with the Astros on Wednesday with the 2nd game still to be played on Tuesday. The Marlins lost the series opener on Monday. Their offense ranks 7th in the MLB with a .736 OPS. Tyler Phillips is their starting pitcher on Tuesday while Sandy Alcantara is making his start in this game on Wednesday. He is 10-5 with a 3.89 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 1 HR, and 4 BB with 7 SO on 3 hits through 6 IP against the Milwaukee Brewers.

The Astros are entering this series off a loss and got swept in their 3-game series against the Baltimore Orioles 3-0 in their last series. They enter this game with a 48-54 record overall and have a home record of 24-27. This is the 3rd game of a 3-game series with the Marlins on Wednesday with the 2nd game of this series still to be played on Tuesday. The Astros won the 1st game of this series on Monday. Their offense ranks 14th in the MLB with a .726 OPS. Rookie pitcher Tatsuya Imai is their starting pitcher on Tuesday while Peter Lambert is making his start in this game on Wednesday. He is 8-5 with a 3.03 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 3 walks with 10 strikeouts on 3 hits through 6 innings pitched against the Baltimore Orioles.

The current betting odds have the Astros listed as a slight favorite in this game according to Draftkings Sportsbook. The Marlins have looked good in their games this season with their 52-49 record overall which has them right in the middle of the NL East. They haven't been a good road team though with their 21-29 road record this year. Meanwhile, the Astros haven't looked good in their games this season with their 48-54 record overall which has them right in the middle of the AL West. They haven't looked great in their own ballpark either with their 24-27 home record this season. The Marlins were rolling into the All-Star break, but they have looked terrible coming out of it. They are 3-7 in their last 10 games now and their offense hasn't looked good either. The Astros haven't looked any better lately as they are also 3-7 in their last 10 games, but they took the 1st game of this series and will be looking to get themselves back in the race for the AL West, not too far out of it. The Astros are going with Lambert in this one and he has looked good this season. He is 8-5 with a 3.03 ERA and he hasn't been giving up many runs lately. He is coming off another great start in which he gave up 1 earned run which has been a common theme for him, and the team has won 2 of their last 3 games with him starting too. The Marlins are going with Alcantara in this one and he has looked good this season too. He is 10-5 with a 3.89 ERA, but he has also been really up and down all season and lately the team has been having trouble with him. He only gave up 1 earned run in his last start, but the team has lost 2 games in a row now with him starting and the bullpen hasn't looked that great either. Look for the Astros to take advantage of the Marlins in this big slump. The best way to place a bet here is on the Astros to win this game. 

Marlins Astros Prediction:  Our MLB Pick for Wednesday, July 22, 2026 (8:10 pm ET start time) is Astros 3 Marlins 2.

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Miami Marlins: 20-19 (+4.9 units) on the moneyline against AL West opponents. 193-232 (+16.4 units) on the moneyline in all games. 94-118 (+24 units) on the moneyline in road games. 23-11 OVER as a road underdog of +100 or higher.

Houston Astros: 224-202 (-9.3 units) on the moneyline in all games. 116-98 (-12.3 units) on the moneyline in home games. 130-114 (-33.2 units) on the moneyline as a favorite of -110 or higher. 25-12 OVER when playing against a team with a winning record.

Miami Marlins:  O. Lopez (SS) Day To Day - Hand. M. Meyer (SP) Fifteen Day IL - Neck. W. Kempner (RP) Fifteen Day IL - Elbow. J. King (RP) Fifteen Day IL - Ankle. O. Caissie (RF) Ten Day IL - Calf. A. Bender (RP) Fifteen Day IL - Shin. J. Ekness (RP) Sixty Day IL - Calf. A. Nardi (RP) Sixty Day IL - Ribs. R. Snelling (SP) Sixty Day IL - Elbow. A. Mazur (SP) Sixty Day IL - Elbow. R. Henriquez (RP) Sixty Day IL - Elbow.

Houston Astros:  C. Walker (1B) Day To Day - Hip. B. Matthews (CF) Ten Day IL - Knee. M. Burrows (SP) Fifteen Day IL - Elbow. C. Correa (SS) Sixty Day IL - Ankle. H. Wesneski (RP) Sixty Day IL - Elbow. B. Walter (RP) Sixty Day IL - Elbow. 

“I think we are going to see how these next three days go here. We had Brzykcy come up to give us another arm in the bullpen here. We will just reassess and decide what we think we want to do, what’s best when that spot comes up.” - Clayton McCullough after his team’s loss against the Astros in their game on Monday.

“Just locked in. What he’s doing right now, he’s in a different league.” - Joe Espada on Yordan Alvarez after his team’s win against the Marlins in their game on Monday. 

Kyle Stowers (L) 1B

Heriberto Hernández (R) LF

Xavier Edwards (S) 2B

Liam Hicks (L) DH

Griffin Conine (L) RF

Jakob Marsee (L) CF

Joe Mack (L) C

Graham Pauley (L) 3B

Javier Sanoja (R) SS

Jeremy Peña (R) SS

Yordan Alvarez (L) DH

Isaac Paredes (R) 3B

Jose Altuve (R) 2B

LaMonte Wade Jr. (L) 1B

Yainer Diaz (R) C

Taylor Trammell (L) RF

Zach Dezenzo (R) LF

Lucas Spence (L) CF

Batting Average:  Otto Lopez (.335)

Hits:  Otto Lopez (130)

Home Runs:  Liam Hicks (14)

RBI:  Liam Hicks (60)

Stolen Bases:  Esteury Ruiz (20)

Wins:  Sandy Alcantara (10)

Saves:  Pete Fairbanks (13)

ERA:  Josh Ekness (1.69)

Batting Average:  Yordan Alvarez (.324)

Hits:  Yordan Alvarez (118)

Home Runs:  Yordan Alvarez (33)

RBI:  Yordan Alvarez (75)

Stolen Bases:  Cam Smith (10)

Wins:  Peter Lambert (8)

Saves:  Josh Hader (10)

ERA:  Miguel Ullola (0.00)

Managers:

Miami Marlins: Clayton McCullough (2nd season)

Houston Astros: Joe Espada (3rd season)